{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:46LKO3WYLIZPMAVUIG6CCA7NZS","short_pith_number":"pith:46LKO3WY","canonical_record":{"source":{"id":"1306.0069","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-06-01T03:14:59Z","cross_cats_sorted":["q-bio.PE"],"title_canon_sha256":"eb5e3df809f50f2429ee95448678a98c2408c33c08136835a2ce670df002803f","abstract_canon_sha256":"6257b44a232b396e2c71db429b2c97478390385932a52d5dfd6852d1a18ddbb1"},"schema_version":"1.0"},"canonical_sha256":"e796a76ed85a32f602b441bc2103edccb2c36e4a30d790d57757aef24619422f","source":{"kind":"arxiv","id":"1306.0069","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1306.0069","created_at":"2026-05-18T03:22:04Z"},{"alias_kind":"arxiv_version","alias_value":"1306.0069v1","created_at":"2026-05-18T03:22:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1306.0069","created_at":"2026-05-18T03:22:04Z"},{"alias_kind":"pith_short_12","alias_value":"46LKO3WYLIZP","created_at":"2026-05-18T12:27:32Z"},{"alias_kind":"pith_short_16","alias_value":"46LKO3WYLIZPMAVU","created_at":"2026-05-18T12:27:32Z"},{"alias_kind":"pith_short_8","alias_value":"46LKO3WY","created_at":"2026-05-18T12:27:32Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:46LKO3WYLIZPMAVUIG6CCA7NZS","target":"record","payload":{"canonical_record":{"source":{"id":"1306.0069","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-06-01T03:14:59Z","cross_cats_sorted":["q-bio.PE"],"title_canon_sha256":"eb5e3df809f50f2429ee95448678a98c2408c33c08136835a2ce670df002803f","abstract_canon_sha256":"6257b44a232b396e2c71db429b2c97478390385932a52d5dfd6852d1a18ddbb1"},"schema_version":"1.0"},"canonical_sha256":"e796a76ed85a32f602b441bc2103edccb2c36e4a30d790d57757aef24619422f","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:22:04.718377Z","signature_b64":"NLkhAqqdod1JfaYYLxGju4uvXAZJEl5fXF8EGdaw2X8au6AiEoLnLO964QSzg6m4paTtCnxoFPRWwUK+5eC+BA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"e796a76ed85a32f602b441bc2103edccb2c36e4a30d790d57757aef24619422f","last_reissued_at":"2026-05-18T03:22:04.717422Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:22:04.717422Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1306.0069","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:22:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"dpNhnHywdnSp290+T7GRQdbzC2YQTzK281sMCP+5AD1/9SUVkKFHI1+UzMz0K2McdVcVtkCV5Xf9iH2weLONBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T19:16:31.905650Z"},"content_sha256":"68367153ba105301da3a4b844c362fdb524a39fb081ecebc0f1232207ad51c37","schema_version":"1.0","event_id":"sha256:68367153ba105301da3a4b844c362fdb524a39fb081ecebc0f1232207ad51c37"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:46LKO3WYLIZPMAVUIG6CCA7NZS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Statistical Methods for Estimating Complexity from Competition Experiments between Two Populations","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.PE"],"primary_cat":"q-bio.QM","authors_text":"Francis J. Schmidt, Stephen Montgomery-Smith","submitted_at":"2013-06-01T03:14:59Z","abstract_excerpt":"Often a screening or selection experiment targets a cell or tissue, which presents many possible molecular targets and identifies a correspondingly large number of ligands. We describe a statistical method to extract an estimate of the complexity or richness of the set of molecular targets from competition experiments between distinguishable ligands, including aptamers derived from combinatorial experiments (SELEX or phage display). In simulations, the nonparametric statistic provides a robust estimate of complexity from a 100x100 matrix of competition experiments, which is clearly feasible in"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1306.0069","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:22:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"CEV9G2SoQZGqgUrG0hcRTInO9mj5y+KDClgktfpdWsyfqjKnAylutiRPhKT0izTew5gCMOdgAc9DmMSwelqGBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T19:16:31.906343Z"},"content_sha256":"840cb39b7903cdce56bb7d41a22133874d90f25d431e79db0da292d80242db42","schema_version":"1.0","event_id":"sha256:840cb39b7903cdce56bb7d41a22133874d90f25d431e79db0da292d80242db42"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/46LKO3WYLIZPMAVUIG6CCA7NZS/bundle.json","state_url":"https://pith.science/pith/46LKO3WYLIZPMAVUIG6CCA7NZS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/46LKO3WYLIZPMAVUIG6CCA7NZS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-26T19:16:31Z","links":{"resolver":"https://pith.science/pith/46LKO3WYLIZPMAVUIG6CCA7NZS","bundle":"https://pith.science/pith/46LKO3WYLIZPMAVUIG6CCA7NZS/bundle.json","state":"https://pith.science/pith/46LKO3WYLIZPMAVUIG6CCA7NZS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/46LKO3WYLIZPMAVUIG6CCA7NZS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:46LKO3WYLIZPMAVUIG6CCA7NZS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6257b44a232b396e2c71db429b2c97478390385932a52d5dfd6852d1a18ddbb1","cross_cats_sorted":["q-bio.PE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-06-01T03:14:59Z","title_canon_sha256":"eb5e3df809f50f2429ee95448678a98c2408c33c08136835a2ce670df002803f"},"schema_version":"1.0","source":{"id":"1306.0069","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1306.0069","created_at":"2026-05-18T03:22:04Z"},{"alias_kind":"arxiv_version","alias_value":"1306.0069v1","created_at":"2026-05-18T03:22:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1306.0069","created_at":"2026-05-18T03:22:04Z"},{"alias_kind":"pith_short_12","alias_value":"46LKO3WYLIZP","created_at":"2026-05-18T12:27:32Z"},{"alias_kind":"pith_short_16","alias_value":"46LKO3WYLIZPMAVU","created_at":"2026-05-18T12:27:32Z"},{"alias_kind":"pith_short_8","alias_value":"46LKO3WY","created_at":"2026-05-18T12:27:32Z"}],"graph_snapshots":[{"event_id":"sha256:840cb39b7903cdce56bb7d41a22133874d90f25d431e79db0da292d80242db42","target":"graph","created_at":"2026-05-18T03:22:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Often a screening or selection experiment targets a cell or tissue, which presents many possible molecular targets and identifies a correspondingly large number of ligands. We describe a statistical method to extract an estimate of the complexity or richness of the set of molecular targets from competition experiments between distinguishable ligands, including aptamers derived from combinatorial experiments (SELEX or phage display). In simulations, the nonparametric statistic provides a robust estimate of complexity from a 100x100 matrix of competition experiments, which is clearly feasible in","authors_text":"Francis J. Schmidt, Stephen Montgomery-Smith","cross_cats":["q-bio.PE"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-06-01T03:14:59Z","title":"Statistical Methods for Estimating Complexity from Competition Experiments between Two Populations"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1306.0069","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:68367153ba105301da3a4b844c362fdb524a39fb081ecebc0f1232207ad51c37","target":"record","created_at":"2026-05-18T03:22:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6257b44a232b396e2c71db429b2c97478390385932a52d5dfd6852d1a18ddbb1","cross_cats_sorted":["q-bio.PE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-06-01T03:14:59Z","title_canon_sha256":"eb5e3df809f50f2429ee95448678a98c2408c33c08136835a2ce670df002803f"},"schema_version":"1.0","source":{"id":"1306.0069","kind":"arxiv","version":1}},"canonical_sha256":"e796a76ed85a32f602b441bc2103edccb2c36e4a30d790d57757aef24619422f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e796a76ed85a32f602b441bc2103edccb2c36e4a30d790d57757aef24619422f","first_computed_at":"2026-05-18T03:22:04.717422Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:22:04.717422Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"NLkhAqqdod1JfaYYLxGju4uvXAZJEl5fXF8EGdaw2X8au6AiEoLnLO964QSzg6m4paTtCnxoFPRWwUK+5eC+BA==","signature_status":"signed_v1","signed_at":"2026-05-18T03:22:04.718377Z","signed_message":"canonical_sha256_bytes"},"source_id":"1306.0069","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:68367153ba105301da3a4b844c362fdb524a39fb081ecebc0f1232207ad51c37","sha256:840cb39b7903cdce56bb7d41a22133874d90f25d431e79db0da292d80242db42"],"state_sha256":"ced946be671bf720c18cdbfd4cc79c6a24b70e3b5564c49ff9e6c92f3736bf53"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kObZGEe6TIySDEw5RtEZA0bHQ4fSCXpPKnHG6AarJ9rv5gYM8JdRq8N4tyHbSAvsgikZV3yL+ghJVXiMwt05Cw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-26T19:16:31.909950Z","bundle_sha256":"e85b02fe654bcfa178a12a40ff0d1632ef358d409dad66d8b8cccb2c4d7e6cad"}}