{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:3ZHHTKHZOTY6PCXQ7T4BC2CLST","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"631d9f4f204f63a656bf4f01dd4c6d7915b93f280347f14ef5fd27fe4b452d8e","cross_cats_sorted":["q-bio.MN"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2022-10-21T17:01:50Z","title_canon_sha256":"af79c710c3df634bee618fa2825a30540b75b5430fdc62d8029af7faebd600ec"},"schema_version":"1.0","source":{"id":"2210.12106","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2210.12106","created_at":"2026-07-05T05:09:09Z"},{"alias_kind":"arxiv_version","alias_value":"2210.12106v1","created_at":"2026-07-05T05:09:09Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2210.12106","created_at":"2026-07-05T05:09:09Z"},{"alias_kind":"pith_short_12","alias_value":"3ZHHTKHZOTY6","created_at":"2026-07-05T05:09:09Z"},{"alias_kind":"pith_short_16","alias_value":"3ZHHTKHZOTY6PCXQ","created_at":"2026-07-05T05:09:09Z"},{"alias_kind":"pith_short_8","alias_value":"3ZHHTKHZ","created_at":"2026-07-05T05:09:09Z"}],"graph_snapshots":[{"event_id":"sha256:6a4a4c2d1ce37186cb5f10de3e37f393e6543972ba7cd7ec75d4742b4e7721be","target":"graph","created_at":"2026-07-05T05:09:09Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2210.12106/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"There exist several methods for simulating biological and physical systems as represented by chemical reaction networks. Systems with low numbers of particles are frequently modelled as discrete-state Markov jump processes and are typically simulated via a stochastic simulation algorithm (SSA). An SSA, while accurate, is often unsuitable for systems with large numbers of individuals, and can become prohibitively expensive with increasing reaction frequency. Large systems are often modelled deterministically using ordinary differential equations, sacrificing accuracy and stochasticity for compu","authors_text":"Anna Hekkink, Chris Guiver, Christian A Yates, Joshua C. Kynaston","cross_cats":["q-bio.MN"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2022-10-21T17:01:50Z","title":"The mass-conversion method: a hybrid technique for simulating well-mixed chemical reaction networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2210.12106","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:17f1c0ae34866d3746c7b54c8ef205eb9bdbb3541ea1054bd75847c2a972d8e9","target":"record","created_at":"2026-07-05T05:09:09Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"631d9f4f204f63a656bf4f01dd4c6d7915b93f280347f14ef5fd27fe4b452d8e","cross_cats_sorted":["q-bio.MN"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2022-10-21T17:01:50Z","title_canon_sha256":"af79c710c3df634bee618fa2825a30540b75b5430fdc62d8029af7faebd600ec"},"schema_version":"1.0","source":{"id":"2210.12106","kind":"arxiv","version":1}},"canonical_sha256":"de4e79a8f974f1e78af0fcf811684b94f82dd437a8efbddedf36f37c98829c9c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"de4e79a8f974f1e78af0fcf811684b94f82dd437a8efbddedf36f37c98829c9c","first_computed_at":"2026-07-05T05:09:09.398417Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T05:09:09.398417Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"2Fo+AIy09tODFphsJ6g34XZeBdO8S1QKIR2TKlP1xq8smcdJ689TC8a61msXd8dp3yBM6i6bMoGEdlfxWCE3Aw==","signature_status":"signed_v1","signed_at":"2026-07-05T05:09:09.398768Z","signed_message":"canonical_sha256_bytes"},"source_id":"2210.12106","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:17f1c0ae34866d3746c7b54c8ef205eb9bdbb3541ea1054bd75847c2a972d8e9","sha256:6a4a4c2d1ce37186cb5f10de3e37f393e6543972ba7cd7ec75d4742b4e7721be"],"state_sha256":"afc4615966f4938403c8ab24b7dd211958d699ab125b82948117f7e38e3595f1"}