{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:3JNSBZWTZOVKIIE3WOZ7FI2JFE","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"99a55ed32ebc6dd2e6317b8b07e41cf684c33220927588214731d0866f3683db","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2016-09-22T14:40:33Z","title_canon_sha256":"8fef02eb133703c722a9148e13716f1fd4925cccf5e6fca636f386013c5fff9c"},"schema_version":"1.0","source":{"id":"1609.07000","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1609.07000","created_at":"2026-05-18T01:04:04Z"},{"alias_kind":"arxiv_version","alias_value":"1609.07000v1","created_at":"2026-05-18T01:04:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1609.07000","created_at":"2026-05-18T01:04:04Z"},{"alias_kind":"pith_short_12","alias_value":"3JNSBZWTZOVK","created_at":"2026-05-18T12:29:55Z"},{"alias_kind":"pith_short_16","alias_value":"3JNSBZWTZOVKIIE3","created_at":"2026-05-18T12:29:55Z"},{"alias_kind":"pith_short_8","alias_value":"3JNSBZWT","created_at":"2026-05-18T12:29:55Z"}],"graph_snapshots":[{"event_id":"sha256:aa34dd9cd6879a6f2a1edb72df0c2e557364e4936543ac4882b9fe1f8fb2edb8","target":"graph","created_at":"2026-05-18T01:04:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Cellulosomes are complex multi-enzyme machineries which efficiently degrade plant cell-wall polysaccharides. The multiple domains of the cellulosome proteins are often tethered together by intrinsically disordered regions. The properties and functions of these disordered linkers are not well understood. In this work, we study endoglucanase Cel8A, which is a relevant enzymatic component of the cellulosomes of Clostridium thermocellum. We use both all-atom and coarse-grained simulations to investigate how the equilibrium conformations of the catalytic domain of Cel8A are affected by the disorder","authors_text":"Bartosz Rozycki, Marek Cieplak","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2016-09-22T14:40:33Z","title":"Stiffness of the C-terminal disordered linker affects the geometry of the active site in endoglucanase Cel8A"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1609.07000","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:724382e808d9e0f4ce7ccddd79b518432491d5c1c3dc42f5c0db3eeadabee5c7","target":"record","created_at":"2026-05-18T01:04:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"99a55ed32ebc6dd2e6317b8b07e41cf684c33220927588214731d0866f3683db","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2016-09-22T14:40:33Z","title_canon_sha256":"8fef02eb133703c722a9148e13716f1fd4925cccf5e6fca636f386013c5fff9c"},"schema_version":"1.0","source":{"id":"1609.07000","kind":"arxiv","version":1}},"canonical_sha256":"da5b20e6d3cbaaa4209bb3b3f2a349290794a5f98eb9cdb5d0700c6aaa4b163f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"da5b20e6d3cbaaa4209bb3b3f2a349290794a5f98eb9cdb5d0700c6aaa4b163f","first_computed_at":"2026-05-18T01:04:04.664771Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:04:04.664771Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"XXwPx735g9HTRc0Nup+lvcfwzwL8RPWgYo+a4DVcMdrDpKRi9FoCnobortGxkXbsIwhkCvNuDQVcFYeBSwr1BQ==","signature_status":"signed_v1","signed_at":"2026-05-18T01:04:04.665326Z","signed_message":"canonical_sha256_bytes"},"source_id":"1609.07000","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:724382e808d9e0f4ce7ccddd79b518432491d5c1c3dc42f5c0db3eeadabee5c7","sha256:aa34dd9cd6879a6f2a1edb72df0c2e557364e4936543ac4882b9fe1f8fb2edb8"],"state_sha256":"aeb05601c029df20da55980bc0f02837ae1b89fa746aa78ee3868089d9e1d839"}