{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:3P5L5Y2IWDZVSHMBUOKV3BDM5Y","short_pith_number":"pith:3P5L5Y2I","canonical_record":{"source":{"id":"1904.01116","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2019-04-01T21:29:41Z","cross_cats_sorted":[],"title_canon_sha256":"1aa69855671867a01b3d9b171c08e8a64382eb91d2f8e65835a203cdff4875f3","abstract_canon_sha256":"fbada2d14ed5e36fc81d01665225ff30d90f078afa2bdac735724bac47cb55c2"},"schema_version":"1.0"},"canonical_sha256":"dbfabee348b0f3591d81a3955d846cee0a75ef2aeea0b3d0bde8d0e3570c4bb4","source":{"kind":"arxiv","id":"1904.01116","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1904.01116","created_at":"2026-05-17T23:49:35Z"},{"alias_kind":"arxiv_version","alias_value":"1904.01116v1","created_at":"2026-05-17T23:49:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1904.01116","created_at":"2026-05-17T23:49:35Z"},{"alias_kind":"pith_short_12","alias_value":"3P5L5Y2IWDZV","created_at":"2026-05-18T12:33:07Z"},{"alias_kind":"pith_short_16","alias_value":"3P5L5Y2IWDZVSHMB","created_at":"2026-05-18T12:33:07Z"},{"alias_kind":"pith_short_8","alias_value":"3P5L5Y2I","created_at":"2026-05-18T12:33:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:3P5L5Y2IWDZVSHMBUOKV3BDM5Y","target":"record","payload":{"canonical_record":{"source":{"id":"1904.01116","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2019-04-01T21:29:41Z","cross_cats_sorted":[],"title_canon_sha256":"1aa69855671867a01b3d9b171c08e8a64382eb91d2f8e65835a203cdff4875f3","abstract_canon_sha256":"fbada2d14ed5e36fc81d01665225ff30d90f078afa2bdac735724bac47cb55c2"},"schema_version":"1.0"},"canonical_sha256":"dbfabee348b0f3591d81a3955d846cee0a75ef2aeea0b3d0bde8d0e3570c4bb4","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:49:35.894640Z","signature_b64":"9pZHBwo0sIeAgKpkqKRRLYMpXIu7fjw8kZHeMrh/wSqkhpK3NH93ubsavwmsms/rQvY9lxP2D2QvNuVnMBWKDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"dbfabee348b0f3591d81a3955d846cee0a75ef2aeea0b3d0bde8d0e3570c4bb4","last_reissued_at":"2026-05-17T23:49:35.893924Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:49:35.893924Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1904.01116","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:49:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"gDhaWKCDlyFuA486su4zGZlcrA25DQ8tfWhte9ZvNllfYHvQkr5A0XcBiZNR3hfWAj1cOMzzluLTZx9gmxyRAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T06:10:02.891828Z"},"content_sha256":"6d726ad627ff04776c0c15e85ef17934e76359417fcc04735ef7b0ed0fd6643f","schema_version":"1.0","event_id":"sha256:6d726ad627ff04776c0c15e85ef17934e76359417fcc04735ef7b0ed0fd6643f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:3P5L5Y2IWDZVSHMBUOKV3BDM5Y","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Gene-based Association Analysis for Bivariate Time-to-event Data through Functional Regression with Copula Models","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.AP","authors_text":"Wei Chen, Yi Liu, Ying Ding, Yue Wei","submitted_at":"2019-04-01T21:29:41Z","abstract_excerpt":"Several gene-based association tests for time-to-event traits have been proposed recently, to detect whether a gene region (containing multiple variants), as a set, is associated with the survival outcome. However, for bivariate survival outcomes, to the best of our knowledge, there is no statistical method that can be directly applied for gene-based association analysis. Motivated by a genetic study to discover gene regions associated with the progression of a bilateral eye disease, Age-related Macular Degeneration (AMD), we implement a novel functional regression method under the copula fram"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1904.01116","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:49:35Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"qCBQqklD88+DlDd3uj0AFYT+EL73muw9ETLUfdpinkU4mk8BQWVjfjCv1Ca7e1ufQ3wGRYrYZam+qLYvegrqBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T06:10:02.892504Z"},"content_sha256":"e1bdc96cbb8fc0e97eac9a41517613233ce14f9b5a7e5b7585e98b11416b84b0","schema_version":"1.0","event_id":"sha256:e1bdc96cbb8fc0e97eac9a41517613233ce14f9b5a7e5b7585e98b11416b84b0"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/3P5L5Y2IWDZVSHMBUOKV3BDM5Y/bundle.json","state_url":"https://pith.science/pith/3P5L5Y2IWDZVSHMBUOKV3BDM5Y/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/3P5L5Y2IWDZVSHMBUOKV3BDM5Y/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T06:10:02Z","links":{"resolver":"https://pith.science/pith/3P5L5Y2IWDZVSHMBUOKV3BDM5Y","bundle":"https://pith.science/pith/3P5L5Y2IWDZVSHMBUOKV3BDM5Y/bundle.json","state":"https://pith.science/pith/3P5L5Y2IWDZVSHMBUOKV3BDM5Y/state.json","well_known_bundle":"https://pith.science/.well-known/pith/3P5L5Y2IWDZVSHMBUOKV3BDM5Y/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:3P5L5Y2IWDZVSHMBUOKV3BDM5Y","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fbada2d14ed5e36fc81d01665225ff30d90f078afa2bdac735724bac47cb55c2","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2019-04-01T21:29:41Z","title_canon_sha256":"1aa69855671867a01b3d9b171c08e8a64382eb91d2f8e65835a203cdff4875f3"},"schema_version":"1.0","source":{"id":"1904.01116","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1904.01116","created_at":"2026-05-17T23:49:35Z"},{"alias_kind":"arxiv_version","alias_value":"1904.01116v1","created_at":"2026-05-17T23:49:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1904.01116","created_at":"2026-05-17T23:49:35Z"},{"alias_kind":"pith_short_12","alias_value":"3P5L5Y2IWDZV","created_at":"2026-05-18T12:33:07Z"},{"alias_kind":"pith_short_16","alias_value":"3P5L5Y2IWDZVSHMB","created_at":"2026-05-18T12:33:07Z"},{"alias_kind":"pith_short_8","alias_value":"3P5L5Y2I","created_at":"2026-05-18T12:33:07Z"}],"graph_snapshots":[{"event_id":"sha256:e1bdc96cbb8fc0e97eac9a41517613233ce14f9b5a7e5b7585e98b11416b84b0","target":"graph","created_at":"2026-05-17T23:49:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Several gene-based association tests for time-to-event traits have been proposed recently, to detect whether a gene region (containing multiple variants), as a set, is associated with the survival outcome. However, for bivariate survival outcomes, to the best of our knowledge, there is no statistical method that can be directly applied for gene-based association analysis. Motivated by a genetic study to discover gene regions associated with the progression of a bilateral eye disease, Age-related Macular Degeneration (AMD), we implement a novel functional regression method under the copula fram","authors_text":"Wei Chen, Yi Liu, Ying Ding, Yue Wei","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2019-04-01T21:29:41Z","title":"Gene-based Association Analysis for Bivariate Time-to-event Data through Functional Regression with Copula Models"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1904.01116","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6d726ad627ff04776c0c15e85ef17934e76359417fcc04735ef7b0ed0fd6643f","target":"record","created_at":"2026-05-17T23:49:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fbada2d14ed5e36fc81d01665225ff30d90f078afa2bdac735724bac47cb55c2","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2019-04-01T21:29:41Z","title_canon_sha256":"1aa69855671867a01b3d9b171c08e8a64382eb91d2f8e65835a203cdff4875f3"},"schema_version":"1.0","source":{"id":"1904.01116","kind":"arxiv","version":1}},"canonical_sha256":"dbfabee348b0f3591d81a3955d846cee0a75ef2aeea0b3d0bde8d0e3570c4bb4","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"dbfabee348b0f3591d81a3955d846cee0a75ef2aeea0b3d0bde8d0e3570c4bb4","first_computed_at":"2026-05-17T23:49:35.893924Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:49:35.893924Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"9pZHBwo0sIeAgKpkqKRRLYMpXIu7fjw8kZHeMrh/wSqkhpK3NH93ubsavwmsms/rQvY9lxP2D2QvNuVnMBWKDQ==","signature_status":"signed_v1","signed_at":"2026-05-17T23:49:35.894640Z","signed_message":"canonical_sha256_bytes"},"source_id":"1904.01116","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6d726ad627ff04776c0c15e85ef17934e76359417fcc04735ef7b0ed0fd6643f","sha256:e1bdc96cbb8fc0e97eac9a41517613233ce14f9b5a7e5b7585e98b11416b84b0"],"state_sha256":"eb60b8cb6225420350a03021be0767bec6833afa338fdd5508dee1508357eb7e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Z2viOMhqk3GXZHhyT6t33fKnWKRVVKYZcMb8Y/i9LDcz9PxPIIfjhuwomZ38ZQg6BdD2n75tShnmA6396F1tAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T06:10:02.895983Z","bundle_sha256":"a492de37c30ad1d95cde8561a03c5ea485ae8b60fbaff314cb71083e31f0ff5a"}}