{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2026:562LEK4UC3H43YXVPSR5OYE3ML","short_pith_number":"pith:562LEK4U","schema_version":"1.0","canonical_sha256":"efb4b22b9416cfcde2f57ca3d7609b62f1830a74b7dcfd78e0f7da7c73ad7e1d","source":{"kind":"arxiv","id":"2606.22677","version":1},"attestation_state":"computed","paper":{"title":"Selectivity in tip-induced skeletal editing via heteroatom substitution","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"cond-mat.mes-hall","authors_text":"Diego Pe\\~na, Florian Albrecht, Henrik Gr\\\"onbeck, Leo Gross, Manuel Vilas-Varela, Rasmus Svensson, Shantanu Mishra, Valentina Malave","submitted_at":"2026-06-21T21:33:37Z","abstract_excerpt":"Skeletal editing enables precise structural modifications of molecules at late stages of a synthetic sequence, with applications in drug discovery and materials science. We recently demonstrated skeletal editing on the single-molecule scale. Voltage pulses applied by the tip of a scanning probe microscope to an oxygen-containing seven-membered heterocycle led to both oxygen deletion and ring-contraction rearrangement reactions. An open question is whether selective skeletal editing of a heterocyclic core can be achieved by an appropriate choice of the heteroatom. Here, we show that tip-induced"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2606.22677","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cond-mat.mes-hall","submitted_at":"2026-06-21T21:33:37Z","cross_cats_sorted":[],"title_canon_sha256":"8d4834ac9b47133e6f7d8c329373c5ddd0fa6396d2ba2f23be416e6d5fc89e91","abstract_canon_sha256":"5a0b8d3e736dddd4b03b0dc85a814fc5891cbf721882adbccd6d35a8673815b7"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-23T02:13:44.610526Z","signature_b64":"1p2IrOHIw0++vaXbiYj8j/mdfy7BMnkEKWm8ggrj6rmxw1veIcri+nSG0nl79rolmdnO1wi6S/zAcxD7XlcRCQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"efb4b22b9416cfcde2f57ca3d7609b62f1830a74b7dcfd78e0f7da7c73ad7e1d","last_reissued_at":"2026-06-23T02:13:44.610114Z","signature_status":"signed_v1","first_computed_at":"2026-06-23T02:13:44.610114Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Selectivity in tip-induced skeletal editing via heteroatom substitution","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"cond-mat.mes-hall","authors_text":"Diego Pe\\~na, Florian Albrecht, Henrik Gr\\\"onbeck, Leo Gross, Manuel Vilas-Varela, Rasmus Svensson, Shantanu Mishra, Valentina Malave","submitted_at":"2026-06-21T21:33:37Z","abstract_excerpt":"Skeletal editing enables precise structural modifications of molecules at late stages of a synthetic sequence, with applications in drug discovery and materials science. We recently demonstrated skeletal editing on the single-molecule scale. Voltage pulses applied by the tip of a scanning probe microscope to an oxygen-containing seven-membered heterocycle led to both oxygen deletion and ring-contraction rearrangement reactions. An open question is whether selective skeletal editing of a heterocyclic core can be achieved by an appropriate choice of the heteroatom. Here, we show that tip-induced"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.22677","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.22677/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2606.22677","created_at":"2026-06-23T02:13:44.610174+00:00"},{"alias_kind":"arxiv_version","alias_value":"2606.22677v1","created_at":"2026-06-23T02:13:44.610174+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.22677","created_at":"2026-06-23T02:13:44.610174+00:00"},{"alias_kind":"pith_short_12","alias_value":"562LEK4UC3H4","created_at":"2026-06-23T02:13:44.610174+00:00"},{"alias_kind":"pith_short_16","alias_value":"562LEK4UC3H43YXV","created_at":"2026-06-23T02:13:44.610174+00:00"},{"alias_kind":"pith_short_8","alias_value":"562LEK4U","created_at":"2026-06-23T02:13:44.610174+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/562LEK4UC3H43YXVPSR5OYE3ML","json":"https://pith.science/pith/562LEK4UC3H43YXVPSR5OYE3ML.json","graph_json":"https://pith.science/api/pith-number/562LEK4UC3H43YXVPSR5OYE3ML/graph.json","events_json":"https://pith.science/api/pith-number/562LEK4UC3H43YXVPSR5OYE3ML/events.json","paper":"https://pith.science/paper/562LEK4U"},"agent_actions":{"view_html":"https://pith.science/pith/562LEK4UC3H43YXVPSR5OYE3ML","download_json":"https://pith.science/pith/562LEK4UC3H43YXVPSR5OYE3ML.json","view_paper":"https://pith.science/paper/562LEK4U","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2606.22677&json=true","fetch_graph":"https://pith.science/api/pith-number/562LEK4UC3H43YXVPSR5OYE3ML/graph.json","fetch_events":"https://pith.science/api/pith-number/562LEK4UC3H43YXVPSR5OYE3ML/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/562LEK4UC3H43YXVPSR5OYE3ML/action/timestamp_anchor","attest_storage":"https://pith.science/pith/562LEK4UC3H43YXVPSR5OYE3ML/action/storage_attestation","attest_author":"https://pith.science/pith/562LEK4UC3H43YXVPSR5OYE3ML/action/author_attestation","sign_citation":"https://pith.science/pith/562LEK4UC3H43YXVPSR5OYE3ML/action/citation_signature","submit_replication":"https://pith.science/pith/562LEK4UC3H43YXVPSR5OYE3ML/action/replication_record"}},"created_at":"2026-06-23T02:13:44.610174+00:00","updated_at":"2026-06-23T02:13:44.610174+00:00"}