{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:4LEDQXAON64BZ5UITZT2VJGUV3","short_pith_number":"pith:4LEDQXAO","canonical_record":{"source":{"id":"1710.02436","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-10-06T14:53:20Z","cross_cats_sorted":[],"title_canon_sha256":"9726524f5e99c11ec42d23cb59c2658e1acfd0ac72631367b33a1007b7df5289","abstract_canon_sha256":"a4628f830d8697a3c74d176da770d3838c7384fe860b0feeb384229ff66fa407"},"schema_version":"1.0"},"canonical_sha256":"e2c8385c0e6fb81cf6889e67aaa4d4aec85380980fdf7f5245d1a24895fc3e4b","source":{"kind":"arxiv","id":"1710.02436","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1710.02436","created_at":"2026-05-18T00:33:33Z"},{"alias_kind":"arxiv_version","alias_value":"1710.02436v1","created_at":"2026-05-18T00:33:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1710.02436","created_at":"2026-05-18T00:33:33Z"},{"alias_kind":"pith_short_12","alias_value":"4LEDQXAON64B","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_16","alias_value":"4LEDQXAON64BZ5UI","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_8","alias_value":"4LEDQXAO","created_at":"2026-05-18T12:31:00Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:4LEDQXAON64BZ5UITZT2VJGUV3","target":"record","payload":{"canonical_record":{"source":{"id":"1710.02436","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-10-06T14:53:20Z","cross_cats_sorted":[],"title_canon_sha256":"9726524f5e99c11ec42d23cb59c2658e1acfd0ac72631367b33a1007b7df5289","abstract_canon_sha256":"a4628f830d8697a3c74d176da770d3838c7384fe860b0feeb384229ff66fa407"},"schema_version":"1.0"},"canonical_sha256":"e2c8385c0e6fb81cf6889e67aaa4d4aec85380980fdf7f5245d1a24895fc3e4b","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:33:33.421268Z","signature_b64":"U/s2/tLXtRFRYFdSaqvygXOhKwplXEdSbr9qXDLrxqK6gPyoE58nWXLKlETBmy2lmMj6pONUJ/U3/ao2xwGMAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"e2c8385c0e6fb81cf6889e67aaa4d4aec85380980fdf7f5245d1a24895fc3e4b","last_reissued_at":"2026-05-18T00:33:33.420699Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:33:33.420699Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1710.02436","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:33:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"RYR0DK+oHvKS31dSDouKu9euT1MOpV2DcTYvE74U78dE083Vp2YxaUaRxJI7QGrOYmCbAtKgocw66SXk3f4vDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T15:22:43.076389Z"},"content_sha256":"564bd3ab0ab1caed00ea2bdbb634e1b4dbac172991a8c9075be726f358d31885","schema_version":"1.0","event_id":"sha256:564bd3ab0ab1caed00ea2bdbb634e1b4dbac172991a8c9075be726f358d31885"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:4LEDQXAON64BZ5UITZT2VJGUV3","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Frustration, function and folding","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Diego U. Ferreiro, Elizabeth A. Komives, Peter G. Wolynes","submitted_at":"2017-10-06T14:53:20Z","abstract_excerpt":"Natural protein molecules are exceptional polymers. Encoded in apparently random strings of amino-acids, these objects perform clear physical tasks that are rare to find by simple chance. Accurate folding, specific binding, powerful catalysis, are examples of basic chemical activities that the great majority of polypeptides do not display, and are thought to be the outcome of the natural history of proteins. Function, a concept genuine to Biology, is at the core of evolution and often conflicts with the physical constraints. Locating the frustration between discrepant goals in a recurrent syst"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1710.02436","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:33:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"En2oDcG9FZLSg5XrDMaXXrPyOANGWoWv2NN8IIejYvuIVcyModPJ41xvwYjFLabscR+DdKg+YZytL17MnrS/Bg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T15:22:43.077079Z"},"content_sha256":"6cc0c2984cfe1437b226233906242d7ac9102e2f2d282b54fa2f920795acf433","schema_version":"1.0","event_id":"sha256:6cc0c2984cfe1437b226233906242d7ac9102e2f2d282b54fa2f920795acf433"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/4LEDQXAON64BZ5UITZT2VJGUV3/bundle.json","state_url":"https://pith.science/pith/4LEDQXAON64BZ5UITZT2VJGUV3/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/4LEDQXAON64BZ5UITZT2VJGUV3/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-26T15:22:43Z","links":{"resolver":"https://pith.science/pith/4LEDQXAON64BZ5UITZT2VJGUV3","bundle":"https://pith.science/pith/4LEDQXAON64BZ5UITZT2VJGUV3/bundle.json","state":"https://pith.science/pith/4LEDQXAON64BZ5UITZT2VJGUV3/state.json","well_known_bundle":"https://pith.science/.well-known/pith/4LEDQXAON64BZ5UITZT2VJGUV3/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:4LEDQXAON64BZ5UITZT2VJGUV3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a4628f830d8697a3c74d176da770d3838c7384fe860b0feeb384229ff66fa407","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-10-06T14:53:20Z","title_canon_sha256":"9726524f5e99c11ec42d23cb59c2658e1acfd0ac72631367b33a1007b7df5289"},"schema_version":"1.0","source":{"id":"1710.02436","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1710.02436","created_at":"2026-05-18T00:33:33Z"},{"alias_kind":"arxiv_version","alias_value":"1710.02436v1","created_at":"2026-05-18T00:33:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1710.02436","created_at":"2026-05-18T00:33:33Z"},{"alias_kind":"pith_short_12","alias_value":"4LEDQXAON64B","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_16","alias_value":"4LEDQXAON64BZ5UI","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_8","alias_value":"4LEDQXAO","created_at":"2026-05-18T12:31:00Z"}],"graph_snapshots":[{"event_id":"sha256:6cc0c2984cfe1437b226233906242d7ac9102e2f2d282b54fa2f920795acf433","target":"graph","created_at":"2026-05-18T00:33:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Natural protein molecules are exceptional polymers. Encoded in apparently random strings of amino-acids, these objects perform clear physical tasks that are rare to find by simple chance. Accurate folding, specific binding, powerful catalysis, are examples of basic chemical activities that the great majority of polypeptides do not display, and are thought to be the outcome of the natural history of proteins. Function, a concept genuine to Biology, is at the core of evolution and often conflicts with the physical constraints. Locating the frustration between discrepant goals in a recurrent syst","authors_text":"Diego U. Ferreiro, Elizabeth A. Komives, Peter G. Wolynes","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-10-06T14:53:20Z","title":"Frustration, function and folding"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1710.02436","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:564bd3ab0ab1caed00ea2bdbb634e1b4dbac172991a8c9075be726f358d31885","target":"record","created_at":"2026-05-18T00:33:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a4628f830d8697a3c74d176da770d3838c7384fe860b0feeb384229ff66fa407","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2017-10-06T14:53:20Z","title_canon_sha256":"9726524f5e99c11ec42d23cb59c2658e1acfd0ac72631367b33a1007b7df5289"},"schema_version":"1.0","source":{"id":"1710.02436","kind":"arxiv","version":1}},"canonical_sha256":"e2c8385c0e6fb81cf6889e67aaa4d4aec85380980fdf7f5245d1a24895fc3e4b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e2c8385c0e6fb81cf6889e67aaa4d4aec85380980fdf7f5245d1a24895fc3e4b","first_computed_at":"2026-05-18T00:33:33.420699Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:33:33.420699Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"U/s2/tLXtRFRYFdSaqvygXOhKwplXEdSbr9qXDLrxqK6gPyoE58nWXLKlETBmy2lmMj6pONUJ/U3/ao2xwGMAw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:33:33.421268Z","signed_message":"canonical_sha256_bytes"},"source_id":"1710.02436","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:564bd3ab0ab1caed00ea2bdbb634e1b4dbac172991a8c9075be726f358d31885","sha256:6cc0c2984cfe1437b226233906242d7ac9102e2f2d282b54fa2f920795acf433"],"state_sha256":"4a088e83f4b17be0b16689e1306f6ca5883c64ee76144c0f98921d84f3760086"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"8iFdNw3lUWzUpfZ4n6Y1fhwL7do47DiNHSOY3KpNasTBCCSGjrpRFFf88o4cUTyMRXZsOIK4uxQdYoaFZ2sFCg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-26T15:22:43.081022Z","bundle_sha256":"3559d07f33858dff78b70db9a75bf33aab83f1060f1d76a711aac6af3b3ffa4b"}}