{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:4LRLWWFL3DFP5BBIBQWISZUX4F","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b4e48841bc7f12e260cba7b2e777d28129eaf881fd66695bd34e32aa4831a406","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2025-05-30T17:51:29Z","title_canon_sha256":"9041fa390528f2f955e9eafe7c2c002891092da79caa2581684a544fd9fdbc5a"},"schema_version":"1.0","source":{"id":"2505.24855","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.24855","created_at":"2026-07-05T11:12:57Z"},{"alias_kind":"arxiv_version","alias_value":"2505.24855v1","created_at":"2026-07-05T11:12:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.24855","created_at":"2026-07-05T11:12:57Z"},{"alias_kind":"pith_short_12","alias_value":"4LRLWWFL3DFP","created_at":"2026-07-05T11:12:57Z"},{"alias_kind":"pith_short_16","alias_value":"4LRLWWFL3DFP5BBI","created_at":"2026-07-05T11:12:57Z"},{"alias_kind":"pith_short_8","alias_value":"4LRLWWFL","created_at":"2026-07-05T11:12:57Z"}],"graph_snapshots":[{"event_id":"sha256:efb5d4bfde0cd57a6f3a32e4ba28f4f97223b4928000772cae9f1365d67f7b3a","target":"graph","created_at":"2026-07-05T11:12:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2505.24855/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Understanding the link between structure and function in proteins is fundamental in molecular biology and proteomics. A central question in this context is whether allostery - where the binding of a molecule at one site affects the activity of a distant site - emerges as a further manifestation of the intricate interplay between structure, function, and intrinsic dynamics. This study explores how allosteric regulation is modified when intrinsic protein dynamics operate under out-of-equilibrium conditions. To this purpose, we introduce a simple nonequilibrium model of protein dynamics, inspired","authors_text":"Fabio Cecconi, Giulio Costantini, Lorenzo Caprini, Umberto Marini Bettolo Marconi","cross_cats":["cond-mat.soft"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2025-05-30T17:51:29Z","title":"Active Gaussian Network Model: a non-equilibrium description of protein fluctuations and allosteric behavior"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.24855","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6316e352f9efbd512f3001789c5f8f94eaf285100f5bb87649a78303afbb536c","target":"record","created_at":"2026-07-05T11:12:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b4e48841bc7f12e260cba7b2e777d28129eaf881fd66695bd34e32aa4831a406","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2025-05-30T17:51:29Z","title_canon_sha256":"9041fa390528f2f955e9eafe7c2c002891092da79caa2581684a544fd9fdbc5a"},"schema_version":"1.0","source":{"id":"2505.24855","kind":"arxiv","version":1}},"canonical_sha256":"e2e2bb58abd8cafe84280c2c896697e1666f0ac5390e4267476b339c7c0164aa","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e2e2bb58abd8cafe84280c2c896697e1666f0ac5390e4267476b339c7c0164aa","first_computed_at":"2026-07-05T11:12:57.858962Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:12:57.858962Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"CrRPjls2DrKBH42bI0rypxy/hd3Xz5GFXOZyqMeifyVq3T/Fi/iCPqgWaeYCFcsfuJxXvMWS/33L1tnjOAjZAA==","signature_status":"signed_v1","signed_at":"2026-07-05T11:12:57.859510Z","signed_message":"canonical_sha256_bytes"},"source_id":"2505.24855","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6316e352f9efbd512f3001789c5f8f94eaf285100f5bb87649a78303afbb536c","sha256:efb5d4bfde0cd57a6f3a32e4ba28f4f97223b4928000772cae9f1365d67f7b3a"],"state_sha256":"e84e0eccb30f0eec691ac9479b469a81c0caefca802038d78b50937457422d2a"}