{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:52WP6DMILZC6WRS2GSR662DMAQ","short_pith_number":"pith:52WP6DMI","schema_version":"1.0","canonical_sha256":"eeacff0d885e45eb465a34a3ef686c041c92fbd473ee56ac52a8295a43354457","source":{"kind":"arxiv","id":"1603.06372","version":1},"attestation_state":"computed","paper":{"title":"Evaluating the Impact of Treating the Optimal Subgroup","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Alexander R. Luedtke, Mark J. van der Laan","submitted_at":"2016-03-21T10:08:20Z","abstract_excerpt":"Suppose we have a binary treatment used to influence an outcome. Given data from an observational or controlled study, we wish to determine whether or not there exists some subset of observed covariates in which the treatment is more effective than the standard practice of no treatment. Furthermore, we wish to quantify the improvement in population mean outcome that will be seen if this subgroup receives treatment and the rest of the population remains untreated. We show that this problem is surprisingly challenging given how often it is an (at least implicit) study objective. Blindly applying"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1603.06372","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-03-21T10:08:20Z","cross_cats_sorted":[],"title_canon_sha256":"5847d9c568133bd86acaddb5b03f0b113b3faa16ae2be3e4ee68ec649aeaf9a3","abstract_canon_sha256":"1f9f2cd89c9ccf130d9b065d80f5cc0ea922e1f66e3a5ce40d6605e3dc43b675"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:18:48.658811Z","signature_b64":"wEQuNc9Y+E95R/4V79Fy6mJqYWvfkQm42QGYmEEu2ERPyEcRi+V5fnKGehwKb7y2Az2BEfgpoDZ11jahUEj2Aw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"eeacff0d885e45eb465a34a3ef686c041c92fbd473ee56ac52a8295a43354457","last_reissued_at":"2026-05-18T01:18:48.658214Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:18:48.658214Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Evaluating the Impact of Treating the Optimal Subgroup","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Alexander R. Luedtke, Mark J. van der Laan","submitted_at":"2016-03-21T10:08:20Z","abstract_excerpt":"Suppose we have a binary treatment used to influence an outcome. Given data from an observational or controlled study, we wish to determine whether or not there exists some subset of observed covariates in which the treatment is more effective than the standard practice of no treatment. Furthermore, we wish to quantify the improvement in population mean outcome that will be seen if this subgroup receives treatment and the rest of the population remains untreated. We show that this problem is surprisingly challenging given how often it is an (at least implicit) study objective. Blindly applying"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1603.06372","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1603.06372","created_at":"2026-05-18T01:18:48.658331+00:00"},{"alias_kind":"arxiv_version","alias_value":"1603.06372v1","created_at":"2026-05-18T01:18:48.658331+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1603.06372","created_at":"2026-05-18T01:18:48.658331+00:00"},{"alias_kind":"pith_short_12","alias_value":"52WP6DMILZC6","created_at":"2026-05-18T12:29:58.707656+00:00"},{"alias_kind":"pith_short_16","alias_value":"52WP6DMILZC6WRS2","created_at":"2026-05-18T12:29:58.707656+00:00"},{"alias_kind":"pith_short_8","alias_value":"52WP6DMI","created_at":"2026-05-18T12:29:58.707656+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/52WP6DMILZC6WRS2GSR662DMAQ","json":"https://pith.science/pith/52WP6DMILZC6WRS2GSR662DMAQ.json","graph_json":"https://pith.science/api/pith-number/52WP6DMILZC6WRS2GSR662DMAQ/graph.json","events_json":"https://pith.science/api/pith-number/52WP6DMILZC6WRS2GSR662DMAQ/events.json","paper":"https://pith.science/paper/52WP6DMI"},"agent_actions":{"view_html":"https://pith.science/pith/52WP6DMILZC6WRS2GSR662DMAQ","download_json":"https://pith.science/pith/52WP6DMILZC6WRS2GSR662DMAQ.json","view_paper":"https://pith.science/paper/52WP6DMI","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1603.06372&json=true","fetch_graph":"https://pith.science/api/pith-number/52WP6DMILZC6WRS2GSR662DMAQ/graph.json","fetch_events":"https://pith.science/api/pith-number/52WP6DMILZC6WRS2GSR662DMAQ/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/52WP6DMILZC6WRS2GSR662DMAQ/action/timestamp_anchor","attest_storage":"https://pith.science/pith/52WP6DMILZC6WRS2GSR662DMAQ/action/storage_attestation","attest_author":"https://pith.science/pith/52WP6DMILZC6WRS2GSR662DMAQ/action/author_attestation","sign_citation":"https://pith.science/pith/52WP6DMILZC6WRS2GSR662DMAQ/action/citation_signature","submit_replication":"https://pith.science/pith/52WP6DMILZC6WRS2GSR662DMAQ/action/replication_record"}},"created_at":"2026-05-18T01:18:48.658331+00:00","updated_at":"2026-05-18T01:18:48.658331+00:00"}