{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:3X22A6UNV7SQHR66RDB5GTGQWE","short_pith_number":"pith:3X22A6UN","canonical_record":{"source":{"id":"2505.05782","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-05-09T04:53:40Z","cross_cats_sorted":[],"title_canon_sha256":"87275dbd2e8e672db4f1a6f5fa3653b8722b9eae1f5eafc93443ac0e5e503bd1","abstract_canon_sha256":"575d2934ba7cc39283292f4fe4ceaeaddf8824103f8ce19b9f4ba8aeb4754343"},"schema_version":"1.0"},"canonical_sha256":"ddf5a07a8dafe503c7de88c3d34cd0b1123854932ff3ad6da32a8381b2706109","source":{"kind":"arxiv","id":"2505.05782","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.05782","created_at":"2026-07-05T11:00:47Z"},{"alias_kind":"arxiv_version","alias_value":"2505.05782v1","created_at":"2026-07-05T11:00:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.05782","created_at":"2026-07-05T11:00:47Z"},{"alias_kind":"pith_short_12","alias_value":"3X22A6UNV7SQ","created_at":"2026-07-05T11:00:47Z"},{"alias_kind":"pith_short_16","alias_value":"3X22A6UNV7SQHR66","created_at":"2026-07-05T11:00:47Z"},{"alias_kind":"pith_short_8","alias_value":"3X22A6UN","created_at":"2026-07-05T11:00:47Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:3X22A6UNV7SQHR66RDB5GTGQWE","target":"record","payload":{"canonical_record":{"source":{"id":"2505.05782","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-05-09T04:53:40Z","cross_cats_sorted":[],"title_canon_sha256":"87275dbd2e8e672db4f1a6f5fa3653b8722b9eae1f5eafc93443ac0e5e503bd1","abstract_canon_sha256":"575d2934ba7cc39283292f4fe4ceaeaddf8824103f8ce19b9f4ba8aeb4754343"},"schema_version":"1.0"},"canonical_sha256":"ddf5a07a8dafe503c7de88c3d34cd0b1123854932ff3ad6da32a8381b2706109","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:00:47.403211Z","signature_b64":"UPzIJXD2SV1dXSEDS76kGgai9Cn5xy1E5o20xmYkcSzWK3yaE/Q/VcYIh2QKifGZnmr4H1jh8KZnfH4U/nzFDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ddf5a07a8dafe503c7de88c3d34cd0b1123854932ff3ad6da32a8381b2706109","last_reissued_at":"2026-07-05T11:00:47.402726Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:00:47.402726Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2505.05782","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:00:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"6696gUH0/Ivyic9XG24Eb4Hons2a3xMFC5D061V6Ea3WruOzYXcCaYGPYCkvqsL98P6X+qIgoleyGqxglr8+Dg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-17T09:22:14.062158Z"},"content_sha256":"0bd0dc54cfc30eae1f8f5b29a5e25c63f96b153a3a0c81bedcabe58acda8339e","schema_version":"1.0","event_id":"sha256:0bd0dc54cfc30eae1f8f5b29a5e25c63f96b153a3a0c81bedcabe58acda8339e"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:3X22A6UNV7SQHR66RDB5GTGQWE","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Towards secondary structure prediction of longer mRNA sequences using a quantum-centric optimization scheme","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"quant-ph","authors_text":"Alexey Galda, Chris Cade, Dimitris Alevras, Eline Welling, Ido Niesen, Jae-eun Park, Mariana LaDue, Mihir Metkar, Saurabh Shivpuje, Triet Friedhoff, Vaibhaw Kumar, Wade Davis","submitted_at":"2025-05-09T04:53:40Z","abstract_excerpt":"Accurate prediction of mRNA secondary structure is critical for understanding gene expression, translation efficiency, and advancing mRNA-based therapeutics. However, the combinatorial complexity of possible foldings, especially in long sequences, poses significant computational challenges for classical algorithms. In this work, we propose a scalable, quantum-centric optimization framework that integrates quantum sampling with classical post-processing to tackle this problem. Building on a Quadratic Unconstrained Binary Optimization (QUBO) formulation of the mRNA folding task, we develop two c"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.05782","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2505.05782/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:00:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"8EyrhGXp9umqEojJg/wDB+am4wKmS3uroSzBkw6G//Y0re0Zm/hLMXMKQ/rQD/sGUBv3jJajiIH9/Jh2KDNWBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-17T09:22:14.062720Z"},"content_sha256":"d1cf47e97d57dd0cbed07cd5ac2f2e23123dc0d561946b9e7d926d2efbf8fd9a","schema_version":"1.0","event_id":"sha256:d1cf47e97d57dd0cbed07cd5ac2f2e23123dc0d561946b9e7d926d2efbf8fd9a"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/3X22A6UNV7SQHR66RDB5GTGQWE/bundle.json","state_url":"https://pith.science/pith/3X22A6UNV7SQHR66RDB5GTGQWE/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/3X22A6UNV7SQHR66RDB5GTGQWE/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-17T09:22:14Z","links":{"resolver":"https://pith.science/pith/3X22A6UNV7SQHR66RDB5GTGQWE","bundle":"https://pith.science/pith/3X22A6UNV7SQHR66RDB5GTGQWE/bundle.json","state":"https://pith.science/pith/3X22A6UNV7SQHR66RDB5GTGQWE/state.json","well_known_bundle":"https://pith.science/.well-known/pith/3X22A6UNV7SQHR66RDB5GTGQWE/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:3X22A6UNV7SQHR66RDB5GTGQWE","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"575d2934ba7cc39283292f4fe4ceaeaddf8824103f8ce19b9f4ba8aeb4754343","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-05-09T04:53:40Z","title_canon_sha256":"87275dbd2e8e672db4f1a6f5fa3653b8722b9eae1f5eafc93443ac0e5e503bd1"},"schema_version":"1.0","source":{"id":"2505.05782","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.05782","created_at":"2026-07-05T11:00:47Z"},{"alias_kind":"arxiv_version","alias_value":"2505.05782v1","created_at":"2026-07-05T11:00:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.05782","created_at":"2026-07-05T11:00:47Z"},{"alias_kind":"pith_short_12","alias_value":"3X22A6UNV7SQ","created_at":"2026-07-05T11:00:47Z"},{"alias_kind":"pith_short_16","alias_value":"3X22A6UNV7SQHR66","created_at":"2026-07-05T11:00:47Z"},{"alias_kind":"pith_short_8","alias_value":"3X22A6UN","created_at":"2026-07-05T11:00:47Z"}],"graph_snapshots":[{"event_id":"sha256:d1cf47e97d57dd0cbed07cd5ac2f2e23123dc0d561946b9e7d926d2efbf8fd9a","target":"graph","created_at":"2026-07-05T11:00:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2505.05782/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Accurate prediction of mRNA secondary structure is critical for understanding gene expression, translation efficiency, and advancing mRNA-based therapeutics. However, the combinatorial complexity of possible foldings, especially in long sequences, poses significant computational challenges for classical algorithms. In this work, we propose a scalable, quantum-centric optimization framework that integrates quantum sampling with classical post-processing to tackle this problem. Building on a Quadratic Unconstrained Binary Optimization (QUBO) formulation of the mRNA folding task, we develop two c","authors_text":"Alexey Galda, Chris Cade, Dimitris Alevras, Eline Welling, Ido Niesen, Jae-eun Park, Mariana LaDue, Mihir Metkar, Saurabh Shivpuje, Triet Friedhoff, Vaibhaw Kumar, Wade Davis","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-05-09T04:53:40Z","title":"Towards secondary structure prediction of longer mRNA sequences using a quantum-centric optimization scheme"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.05782","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0bd0dc54cfc30eae1f8f5b29a5e25c63f96b153a3a0c81bedcabe58acda8339e","target":"record","created_at":"2026-07-05T11:00:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"575d2934ba7cc39283292f4fe4ceaeaddf8824103f8ce19b9f4ba8aeb4754343","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"quant-ph","submitted_at":"2025-05-09T04:53:40Z","title_canon_sha256":"87275dbd2e8e672db4f1a6f5fa3653b8722b9eae1f5eafc93443ac0e5e503bd1"},"schema_version":"1.0","source":{"id":"2505.05782","kind":"arxiv","version":1}},"canonical_sha256":"ddf5a07a8dafe503c7de88c3d34cd0b1123854932ff3ad6da32a8381b2706109","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ddf5a07a8dafe503c7de88c3d34cd0b1123854932ff3ad6da32a8381b2706109","first_computed_at":"2026-07-05T11:00:47.402726Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:00:47.402726Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"UPzIJXD2SV1dXSEDS76kGgai9Cn5xy1E5o20xmYkcSzWK3yaE/Q/VcYIh2QKifGZnmr4H1jh8KZnfH4U/nzFDQ==","signature_status":"signed_v1","signed_at":"2026-07-05T11:00:47.403211Z","signed_message":"canonical_sha256_bytes"},"source_id":"2505.05782","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:0bd0dc54cfc30eae1f8f5b29a5e25c63f96b153a3a0c81bedcabe58acda8339e","sha256:d1cf47e97d57dd0cbed07cd5ac2f2e23123dc0d561946b9e7d926d2efbf8fd9a"],"state_sha256":"5f4f670b903a536b1870b021d2f96224e9d1712cdb9ccbcc3f8be9b8fcc2702a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"8r2EZra5VIyVhEUMQ2hoX/F9vhfYITWAygXy3Uy4wzEkwOI7g16bZK9NTG+akAyy8mhKoA70OJ2C30zE9ETTDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-17T09:22:14.066678Z","bundle_sha256":"18fd8573d97397305fd8168d0bedab6851fa5886d47c8a9ea4693a8a5c9e7fdc"}}