{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:43VOA5JSQUKFXMLH34ISNLBKV2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c067134da5c8735556e0b9c4540f8507e3fad572393473c17dbf4ee1b61d1250","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2018-03-05T17:00:45Z","title_canon_sha256":"45c476489edfcf7aa59604cd787bf55ab6e4cb16809820c04e0577fe59512daa"},"schema_version":"1.0","source":{"id":"1803.01776","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1803.01776","created_at":"2026-05-18T00:10:54Z"},{"alias_kind":"arxiv_version","alias_value":"1803.01776v2","created_at":"2026-05-18T00:10:54Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1803.01776","created_at":"2026-05-18T00:10:54Z"},{"alias_kind":"pith_short_12","alias_value":"43VOA5JSQUKF","created_at":"2026-05-18T12:32:05Z"},{"alias_kind":"pith_short_16","alias_value":"43VOA5JSQUKFXMLH","created_at":"2026-05-18T12:32:05Z"},{"alias_kind":"pith_short_8","alias_value":"43VOA5JS","created_at":"2026-05-18T12:32:05Z"}],"graph_snapshots":[{"event_id":"sha256:ce8c13fe8db078a1a5ed06231d73a6a1e09a3832cbba285dcdf3d3ad945b232d","target":"graph","created_at":"2026-05-18T00:10:54Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Point source localization is a problem of persistent interest in optical imaging. In particular, a number of widely used biological microscopy techniques rely on precise three-dimensional localization of single fluorophores. As emitter depth localization is more challenging than lateral localization, considerable effort has been spent on engineering the response of the microscope in a way that reveals increased depth information. Here we consider the theoretical limits of such approaches by deriving the quantum Cram\\'{e}r-Rao bound (QCRB). We show that existing methods for depth localization w","authors_text":"Mikael P. Backlund, Ronald L. Walsworth, Yoav Shechtman","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2018-03-05T17:00:45Z","title":"Fundamental precision bounds for three-dimensional optical localization microscopy with Poisson statistics"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1803.01776","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:dc29512b73eda2bee69b53df2cf986f1947de0f4f0af71a8644093e6cc0258da","target":"record","created_at":"2026-05-18T00:10:54Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c067134da5c8735556e0b9c4540f8507e3fad572393473c17dbf4ee1b61d1250","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2018-03-05T17:00:45Z","title_canon_sha256":"45c476489edfcf7aa59604cd787bf55ab6e4cb16809820c04e0577fe59512daa"},"schema_version":"1.0","source":{"id":"1803.01776","kind":"arxiv","version":2}},"canonical_sha256":"e6eae0753285145bb167df1126ac2aaea75aca627bc317828b1b5e5539d4bbb8","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e6eae0753285145bb167df1126ac2aaea75aca627bc317828b1b5e5539d4bbb8","first_computed_at":"2026-05-18T00:10:54.488770Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:10:54.488770Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"bqFqO8Q9NwAUMJfBCUj3x/CKH4ESwdPpaD6rqtyJ+FOXvYZ1hpjyLwBjdTGHonC6eFgxITIIaYJlH16CsCpmAA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:10:54.489469Z","signed_message":"canonical_sha256_bytes"},"source_id":"1803.01776","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:dc29512b73eda2bee69b53df2cf986f1947de0f4f0af71a8644093e6cc0258da","sha256:ce8c13fe8db078a1a5ed06231d73a6a1e09a3832cbba285dcdf3d3ad945b232d"],"state_sha256":"8466069d1d0498a3fdf545f865dbf306a59f0495d072b7031d97affb2e97e583"}