{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:47AC45FBHTCTAEKSROGUDMS3Y4","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c987cb1338f5c283f1784c5d70ad2dae09dd3495e061c68ed207ccd58b0f43d7","cross_cats_sorted":["cond-mat.soft","q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-12-03T23:33:37Z","title_canon_sha256":"2ac025d7017c8faa7f787256839d93d680934e8ab890fbd5053de52d6495f308"},"schema_version":"1.0","source":{"id":"1412.1518","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1412.1518","created_at":"2026-05-18T01:41:23Z"},{"alias_kind":"arxiv_version","alias_value":"1412.1518v1","created_at":"2026-05-18T01:41:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1412.1518","created_at":"2026-05-18T01:41:23Z"},{"alias_kind":"pith_short_12","alias_value":"47AC45FBHTCT","created_at":"2026-05-18T12:28:14Z"},{"alias_kind":"pith_short_16","alias_value":"47AC45FBHTCTAEKS","created_at":"2026-05-18T12:28:14Z"},{"alias_kind":"pith_short_8","alias_value":"47AC45FB","created_at":"2026-05-18T12:28:14Z"}],"graph_snapshots":[{"event_id":"sha256:e381da93a706db21cf8d4e30e5b72836fe7bf52bc7a3cbb2ac5ace100963a76a","target":"graph","created_at":"2026-05-18T01:41:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The letter resolves the long standing debate as to the proper time scale ($<\\tau>$) of the onset of the immunological synapse (IS) bond, the non-covalent chemical bond defining the immune pathways involving T-cells and antigen presenting cells (APC). Results from our model calculations show $<\\tau>$ to be of the order of seconds instead of minutes. Close to the linearly stable regime, we show that in between the two critical spatial thresholds defined by the integrin:ligand pair ($\\Delta_2\\sim$ 40-45 nm) and the T cell receptor (TCR):pMHC bond ($\\Delta_1\\sim$ 14-15 nm), $<\\tau>$ grows monotoni","authors_text":"Amit K. Chattopadhyay, Daniel R. Bush","cross_cats":["cond-mat.soft","q-bio.CB"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-12-03T23:33:37Z","title":"Close Contact Fluctuations: Time of Contact"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1412.1518","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:7b0b0f1bbfceb8fd9b7d9f634ae2b6d1ae1a14adc88adcc96149c3a7e3ab03f6","target":"record","created_at":"2026-05-18T01:41:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c987cb1338f5c283f1784c5d70ad2dae09dd3495e061c68ed207ccd58b0f43d7","cross_cats_sorted":["cond-mat.soft","q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2014-12-03T23:33:37Z","title_canon_sha256":"2ac025d7017c8faa7f787256839d93d680934e8ab890fbd5053de52d6495f308"},"schema_version":"1.0","source":{"id":"1412.1518","kind":"arxiv","version":1}},"canonical_sha256":"e7c02e74a13cc53011528b8d41b25bc71ee4550405fa2c5d394bfc8126eaf89b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e7c02e74a13cc53011528b8d41b25bc71ee4550405fa2c5d394bfc8126eaf89b","first_computed_at":"2026-05-18T01:41:23.475681Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:41:23.475681Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"KK1iEJG1g9tVQ4tn4a/aAToZBbjRhtBgd19Tz2975dmCanVt7Z6X0tdiaCKLZR91WaYMzYFWiC9/GYyjlpgKAA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:41:23.476411Z","signed_message":"canonical_sha256_bytes"},"source_id":"1412.1518","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:7b0b0f1bbfceb8fd9b7d9f634ae2b6d1ae1a14adc88adcc96149c3a7e3ab03f6","sha256:e381da93a706db21cf8d4e30e5b72836fe7bf52bc7a3cbb2ac5ace100963a76a"],"state_sha256":"2709b9ef2e84b5e425def011c698369b5eef81f64e830b3053f8dfaf87bc89a1"}