{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:3RW4RR3NNNBMRLTFLDECUQHLMR","short_pith_number":"pith:3RW4RR3N","canonical_record":{"source":{"id":"1810.02285","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2018-10-04T16:00:53Z","cross_cats_sorted":[],"title_canon_sha256":"cadba14ab8f4307820e75a498a5850b347d2215bc65627662164430aad098b59","abstract_canon_sha256":"8d10670f98c0f8f5a51bfe98370005171071d865b459e1bd2e5f7f57bc4dd663"},"schema_version":"1.0"},"canonical_sha256":"dc6dc8c76d6b42c8ae6558c82a40eb647273d1fe2a71ed4e1eb9c7c89a290349","source":{"kind":"arxiv","id":"1810.02285","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1810.02285","created_at":"2026-05-17T23:52:52Z"},{"alias_kind":"arxiv_version","alias_value":"1810.02285v2","created_at":"2026-05-17T23:52:52Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1810.02285","created_at":"2026-05-17T23:52:52Z"},{"alias_kind":"pith_short_12","alias_value":"3RW4RR3NNNBM","created_at":"2026-05-18T12:32:02Z"},{"alias_kind":"pith_short_16","alias_value":"3RW4RR3NNNBMRLTF","created_at":"2026-05-18T12:32:02Z"},{"alias_kind":"pith_short_8","alias_value":"3RW4RR3N","created_at":"2026-05-18T12:32:02Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:3RW4RR3NNNBMRLTFLDECUQHLMR","target":"record","payload":{"canonical_record":{"source":{"id":"1810.02285","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2018-10-04T16:00:53Z","cross_cats_sorted":[],"title_canon_sha256":"cadba14ab8f4307820e75a498a5850b347d2215bc65627662164430aad098b59","abstract_canon_sha256":"8d10670f98c0f8f5a51bfe98370005171071d865b459e1bd2e5f7f57bc4dd663"},"schema_version":"1.0"},"canonical_sha256":"dc6dc8c76d6b42c8ae6558c82a40eb647273d1fe2a71ed4e1eb9c7c89a290349","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:52:52.006139Z","signature_b64":"lVH+dVGS7vBNCeQ80DSTbXqp84wuBSWrxXR5uFigPc0K3RDUfUggJXZny5xT6U5B2byW45OgrMjIkIkPiX8LBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"dc6dc8c76d6b42c8ae6558c82a40eb647273d1fe2a71ed4e1eb9c7c89a290349","last_reissued_at":"2026-05-17T23:52:52.005200Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:52:52.005200Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1810.02285","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:52:52Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9nNa01K7TQmFIqE1GgoYY7iA1CBenV+6JVyo3o9PiGRQxh9ONlWOS30Hb7Zriq6e9rDIV0l6iCGCS3Pm4ZJIAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T10:02:51.089941Z"},"content_sha256":"bfcdf9d960c3330d01f6f4d01599a450869876cd222847676b0a843adfa52db5","schema_version":"1.0","event_id":"sha256:bfcdf9d960c3330d01f6f4d01599a450869876cd222847676b0a843adfa52db5"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:3RW4RR3NNNBMRLTFLDECUQHLMR","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"ASIED: A Bayesian Adaptive Subgroup-Identification Enrichment Design","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.AP","authors_text":"Florica Constantine, Yanxun Xu, Yili L. Pritchett, Yuan Yuan","submitted_at":"2018-10-04T16:00:53Z","abstract_excerpt":"Developing targeted therapies based on patients' baseline characteristics and genomic profiles such as biomarkers has gained growing interests in recent years. Depending on patients' clinical characteristics, the expression of specific biomarkers or their combinations, different patient subgroups could respond differently to the same treatment. An ideal design, especially at the proof of concept stage, should search for such subgroups and make dynamic adaptation as the trial goes on. When no prior knowledge is available on whether the treatment works on the all-comer population or only works o"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1810.02285","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:52:52Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"rY4smd39ydSwITIjxpNMy43YTpMWIPOve8jT9kcvXM6+Zlo262jAD8NbgfFyzoh6opX5ecN/5gl622u+PanACQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T10:02:51.090521Z"},"content_sha256":"4dd42689d682fd2325433f1a482aee5eb349df7a7255bcb1df310c2b73b4522b","schema_version":"1.0","event_id":"sha256:4dd42689d682fd2325433f1a482aee5eb349df7a7255bcb1df310c2b73b4522b"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/3RW4RR3NNNBMRLTFLDECUQHLMR/bundle.json","state_url":"https://pith.science/pith/3RW4RR3NNNBMRLTFLDECUQHLMR/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/3RW4RR3NNNBMRLTFLDECUQHLMR/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-26T10:02:51Z","links":{"resolver":"https://pith.science/pith/3RW4RR3NNNBMRLTFLDECUQHLMR","bundle":"https://pith.science/pith/3RW4RR3NNNBMRLTFLDECUQHLMR/bundle.json","state":"https://pith.science/pith/3RW4RR3NNNBMRLTFLDECUQHLMR/state.json","well_known_bundle":"https://pith.science/.well-known/pith/3RW4RR3NNNBMRLTFLDECUQHLMR/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:3RW4RR3NNNBMRLTFLDECUQHLMR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"8d10670f98c0f8f5a51bfe98370005171071d865b459e1bd2e5f7f57bc4dd663","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2018-10-04T16:00:53Z","title_canon_sha256":"cadba14ab8f4307820e75a498a5850b347d2215bc65627662164430aad098b59"},"schema_version":"1.0","source":{"id":"1810.02285","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1810.02285","created_at":"2026-05-17T23:52:52Z"},{"alias_kind":"arxiv_version","alias_value":"1810.02285v2","created_at":"2026-05-17T23:52:52Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1810.02285","created_at":"2026-05-17T23:52:52Z"},{"alias_kind":"pith_short_12","alias_value":"3RW4RR3NNNBM","created_at":"2026-05-18T12:32:02Z"},{"alias_kind":"pith_short_16","alias_value":"3RW4RR3NNNBMRLTF","created_at":"2026-05-18T12:32:02Z"},{"alias_kind":"pith_short_8","alias_value":"3RW4RR3N","created_at":"2026-05-18T12:32:02Z"}],"graph_snapshots":[{"event_id":"sha256:4dd42689d682fd2325433f1a482aee5eb349df7a7255bcb1df310c2b73b4522b","target":"graph","created_at":"2026-05-17T23:52:52Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Developing targeted therapies based on patients' baseline characteristics and genomic profiles such as biomarkers has gained growing interests in recent years. Depending on patients' clinical characteristics, the expression of specific biomarkers or their combinations, different patient subgroups could respond differently to the same treatment. An ideal design, especially at the proof of concept stage, should search for such subgroups and make dynamic adaptation as the trial goes on. When no prior knowledge is available on whether the treatment works on the all-comer population or only works o","authors_text":"Florica Constantine, Yanxun Xu, Yili L. Pritchett, Yuan Yuan","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2018-10-04T16:00:53Z","title":"ASIED: A Bayesian Adaptive Subgroup-Identification Enrichment Design"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1810.02285","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:bfcdf9d960c3330d01f6f4d01599a450869876cd222847676b0a843adfa52db5","target":"record","created_at":"2026-05-17T23:52:52Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"8d10670f98c0f8f5a51bfe98370005171071d865b459e1bd2e5f7f57bc4dd663","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2018-10-04T16:00:53Z","title_canon_sha256":"cadba14ab8f4307820e75a498a5850b347d2215bc65627662164430aad098b59"},"schema_version":"1.0","source":{"id":"1810.02285","kind":"arxiv","version":2}},"canonical_sha256":"dc6dc8c76d6b42c8ae6558c82a40eb647273d1fe2a71ed4e1eb9c7c89a290349","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"dc6dc8c76d6b42c8ae6558c82a40eb647273d1fe2a71ed4e1eb9c7c89a290349","first_computed_at":"2026-05-17T23:52:52.005200Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:52:52.005200Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"lVH+dVGS7vBNCeQ80DSTbXqp84wuBSWrxXR5uFigPc0K3RDUfUggJXZny5xT6U5B2byW45OgrMjIkIkPiX8LBQ==","signature_status":"signed_v1","signed_at":"2026-05-17T23:52:52.006139Z","signed_message":"canonical_sha256_bytes"},"source_id":"1810.02285","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:bfcdf9d960c3330d01f6f4d01599a450869876cd222847676b0a843adfa52db5","sha256:4dd42689d682fd2325433f1a482aee5eb349df7a7255bcb1df310c2b73b4522b"],"state_sha256":"4cb7211db16a5708730489459f15449ea04893d9a94f58e5eebe6f7e6680e41f"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"imXQfLIeRrSEX5PfySK9D1yXwPqSONQYB1GhpdLkSHgNOZzx/WSztFDzChUzC8EzqyMgn1d9OTjUgdCzfy2lDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-26T10:02:51.093701Z","bundle_sha256":"81798a4fa31975ce71fe5b717365c15961d37e34249c3767bcda560134b4de87"}}