{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:4OAJVD5WOFU7TFRCMUENETZI5L","short_pith_number":"pith:4OAJVD5W","canonical_record":{"source":{"id":"1903.06540","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-03-15T13:24:12Z","cross_cats_sorted":["stat.ME"],"title_canon_sha256":"44596331369e67e6e8d9e004c331fca8b7fbaed7f4d301665a084443485aaa71","abstract_canon_sha256":"044864736f1c124bba4638e51b5625e061f106e3d16905a033567b54b96860de"},"schema_version":"1.0"},"canonical_sha256":"e3809a8fb67169f996226508d24f28eae60382ea0c13455eed6a2bc4bc7bb971","source":{"kind":"arxiv","id":"1903.06540","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1903.06540","created_at":"2026-05-17T23:51:10Z"},{"alias_kind":"arxiv_version","alias_value":"1903.06540v1","created_at":"2026-05-17T23:51:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1903.06540","created_at":"2026-05-17T23:51:10Z"},{"alias_kind":"pith_short_12","alias_value":"4OAJVD5WOFU7","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_16","alias_value":"4OAJVD5WOFU7TFRC","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_8","alias_value":"4OAJVD5W","created_at":"2026-05-18T12:33:10Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:4OAJVD5WOFU7TFRCMUENETZI5L","target":"record","payload":{"canonical_record":{"source":{"id":"1903.06540","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-03-15T13:24:12Z","cross_cats_sorted":["stat.ME"],"title_canon_sha256":"44596331369e67e6e8d9e004c331fca8b7fbaed7f4d301665a084443485aaa71","abstract_canon_sha256":"044864736f1c124bba4638e51b5625e061f106e3d16905a033567b54b96860de"},"schema_version":"1.0"},"canonical_sha256":"e3809a8fb67169f996226508d24f28eae60382ea0c13455eed6a2bc4bc7bb971","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:51:10.526034Z","signature_b64":"+GUfpjnX2CRmoM+WDRwiQ0gmq+JgQD9f0J9YmaWMUD1LjzAodg8TMHqQPWJH3GxhWRAjs4WEqIPB+6ZFqFi6Cw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"e3809a8fb67169f996226508d24f28eae60382ea0c13455eed6a2bc4bc7bb971","last_reissued_at":"2026-05-17T23:51:10.525300Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:51:10.525300Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1903.06540","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:51:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Far8JgwXKiMmOpYkArDqhXXKxWffuPsNnqMleVDIv44pSkHJlAvTej/AM7UYwkk5AwOcJpYlBPdj35WdXDmzBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T18:24:45.212838Z"},"content_sha256":"da85f7ada6c0f4e7e6c60d464dfceebce3c234ba30b35c70ee54e5b451425451","schema_version":"1.0","event_id":"sha256:da85f7ada6c0f4e7e6c60d464dfceebce3c234ba30b35c70ee54e5b451425451"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:4OAJVD5WOFU7TFRCMUENETZI5L","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Linear system identification from ensemble snapshot observations","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.ME"],"primary_cat":"q-bio.QM","authors_text":"Atte Aalto, Jorge Goncalves","submitted_at":"2019-03-15T13:24:12Z","abstract_excerpt":"Developments in transcriptomics techniques have caused a large demand in tailored computational methods for modelling gene expression dynamics from experimental data. Recently, so-called single-cell experiments have revolutionised genetic studies. These experiments yield gene expression data in single cell resolution for a large number of cells at a time. However, the cells are destroyed in the measurement process, and so the data consist of snapshots of an ensemble evolving over time, instead of time series. The problem studied in this article is how such data can be used in modelling gene re"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1903.06540","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:51:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JZNTG7MpYH9wCRczGsQZGaufpZI5Qi9AVW0VtpFoXjme4qIeTF1lUvvrCiMnGMU0X6vqkqL081lii+uv2EItAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T18:24:45.213188Z"},"content_sha256":"894b9224f972dd27e02e2661c89a8d5705a357d5b8addbf636b6895ad0191ed2","schema_version":"1.0","event_id":"sha256:894b9224f972dd27e02e2661c89a8d5705a357d5b8addbf636b6895ad0191ed2"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/4OAJVD5WOFU7TFRCMUENETZI5L/bundle.json","state_url":"https://pith.science/pith/4OAJVD5WOFU7TFRCMUENETZI5L/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/4OAJVD5WOFU7TFRCMUENETZI5L/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-02T18:24:45Z","links":{"resolver":"https://pith.science/pith/4OAJVD5WOFU7TFRCMUENETZI5L","bundle":"https://pith.science/pith/4OAJVD5WOFU7TFRCMUENETZI5L/bundle.json","state":"https://pith.science/pith/4OAJVD5WOFU7TFRCMUENETZI5L/state.json","well_known_bundle":"https://pith.science/.well-known/pith/4OAJVD5WOFU7TFRCMUENETZI5L/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:4OAJVD5WOFU7TFRCMUENETZI5L","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"044864736f1c124bba4638e51b5625e061f106e3d16905a033567b54b96860de","cross_cats_sorted":["stat.ME"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-03-15T13:24:12Z","title_canon_sha256":"44596331369e67e6e8d9e004c331fca8b7fbaed7f4d301665a084443485aaa71"},"schema_version":"1.0","source":{"id":"1903.06540","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1903.06540","created_at":"2026-05-17T23:51:10Z"},{"alias_kind":"arxiv_version","alias_value":"1903.06540v1","created_at":"2026-05-17T23:51:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1903.06540","created_at":"2026-05-17T23:51:10Z"},{"alias_kind":"pith_short_12","alias_value":"4OAJVD5WOFU7","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_16","alias_value":"4OAJVD5WOFU7TFRC","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_8","alias_value":"4OAJVD5W","created_at":"2026-05-18T12:33:10Z"}],"graph_snapshots":[{"event_id":"sha256:894b9224f972dd27e02e2661c89a8d5705a357d5b8addbf636b6895ad0191ed2","target":"graph","created_at":"2026-05-17T23:51:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Developments in transcriptomics techniques have caused a large demand in tailored computational methods for modelling gene expression dynamics from experimental data. Recently, so-called single-cell experiments have revolutionised genetic studies. These experiments yield gene expression data in single cell resolution for a large number of cells at a time. However, the cells are destroyed in the measurement process, and so the data consist of snapshots of an ensemble evolving over time, instead of time series. The problem studied in this article is how such data can be used in modelling gene re","authors_text":"Atte Aalto, Jorge Goncalves","cross_cats":["stat.ME"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-03-15T13:24:12Z","title":"Linear system identification from ensemble snapshot observations"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1903.06540","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:da85f7ada6c0f4e7e6c60d464dfceebce3c234ba30b35c70ee54e5b451425451","target":"record","created_at":"2026-05-17T23:51:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"044864736f1c124bba4638e51b5625e061f106e3d16905a033567b54b96860de","cross_cats_sorted":["stat.ME"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-03-15T13:24:12Z","title_canon_sha256":"44596331369e67e6e8d9e004c331fca8b7fbaed7f4d301665a084443485aaa71"},"schema_version":"1.0","source":{"id":"1903.06540","kind":"arxiv","version":1}},"canonical_sha256":"e3809a8fb67169f996226508d24f28eae60382ea0c13455eed6a2bc4bc7bb971","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e3809a8fb67169f996226508d24f28eae60382ea0c13455eed6a2bc4bc7bb971","first_computed_at":"2026-05-17T23:51:10.525300Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:51:10.525300Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"+GUfpjnX2CRmoM+WDRwiQ0gmq+JgQD9f0J9YmaWMUD1LjzAodg8TMHqQPWJH3GxhWRAjs4WEqIPB+6ZFqFi6Cw==","signature_status":"signed_v1","signed_at":"2026-05-17T23:51:10.526034Z","signed_message":"canonical_sha256_bytes"},"source_id":"1903.06540","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:da85f7ada6c0f4e7e6c60d464dfceebce3c234ba30b35c70ee54e5b451425451","sha256:894b9224f972dd27e02e2661c89a8d5705a357d5b8addbf636b6895ad0191ed2"],"state_sha256":"b938827c02e3853933cf56571a72c2244ac5e2ab38e720453ff1c6271e8bdb2c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"L3hpo8++Hz4lTtmnrJ0E5pZ6CwexjoOa5MvKHV38RPUbwd8Oh1/L+KwqAh5z3kRIlk5Bm1/Z5jZlAtrqAm18CA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-02T18:24:45.215118Z","bundle_sha256":"3cb1f5c500922d75890654ef1420dc7d1f258ed4e06d685580d72f3f26bdf16f"}}