{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:4CRIIULPEL4G5GHNAVSFQGXCVE","short_pith_number":"pith:4CRIIULP","canonical_record":{"source":{"id":"2606.08138","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2026-06-06T12:31:51Z","cross_cats_sorted":["physics.app-ph","q-bio.SC"],"title_canon_sha256":"66c7654088e3d962afc41d6f22c4f9ae0a43aebc8bf564213b0272ebc602b6db","abstract_canon_sha256":"01a1b45ad86c61f05f08c4d5ae43ddb581268f746e5d5f701b99b9bf3603d2c3"},"schema_version":"1.0"},"canonical_sha256":"e0a284516f22f86e98ed0564581ae2a91265d88f5e82ee1d4f97fc98c64630de","source":{"kind":"arxiv","id":"2606.08138","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.08138","created_at":"2026-06-09T01:05:27Z"},{"alias_kind":"arxiv_version","alias_value":"2606.08138v1","created_at":"2026-06-09T01:05:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.08138","created_at":"2026-06-09T01:05:27Z"},{"alias_kind":"pith_short_12","alias_value":"4CRIIULPEL4G","created_at":"2026-06-09T01:05:27Z"},{"alias_kind":"pith_short_16","alias_value":"4CRIIULPEL4G5GHN","created_at":"2026-06-09T01:05:27Z"},{"alias_kind":"pith_short_8","alias_value":"4CRIIULP","created_at":"2026-06-09T01:05:27Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:4CRIIULPEL4G5GHNAVSFQGXCVE","target":"record","payload":{"canonical_record":{"source":{"id":"2606.08138","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2026-06-06T12:31:51Z","cross_cats_sorted":["physics.app-ph","q-bio.SC"],"title_canon_sha256":"66c7654088e3d962afc41d6f22c4f9ae0a43aebc8bf564213b0272ebc602b6db","abstract_canon_sha256":"01a1b45ad86c61f05f08c4d5ae43ddb581268f746e5d5f701b99b9bf3603d2c3"},"schema_version":"1.0"},"canonical_sha256":"e0a284516f22f86e98ed0564581ae2a91265d88f5e82ee1d4f97fc98c64630de","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-09T01:05:27.816685Z","signature_b64":"YqNCMmNCP+F0hC0POelJA8HBavqTEUkMdDpF3hDhv3Cj0UpWi4/ZekKBM+GCxpoPUO94GjiO53LgHAHB+f47BQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"e0a284516f22f86e98ed0564581ae2a91265d88f5e82ee1d4f97fc98c64630de","last_reissued_at":"2026-06-09T01:05:27.815992Z","signature_status":"signed_v1","first_computed_at":"2026-06-09T01:05:27.815992Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2606.08138","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-09T01:05:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"eTDTEcqrmcOXboUpuFJW7zoFVShBCBSJPUjhtcNiZUNVmUdGU/j585dhkChGU3q5mCo8Sa5tRiUFLwWApQHpAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T14:14:08.871042Z"},"content_sha256":"67db369b3d607e0cf887734203d5e11c020fb5ae93a05a73d76dec85dfe44ffd","schema_version":"1.0","event_id":"sha256:67db369b3d607e0cf887734203d5e11c020fb5ae93a05a73d76dec85dfe44ffd"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:4CRIIULPEL4G5GHNAVSFQGXCVE","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"DNA Replication under Thermal, Chemical, and Genotoxic Stress","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["physics.app-ph","q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"Anupam Gupta, Bhakti Mehta, Chinmaya Pradhan, Mrinal Srivastava, Nirjharini Saha","submitted_at":"2026-06-06T12:31:51Z","abstract_excerpt":"Eukaryotic DNA replication must remain robust under thermal, chemical, and genotoxic stress despite large fluctuations in replication dynamics. Here, we develop a lattice-based stochastic Monte Carlo framework for whole-genome replication in Saccharomyces cerevisiae at single base-pair resolution, incorporating probabilistic origin firing, replication fork-speed distributions, and a time-dependent limiting factor that governs the availability of cellular replication resources. The model is benchmarked quantitatively against experimental replication profiles before being applied to stress condi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.08138","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.08138/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-09T01:05:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"1zbfejC66rq6yszz9RkCBJblHgJn3gXmGpEbp3HSK2BYJiLB2X5B6ScwqzKeZ5Wv2TE3EbDVi7txJvFIXdFmAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T14:14:08.871424Z"},"content_sha256":"f35618c7fb46f35d6de04de15af655974037920a41265bbeff4826cbe9b2f3e1","schema_version":"1.0","event_id":"sha256:f35618c7fb46f35d6de04de15af655974037920a41265bbeff4826cbe9b2f3e1"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/4CRIIULPEL4G5GHNAVSFQGXCVE/bundle.json","state_url":"https://pith.science/pith/4CRIIULPEL4G5GHNAVSFQGXCVE/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/4CRIIULPEL4G5GHNAVSFQGXCVE/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-09T14:14:08Z","links":{"resolver":"https://pith.science/pith/4CRIIULPEL4G5GHNAVSFQGXCVE","bundle":"https://pith.science/pith/4CRIIULPEL4G5GHNAVSFQGXCVE/bundle.json","state":"https://pith.science/pith/4CRIIULPEL4G5GHNAVSFQGXCVE/state.json","well_known_bundle":"https://pith.science/.well-known/pith/4CRIIULPEL4G5GHNAVSFQGXCVE/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:4CRIIULPEL4G5GHNAVSFQGXCVE","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"01a1b45ad86c61f05f08c4d5ae43ddb581268f746e5d5f701b99b9bf3603d2c3","cross_cats_sorted":["physics.app-ph","q-bio.SC"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2026-06-06T12:31:51Z","title_canon_sha256":"66c7654088e3d962afc41d6f22c4f9ae0a43aebc8bf564213b0272ebc602b6db"},"schema_version":"1.0","source":{"id":"2606.08138","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.08138","created_at":"2026-06-09T01:05:27Z"},{"alias_kind":"arxiv_version","alias_value":"2606.08138v1","created_at":"2026-06-09T01:05:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.08138","created_at":"2026-06-09T01:05:27Z"},{"alias_kind":"pith_short_12","alias_value":"4CRIIULPEL4G","created_at":"2026-06-09T01:05:27Z"},{"alias_kind":"pith_short_16","alias_value":"4CRIIULPEL4G5GHN","created_at":"2026-06-09T01:05:27Z"},{"alias_kind":"pith_short_8","alias_value":"4CRIIULP","created_at":"2026-06-09T01:05:27Z"}],"graph_snapshots":[{"event_id":"sha256:f35618c7fb46f35d6de04de15af655974037920a41265bbeff4826cbe9b2f3e1","target":"graph","created_at":"2026-06-09T01:05:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.08138/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Eukaryotic DNA replication must remain robust under thermal, chemical, and genotoxic stress despite large fluctuations in replication dynamics. Here, we develop a lattice-based stochastic Monte Carlo framework for whole-genome replication in Saccharomyces cerevisiae at single base-pair resolution, incorporating probabilistic origin firing, replication fork-speed distributions, and a time-dependent limiting factor that governs the availability of cellular replication resources. The model is benchmarked quantitatively against experimental replication profiles before being applied to stress condi","authors_text":"Anupam Gupta, Bhakti Mehta, Chinmaya Pradhan, Mrinal Srivastava, Nirjharini Saha","cross_cats":["physics.app-ph","q-bio.SC"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2026-06-06T12:31:51Z","title":"DNA Replication under Thermal, Chemical, and Genotoxic Stress"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.08138","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:67db369b3d607e0cf887734203d5e11c020fb5ae93a05a73d76dec85dfe44ffd","target":"record","created_at":"2026-06-09T01:05:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"01a1b45ad86c61f05f08c4d5ae43ddb581268f746e5d5f701b99b9bf3603d2c3","cross_cats_sorted":["physics.app-ph","q-bio.SC"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2026-06-06T12:31:51Z","title_canon_sha256":"66c7654088e3d962afc41d6f22c4f9ae0a43aebc8bf564213b0272ebc602b6db"},"schema_version":"1.0","source":{"id":"2606.08138","kind":"arxiv","version":1}},"canonical_sha256":"e0a284516f22f86e98ed0564581ae2a91265d88f5e82ee1d4f97fc98c64630de","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e0a284516f22f86e98ed0564581ae2a91265d88f5e82ee1d4f97fc98c64630de","first_computed_at":"2026-06-09T01:05:27.815992Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-09T01:05:27.815992Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"YqNCMmNCP+F0hC0POelJA8HBavqTEUkMdDpF3hDhv3Cj0UpWi4/ZekKBM+GCxpoPUO94GjiO53LgHAHB+f47BQ==","signature_status":"signed_v1","signed_at":"2026-06-09T01:05:27.816685Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.08138","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:67db369b3d607e0cf887734203d5e11c020fb5ae93a05a73d76dec85dfe44ffd","sha256:f35618c7fb46f35d6de04de15af655974037920a41265bbeff4826cbe9b2f3e1"],"state_sha256":"0c5805c6f3dd8e750b784e3bb15d948d0e9f5446f22eedbcd0c18ebc556bb374"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"CrErHIatpO4LavMuqRi01n6vlnI+6ZPM6bYgS5I8iIKKeDX1wPu2whPwHGA1OxS293DiCzhYoq4YKv/05YRNBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-09T14:14:08.873356Z","bundle_sha256":"dc67816aa82067e983aa0439dc41f0b7bcd4d6b9ec3cb30cef295b9a3da1efc7"}}