{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:4ULOQTXLLTXV7XWMJKGJ2STZ6Q","short_pith_number":"pith:4ULOQTXL","canonical_record":{"source":{"id":"1910.12267","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2019-10-27T14:23:16Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"6b5be4e032320ca0f6e0cbd91ceee713e7cfa012d7c386ae6dd5be7699770e1c","abstract_canon_sha256":"eb08e9b8665d6e7176ed81bd9c71502398a0ca16d53d894baa838564de090138"},"schema_version":"1.0"},"canonical_sha256":"e516e84eeb5cef5fdecc4a8c9d4a79f411c5e87f402eb24983b1a774c8012b23","source":{"kind":"arxiv","id":"1910.12267","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1910.12267","created_at":"2026-07-05T00:15:15Z"},{"alias_kind":"arxiv_version","alias_value":"1910.12267v1","created_at":"2026-07-05T00:15:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1910.12267","created_at":"2026-07-05T00:15:15Z"},{"alias_kind":"pith_short_12","alias_value":"4ULOQTXLLTXV","created_at":"2026-07-05T00:15:15Z"},{"alias_kind":"pith_short_16","alias_value":"4ULOQTXLLTXV7XWM","created_at":"2026-07-05T00:15:15Z"},{"alias_kind":"pith_short_8","alias_value":"4ULOQTXL","created_at":"2026-07-05T00:15:15Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:4ULOQTXLLTXV7XWMJKGJ2STZ6Q","target":"record","payload":{"canonical_record":{"source":{"id":"1910.12267","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2019-10-27T14:23:16Z","cross_cats_sorted":["stat.AP"],"title_canon_sha256":"6b5be4e032320ca0f6e0cbd91ceee713e7cfa012d7c386ae6dd5be7699770e1c","abstract_canon_sha256":"eb08e9b8665d6e7176ed81bd9c71502398a0ca16d53d894baa838564de090138"},"schema_version":"1.0"},"canonical_sha256":"e516e84eeb5cef5fdecc4a8c9d4a79f411c5e87f402eb24983b1a774c8012b23","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T00:15:15.059972Z","signature_b64":"XZQXlOe4NiA891p9q8dHyzU9mPuyjwPMRpqAFfe21AW32/coIPzcDRsC9oKPtloIF7rTmplkrZFHMDRad5QIBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"e516e84eeb5cef5fdecc4a8c9d4a79f411c5e87f402eb24983b1a774c8012b23","last_reissued_at":"2026-07-05T00:15:15.059630Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T00:15:15.059630Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1910.12267","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T00:15:15Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"s6saIvi5uc38zCYOXrpt21ZdCJduTUUA4A2OUhqkl06XAZ6n/DOBc3ZGG0FffacQZn9pzWVVO+UIF8tlsODTBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-23T22:06:40.075126Z"},"content_sha256":"1a431a08fa0571b02f85c791dc715a377ef32f3544c99a91f3fecd42aca30454","schema_version":"1.0","event_id":"sha256:1a431a08fa0571b02f85c791dc715a377ef32f3544c99a91f3fecd42aca30454"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:4ULOQTXLLTXV7XWMJKGJ2STZ6Q","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A novel high-power test for continuous outcomes truncated by death","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.AP"],"primary_cat":"stat.ME","authors_text":"Andreas Kryger Jensen, Theis Lange","submitted_at":"2019-10-27T14:23:16Z","abstract_excerpt":"Patient reported outcomes including quality of life (QoL) assessments are increasingly being included as either primary or secondary outcomes in randomized controlled trials. While making the outcomes more relevant for patients it entails a challenge in cases where death or a similar event makes the outcome of interest undefined. A pragmatic - and much used - solution is to assign diseased patient with the lowest possible QoL score. This makes medical sense, but creates a statistical problem since traditional tests such as t-tests or Wilcox tests potentially looses large amounts of statistical"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1910.12267","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/1910.12267/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T00:15:15Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9ptL+FhKWunk5wXFjRf7UVL7npZH02oGwp3xShEMlHIYuYxmyW+g6/VlrBgs1pnmnlYum//KFStlKilP4QuLBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-23T22:06:40.075523Z"},"content_sha256":"891ab1295ef2cf742d2af7dddc789e88b26341eddda94ca84e86adc9bf0f5395","schema_version":"1.0","event_id":"sha256:891ab1295ef2cf742d2af7dddc789e88b26341eddda94ca84e86adc9bf0f5395"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/4ULOQTXLLTXV7XWMJKGJ2STZ6Q/bundle.json","state_url":"https://pith.science/pith/4ULOQTXLLTXV7XWMJKGJ2STZ6Q/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/4ULOQTXLLTXV7XWMJKGJ2STZ6Q/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-23T22:06:40Z","links":{"resolver":"https://pith.science/pith/4ULOQTXLLTXV7XWMJKGJ2STZ6Q","bundle":"https://pith.science/pith/4ULOQTXLLTXV7XWMJKGJ2STZ6Q/bundle.json","state":"https://pith.science/pith/4ULOQTXLLTXV7XWMJKGJ2STZ6Q/state.json","well_known_bundle":"https://pith.science/.well-known/pith/4ULOQTXLLTXV7XWMJKGJ2STZ6Q/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:4ULOQTXLLTXV7XWMJKGJ2STZ6Q","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"eb08e9b8665d6e7176ed81bd9c71502398a0ca16d53d894baa838564de090138","cross_cats_sorted":["stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2019-10-27T14:23:16Z","title_canon_sha256":"6b5be4e032320ca0f6e0cbd91ceee713e7cfa012d7c386ae6dd5be7699770e1c"},"schema_version":"1.0","source":{"id":"1910.12267","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1910.12267","created_at":"2026-07-05T00:15:15Z"},{"alias_kind":"arxiv_version","alias_value":"1910.12267v1","created_at":"2026-07-05T00:15:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1910.12267","created_at":"2026-07-05T00:15:15Z"},{"alias_kind":"pith_short_12","alias_value":"4ULOQTXLLTXV","created_at":"2026-07-05T00:15:15Z"},{"alias_kind":"pith_short_16","alias_value":"4ULOQTXLLTXV7XWM","created_at":"2026-07-05T00:15:15Z"},{"alias_kind":"pith_short_8","alias_value":"4ULOQTXL","created_at":"2026-07-05T00:15:15Z"}],"graph_snapshots":[{"event_id":"sha256:891ab1295ef2cf742d2af7dddc789e88b26341eddda94ca84e86adc9bf0f5395","target":"graph","created_at":"2026-07-05T00:15:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/1910.12267/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Patient reported outcomes including quality of life (QoL) assessments are increasingly being included as either primary or secondary outcomes in randomized controlled trials. While making the outcomes more relevant for patients it entails a challenge in cases where death or a similar event makes the outcome of interest undefined. A pragmatic - and much used - solution is to assign diseased patient with the lowest possible QoL score. This makes medical sense, but creates a statistical problem since traditional tests such as t-tests or Wilcox tests potentially looses large amounts of statistical","authors_text":"Andreas Kryger Jensen, Theis Lange","cross_cats":["stat.AP"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2019-10-27T14:23:16Z","title":"A novel high-power test for continuous outcomes truncated by death"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1910.12267","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1a431a08fa0571b02f85c791dc715a377ef32f3544c99a91f3fecd42aca30454","target":"record","created_at":"2026-07-05T00:15:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"eb08e9b8665d6e7176ed81bd9c71502398a0ca16d53d894baa838564de090138","cross_cats_sorted":["stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2019-10-27T14:23:16Z","title_canon_sha256":"6b5be4e032320ca0f6e0cbd91ceee713e7cfa012d7c386ae6dd5be7699770e1c"},"schema_version":"1.0","source":{"id":"1910.12267","kind":"arxiv","version":1}},"canonical_sha256":"e516e84eeb5cef5fdecc4a8c9d4a79f411c5e87f402eb24983b1a774c8012b23","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e516e84eeb5cef5fdecc4a8c9d4a79f411c5e87f402eb24983b1a774c8012b23","first_computed_at":"2026-07-05T00:15:15.059630Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T00:15:15.059630Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"XZQXlOe4NiA891p9q8dHyzU9mPuyjwPMRpqAFfe21AW32/coIPzcDRsC9oKPtloIF7rTmplkrZFHMDRad5QIBQ==","signature_status":"signed_v1","signed_at":"2026-07-05T00:15:15.059972Z","signed_message":"canonical_sha256_bytes"},"source_id":"1910.12267","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1a431a08fa0571b02f85c791dc715a377ef32f3544c99a91f3fecd42aca30454","sha256:891ab1295ef2cf742d2af7dddc789e88b26341eddda94ca84e86adc9bf0f5395"],"state_sha256":"295e9cb59fbf99d10b1c977e3dbfc0f7c5de86bab48a9a457e9b7de8d1f4e770"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2yLu2ZAvBTqSyOB4LINWtitn/x3ESkwmXecPuZxxR6XL6t0ZmEXudYBzOOX1HomfXJrnReTnyHIGJ6nlyG66DQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-23T22:06:40.078205Z","bundle_sha256":"3a4e5291326a24fa044f0a4d8a2ac51c6114d56cb1c81aeed73cfb33b6d8ac42"}}