{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:4HRQVBE35IWNUB6AH2C27LNWBD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"792c81b54e7e151f6438afc584601310864b49614d2b82f99dda06b25bad7f6b","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2019-04-11T15:44:46Z","title_canon_sha256":"bc591f7d46a5bbd154710658d15b91ff1e4b320a67f52efa81523c70a12d0904"},"schema_version":"1.0","source":{"id":"1904.05789","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1904.05789","created_at":"2026-05-17T23:48:48Z"},{"alias_kind":"arxiv_version","alias_value":"1904.05789v1","created_at":"2026-05-17T23:48:48Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1904.05789","created_at":"2026-05-17T23:48:48Z"},{"alias_kind":"pith_short_12","alias_value":"4HRQVBE35IWN","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_16","alias_value":"4HRQVBE35IWNUB6A","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_8","alias_value":"4HRQVBE3","created_at":"2026-05-18T12:33:10Z"}],"graph_snapshots":[{"event_id":"sha256:ca5d39e756c9997baeefaede6c5bc258c23955e009539b4d9fd461ac42979427","target":"graph","created_at":"2026-05-17T23:48:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Purpose: This study assessed the dosimetric accuracy of synthetic CT images generated from magnetic resonance imaging (MRI) data for focal brain radiation therapy, using a deep learning approach. Material and Methods: We conducted a study in 77 patients with brain tumors who had undergone both MRI and computed tomography (CT) imaging as part of their simulation for external beam treatment planning. We designed a generative adversarial network (GAN) to generate synthetic CT images from MRI images. We used Mutual Information (MI) as the loss function in the generator to overcome the misalignment","authors_text":"Amir Owrangi, Dan Nguyen, Robert Timmerman, Samaneh Kazemifar, Sarah McGuire, Steve Jiang, Yang Park, Zabi Wardak","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2019-04-11T15:44:46Z","title":"MRI-only brain radiotherapy: assessing the dosimetric accuracy of synthetic CT images generated using a deep learning approach"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1904.05789","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5d3477d17747c99f9e6126912febbaedae04b4fc0e8459f00629ac3acd0f0ecc","target":"record","created_at":"2026-05-17T23:48:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"792c81b54e7e151f6438afc584601310864b49614d2b82f99dda06b25bad7f6b","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2019-04-11T15:44:46Z","title_canon_sha256":"bc591f7d46a5bbd154710658d15b91ff1e4b320a67f52efa81523c70a12d0904"},"schema_version":"1.0","source":{"id":"1904.05789","kind":"arxiv","version":1}},"canonical_sha256":"e1e30a849bea2cda07c03e85afadb608f432f157d0df4218690d858daa4fff9c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e1e30a849bea2cda07c03e85afadb608f432f157d0df4218690d858daa4fff9c","first_computed_at":"2026-05-17T23:48:48.434340Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:48:48.434340Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"K9gjaSuH41cifau2VryOGSkxYXNTciF2S7cJEC78MKqvTl4aAw8fGgzMMYKtaTHDYMQ5wE5SRYipL8T0zBY9Cw==","signature_status":"signed_v1","signed_at":"2026-05-17T23:48:48.434785Z","signed_message":"canonical_sha256_bytes"},"source_id":"1904.05789","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5d3477d17747c99f9e6126912febbaedae04b4fc0e8459f00629ac3acd0f0ecc","sha256:ca5d39e756c9997baeefaede6c5bc258c23955e009539b4d9fd461ac42979427"],"state_sha256":"70be977ae24fb8423040b3e87aeea447e0b9369f20bf10514593a4b624740e5e"}