{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:53DHIQY6G7ILBZIE3JB54FVCTF","short_pith_number":"pith:53DHIQY6","canonical_record":{"source":{"id":"1404.6283","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-04-24T22:35:56Z","cross_cats_sorted":["physics.data-an","stat.ML"],"title_canon_sha256":"6a240dfca41b642ebda0ec34b2185a5c8159e9c3bf8d616c1c16fe07fac6105b","abstract_canon_sha256":"abd08e90a068f2ccd3585ffc9d8851c6814db23f4528147f46c590fb77b3e5a8"},"schema_version":"1.0"},"canonical_sha256":"eec674431e37d0b0e504da43de16a2996cdb42b366cfabf152276cfe3e2cc6ae","source":{"kind":"arxiv","id":"1404.6283","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1404.6283","created_at":"2026-05-18T02:52:57Z"},{"alias_kind":"arxiv_version","alias_value":"1404.6283v1","created_at":"2026-05-18T02:52:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1404.6283","created_at":"2026-05-18T02:52:57Z"},{"alias_kind":"pith_short_12","alias_value":"53DHIQY6G7IL","created_at":"2026-05-18T12:28:14Z"},{"alias_kind":"pith_short_16","alias_value":"53DHIQY6G7ILBZIE","created_at":"2026-05-18T12:28:14Z"},{"alias_kind":"pith_short_8","alias_value":"53DHIQY6","created_at":"2026-05-18T12:28:14Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:53DHIQY6G7ILBZIE3JB54FVCTF","target":"record","payload":{"canonical_record":{"source":{"id":"1404.6283","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-04-24T22:35:56Z","cross_cats_sorted":["physics.data-an","stat.ML"],"title_canon_sha256":"6a240dfca41b642ebda0ec34b2185a5c8159e9c3bf8d616c1c16fe07fac6105b","abstract_canon_sha256":"abd08e90a068f2ccd3585ffc9d8851c6814db23f4528147f46c590fb77b3e5a8"},"schema_version":"1.0"},"canonical_sha256":"eec674431e37d0b0e504da43de16a2996cdb42b366cfabf152276cfe3e2cc6ae","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:52:57.491605Z","signature_b64":"Do7q8iX7k7NuoGkHywMc1IXu3QCay3S8QuMKK5/b359lJOTWTt8HfEbny9HZxNsk0Ncl6P2N9zpWDW7lD9FuCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"eec674431e37d0b0e504da43de16a2996cdb42b366cfabf152276cfe3e2cc6ae","last_reissued_at":"2026-05-18T02:52:57.491031Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:52:57.491031Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1404.6283","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:52:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9bqqI2rDjd9hp9Clzmoxd2kWLUa43A/zJULV7x6csG08vmY1ArLoN8Y1iMzD5ya9JcTjE6Q0ghzhk2UgRDLhBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T06:01:38.248376Z"},"content_sha256":"79c57376f9b70524ca16373b02eb32b971711687006b6a203fd3fb62b3cf6361","schema_version":"1.0","event_id":"sha256:79c57376f9b70524ca16373b02eb32b971711687006b6a203fd3fb62b3cf6361"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:53DHIQY6G7ILBZIE3JB54FVCTF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Automated adaptive inference of coarse-grained dynamical models in systems biology","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.data-an","stat.ML"],"primary_cat":"q-bio.QM","authors_text":"Bryan C. Daniels, Ilya Nemenman","submitted_at":"2014-04-24T22:35:56Z","abstract_excerpt":"Cellular regulatory dynamics is driven by large and intricate networks of interactions at the molecular scale, whose sheer size obfuscates understanding. In light of limited experimental data, many parameters of such dynamics are unknown, and thus models built on the detailed, mechanistic viewpoint overfit and are not predictive. At the other extreme, simple ad hoc models of complex processes often miss defining features of the underlying systems. Here we propose an approach that instead constructs phenomenological, coarse-grained models of network dynamics that automatically adapt their compl"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1404.6283","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:52:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"swCUVSZbQfh4IWf5okRg1NksigUsr7PlI7qqQ8hyYhC1PqNg832c9fFjne1udMkpmhHfpWjsGmt9gtiuMWZFAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T06:01:38.249037Z"},"content_sha256":"917318637a951bba84cd67fd955e611ac9d0ca9b21de21c793924bfac9e37ed7","schema_version":"1.0","event_id":"sha256:917318637a951bba84cd67fd955e611ac9d0ca9b21de21c793924bfac9e37ed7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/53DHIQY6G7ILBZIE3JB54FVCTF/bundle.json","state_url":"https://pith.science/pith/53DHIQY6G7ILBZIE3JB54FVCTF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/53DHIQY6G7ILBZIE3JB54FVCTF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-09T06:01:38Z","links":{"resolver":"https://pith.science/pith/53DHIQY6G7ILBZIE3JB54FVCTF","bundle":"https://pith.science/pith/53DHIQY6G7ILBZIE3JB54FVCTF/bundle.json","state":"https://pith.science/pith/53DHIQY6G7ILBZIE3JB54FVCTF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/53DHIQY6G7ILBZIE3JB54FVCTF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:53DHIQY6G7ILBZIE3JB54FVCTF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"abd08e90a068f2ccd3585ffc9d8851c6814db23f4528147f46c590fb77b3e5a8","cross_cats_sorted":["physics.data-an","stat.ML"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-04-24T22:35:56Z","title_canon_sha256":"6a240dfca41b642ebda0ec34b2185a5c8159e9c3bf8d616c1c16fe07fac6105b"},"schema_version":"1.0","source":{"id":"1404.6283","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1404.6283","created_at":"2026-05-18T02:52:57Z"},{"alias_kind":"arxiv_version","alias_value":"1404.6283v1","created_at":"2026-05-18T02:52:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1404.6283","created_at":"2026-05-18T02:52:57Z"},{"alias_kind":"pith_short_12","alias_value":"53DHIQY6G7IL","created_at":"2026-05-18T12:28:14Z"},{"alias_kind":"pith_short_16","alias_value":"53DHIQY6G7ILBZIE","created_at":"2026-05-18T12:28:14Z"},{"alias_kind":"pith_short_8","alias_value":"53DHIQY6","created_at":"2026-05-18T12:28:14Z"}],"graph_snapshots":[{"event_id":"sha256:917318637a951bba84cd67fd955e611ac9d0ca9b21de21c793924bfac9e37ed7","target":"graph","created_at":"2026-05-18T02:52:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Cellular regulatory dynamics is driven by large and intricate networks of interactions at the molecular scale, whose sheer size obfuscates understanding. In light of limited experimental data, many parameters of such dynamics are unknown, and thus models built on the detailed, mechanistic viewpoint overfit and are not predictive. At the other extreme, simple ad hoc models of complex processes often miss defining features of the underlying systems. Here we propose an approach that instead constructs phenomenological, coarse-grained models of network dynamics that automatically adapt their compl","authors_text":"Bryan C. Daniels, Ilya Nemenman","cross_cats":["physics.data-an","stat.ML"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-04-24T22:35:56Z","title":"Automated adaptive inference of coarse-grained dynamical models in systems biology"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1404.6283","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:79c57376f9b70524ca16373b02eb32b971711687006b6a203fd3fb62b3cf6361","target":"record","created_at":"2026-05-18T02:52:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"abd08e90a068f2ccd3585ffc9d8851c6814db23f4528147f46c590fb77b3e5a8","cross_cats_sorted":["physics.data-an","stat.ML"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2014-04-24T22:35:56Z","title_canon_sha256":"6a240dfca41b642ebda0ec34b2185a5c8159e9c3bf8d616c1c16fe07fac6105b"},"schema_version":"1.0","source":{"id":"1404.6283","kind":"arxiv","version":1}},"canonical_sha256":"eec674431e37d0b0e504da43de16a2996cdb42b366cfabf152276cfe3e2cc6ae","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"eec674431e37d0b0e504da43de16a2996cdb42b366cfabf152276cfe3e2cc6ae","first_computed_at":"2026-05-18T02:52:57.491031Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:52:57.491031Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Do7q8iX7k7NuoGkHywMc1IXu3QCay3S8QuMKK5/b359lJOTWTt8HfEbny9HZxNsk0Ncl6P2N9zpWDW7lD9FuCA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:52:57.491605Z","signed_message":"canonical_sha256_bytes"},"source_id":"1404.6283","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:79c57376f9b70524ca16373b02eb32b971711687006b6a203fd3fb62b3cf6361","sha256:917318637a951bba84cd67fd955e611ac9d0ca9b21de21c793924bfac9e37ed7"],"state_sha256":"3a13c36511df5981f44cf4b277e03e3f1d39798e01fe5b2e8adee0e4dde2c16b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"nNb2Hpt7GVzaka9Xqrr6kxYFp4xjqEoULwfscBvSVZUZtYppG3WNfQqeNp40mcUUTMupOC/hcxRMuy0QDwT7Cw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-09T06:01:38.253407Z","bundle_sha256":"3e40909b2e443f5bd1a4ca0fdcf92f889f7caafd52ff0276e3e5adf9bf280901"}}