{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:4R6VCVAHJXKVNRHXRRFSG7HZLY","short_pith_number":"pith:4R6VCVAH","canonical_record":{"source":{"id":"1606.01802","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-06-06T16:00:54Z","cross_cats_sorted":[],"title_canon_sha256":"50fb8dbf24e4d25cefaef4809bd732653c7b7ff1f799c4d8bf7cc1df9d564a78","abstract_canon_sha256":"b461158ca50943a2026c627b30f6b78a009d5324ea78f6ea742c54480c97fe1e"},"schema_version":"1.0"},"canonical_sha256":"e47d5154074dd556c4f78c4b237cf95e0cfe98c4557e5feb112f4ecf78e7557f","source":{"kind":"arxiv","id":"1606.01802","version":4},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1606.01802","created_at":"2026-05-18T01:01:08Z"},{"alias_kind":"arxiv_version","alias_value":"1606.01802v4","created_at":"2026-05-18T01:01:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1606.01802","created_at":"2026-05-18T01:01:08Z"},{"alias_kind":"pith_short_12","alias_value":"4R6VCVAHJXKV","created_at":"2026-05-18T12:29:58Z"},{"alias_kind":"pith_short_16","alias_value":"4R6VCVAHJXKVNRHX","created_at":"2026-05-18T12:29:58Z"},{"alias_kind":"pith_short_8","alias_value":"4R6VCVAH","created_at":"2026-05-18T12:29:58Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:4R6VCVAHJXKVNRHXRRFSG7HZLY","target":"record","payload":{"canonical_record":{"source":{"id":"1606.01802","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-06-06T16:00:54Z","cross_cats_sorted":[],"title_canon_sha256":"50fb8dbf24e4d25cefaef4809bd732653c7b7ff1f799c4d8bf7cc1df9d564a78","abstract_canon_sha256":"b461158ca50943a2026c627b30f6b78a009d5324ea78f6ea742c54480c97fe1e"},"schema_version":"1.0"},"canonical_sha256":"e47d5154074dd556c4f78c4b237cf95e0cfe98c4557e5feb112f4ecf78e7557f","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:01:08.392278Z","signature_b64":"j9aAX7GsNrPvySDnm4IJkaJbkERbXEpqjAt2X0uDkgbicuQiGDI/2d3JEomHmVqSw5x0UF0oeaikk0LpDKqkDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"e47d5154074dd556c4f78c4b237cf95e0cfe98c4557e5feb112f4ecf78e7557f","last_reissued_at":"2026-05-18T01:01:08.390810Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:01:08.390810Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1606.01802","source_version":4,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:01:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"17MW7sUj2Cuv3izR0SV5acPUD0oqsGiVZLHx4u//Z2qn8ziIKjDU22wNtAX7SWTNfbfPG2WLP8B7jKPqS1A0Ag==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T11:32:03.403955Z"},"content_sha256":"4e7bfad9ad59b816147218de38c6e6296f1272875fb9a58fc25a26320038b7b2","schema_version":"1.0","event_id":"sha256:4e7bfad9ad59b816147218de38c6e6296f1272875fb9a58fc25a26320038b7b2"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:4R6VCVAHJXKVNRHXRRFSG7HZLY","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Image-Based Modeling of Blood Flow and Oxygen Transfer in Feto-Placental Capillaries","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.TO","authors_text":"Igor L. Chernyavsky, Jiri Janacek, Lucie Kubinova, Marie Jirkovska, Oliver E. Jensen, Paul Brownbill, Philip Pearce","submitted_at":"2016-06-06T16:00:54Z","abstract_excerpt":"During pregnancy, oxygen diffuses from maternal to fetal blood through villous trees in the placenta. In this paper, we simulate blood flow and oxygen transfer in feto-placental capillaries by converting three-dimensional representations of villous and capillary surfaces, reconstructed from confocal laser scanning microscopy, to finite-element meshes, and calculating values of vascular flow resistance and total oxygen transfer. The relationship between the total oxygen transfer rate and the pressure drop through the capillary is shown to be captured across a wide range of pressure drops by phy"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1606.01802","kind":"arxiv","version":4},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:01:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"vXuy0UQk61iGMlYMcktD3cSb6ivM51AA3HnKh30UvzP703rCU2diYgoYVzstE/3v6nsi13Nf7vdufZH3x5YsAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T11:32:03.404297Z"},"content_sha256":"f630a7a966cd565064050071f94b94d0f0afd6244c1dd0614a4f88a68284347a","schema_version":"1.0","event_id":"sha256:f630a7a966cd565064050071f94b94d0f0afd6244c1dd0614a4f88a68284347a"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/4R6VCVAHJXKVNRHXRRFSG7HZLY/bundle.json","state_url":"https://pith.science/pith/4R6VCVAHJXKVNRHXRRFSG7HZLY/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/4R6VCVAHJXKVNRHXRRFSG7HZLY/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-04T11:32:03Z","links":{"resolver":"https://pith.science/pith/4R6VCVAHJXKVNRHXRRFSG7HZLY","bundle":"https://pith.science/pith/4R6VCVAHJXKVNRHXRRFSG7HZLY/bundle.json","state":"https://pith.science/pith/4R6VCVAHJXKVNRHXRRFSG7HZLY/state.json","well_known_bundle":"https://pith.science/.well-known/pith/4R6VCVAHJXKVNRHXRRFSG7HZLY/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:4R6VCVAHJXKVNRHXRRFSG7HZLY","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b461158ca50943a2026c627b30f6b78a009d5324ea78f6ea742c54480c97fe1e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-06-06T16:00:54Z","title_canon_sha256":"50fb8dbf24e4d25cefaef4809bd732653c7b7ff1f799c4d8bf7cc1df9d564a78"},"schema_version":"1.0","source":{"id":"1606.01802","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1606.01802","created_at":"2026-05-18T01:01:08Z"},{"alias_kind":"arxiv_version","alias_value":"1606.01802v4","created_at":"2026-05-18T01:01:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1606.01802","created_at":"2026-05-18T01:01:08Z"},{"alias_kind":"pith_short_12","alias_value":"4R6VCVAHJXKV","created_at":"2026-05-18T12:29:58Z"},{"alias_kind":"pith_short_16","alias_value":"4R6VCVAHJXKVNRHX","created_at":"2026-05-18T12:29:58Z"},{"alias_kind":"pith_short_8","alias_value":"4R6VCVAH","created_at":"2026-05-18T12:29:58Z"}],"graph_snapshots":[{"event_id":"sha256:f630a7a966cd565064050071f94b94d0f0afd6244c1dd0614a4f88a68284347a","target":"graph","created_at":"2026-05-18T01:01:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"During pregnancy, oxygen diffuses from maternal to fetal blood through villous trees in the placenta. In this paper, we simulate blood flow and oxygen transfer in feto-placental capillaries by converting three-dimensional representations of villous and capillary surfaces, reconstructed from confocal laser scanning microscopy, to finite-element meshes, and calculating values of vascular flow resistance and total oxygen transfer. The relationship between the total oxygen transfer rate and the pressure drop through the capillary is shown to be captured across a wide range of pressure drops by phy","authors_text":"Igor L. Chernyavsky, Jiri Janacek, Lucie Kubinova, Marie Jirkovska, Oliver E. Jensen, Paul Brownbill, Philip Pearce","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-06-06T16:00:54Z","title":"Image-Based Modeling of Blood Flow and Oxygen Transfer in Feto-Placental Capillaries"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1606.01802","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4e7bfad9ad59b816147218de38c6e6296f1272875fb9a58fc25a26320038b7b2","target":"record","created_at":"2026-05-18T01:01:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b461158ca50943a2026c627b30f6b78a009d5324ea78f6ea742c54480c97fe1e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-06-06T16:00:54Z","title_canon_sha256":"50fb8dbf24e4d25cefaef4809bd732653c7b7ff1f799c4d8bf7cc1df9d564a78"},"schema_version":"1.0","source":{"id":"1606.01802","kind":"arxiv","version":4}},"canonical_sha256":"e47d5154074dd556c4f78c4b237cf95e0cfe98c4557e5feb112f4ecf78e7557f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e47d5154074dd556c4f78c4b237cf95e0cfe98c4557e5feb112f4ecf78e7557f","first_computed_at":"2026-05-18T01:01:08.390810Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:01:08.390810Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"j9aAX7GsNrPvySDnm4IJkaJbkERbXEpqjAt2X0uDkgbicuQiGDI/2d3JEomHmVqSw5x0UF0oeaikk0LpDKqkDg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:01:08.392278Z","signed_message":"canonical_sha256_bytes"},"source_id":"1606.01802","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4e7bfad9ad59b816147218de38c6e6296f1272875fb9a58fc25a26320038b7b2","sha256:f630a7a966cd565064050071f94b94d0f0afd6244c1dd0614a4f88a68284347a"],"state_sha256":"57cd9930c7d4155331142e29370d49f74c77e1986fd60e3a2e460b9c654617cb"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"nZVkxO2JanxVrDiiLWgG1pKx0d+1TK9I1Pk5hZAaNUEoy7IlvUkY5Xu+eArO35+24o0EEWGDsGr7yu79bY//Cg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-04T11:32:03.406332Z","bundle_sha256":"55a5818bc73f3f9618d54f4cae7903351c6dc4307606390369fbeec8617dd3e8"}}