{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:5BAKFQTRMYIQQFNZAATHW3LT62","short_pith_number":"pith:5BAKFQTR","canonical_record":{"source":{"id":"1701.03095","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2017-01-11T18:51:54Z","cross_cats_sorted":["stat.AP","stat.CO"],"title_canon_sha256":"62c6a56d3fa80e6f633641f9021969c8223abba67ad46993925c30feb0f911a5","abstract_canon_sha256":"4968b2432b801fc3320e526e9d060247c3ef8b0db908eef0858961457638c1ac"},"schema_version":"1.0"},"canonical_sha256":"e840a2c27166110815b900267b6d73f6817b70b9aa1d0c4c7eab99ee8ae34131","source":{"kind":"arxiv","id":"1701.03095","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1701.03095","created_at":"2026-05-18T00:31:22Z"},{"alias_kind":"arxiv_version","alias_value":"1701.03095v2","created_at":"2026-05-18T00:31:22Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1701.03095","created_at":"2026-05-18T00:31:22Z"},{"alias_kind":"pith_short_12","alias_value":"5BAKFQTRMYIQ","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_16","alias_value":"5BAKFQTRMYIQQFNZ","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_8","alias_value":"5BAKFQTR","created_at":"2026-05-18T12:31:00Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:5BAKFQTRMYIQQFNZAATHW3LT62","target":"record","payload":{"canonical_record":{"source":{"id":"1701.03095","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2017-01-11T18:51:54Z","cross_cats_sorted":["stat.AP","stat.CO"],"title_canon_sha256":"62c6a56d3fa80e6f633641f9021969c8223abba67ad46993925c30feb0f911a5","abstract_canon_sha256":"4968b2432b801fc3320e526e9d060247c3ef8b0db908eef0858961457638c1ac"},"schema_version":"1.0"},"canonical_sha256":"e840a2c27166110815b900267b6d73f6817b70b9aa1d0c4c7eab99ee8ae34131","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:31:22.197308Z","signature_b64":"s+RZilwvdVgRvKljFx4s/kaJHwZKNbDVRRXddlwWV4qWmqhuFBqmGv7fPzumTWq3UhHeN6P7rI87Hjq9FRVsAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"e840a2c27166110815b900267b6d73f6817b70b9aa1d0c4c7eab99ee8ae34131","last_reissued_at":"2026-05-18T00:31:22.196631Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:31:22.196631Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1701.03095","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:31:22Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"BdbLYNfRR8vgyZTdc16wwRQ+PIg3zQ92ySuKHXXz3azYRCdgyt919uU2+870TYsh1orhwhkzODqnsfEDPRPjDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T04:05:53.771656Z"},"content_sha256":"128e9eab72437d943d9cb3178d473f5509a80dfcca9e978b1f7a0dbbac720d85","schema_version":"1.0","event_id":"sha256:128e9eab72437d943d9cb3178d473f5509a80dfcca9e978b1f7a0dbbac720d85"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:5BAKFQTRMYIQQFNZAATHW3LT62","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Bayesian estimation of Differential Transcript Usage from RNA-seq data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.AP","stat.CO"],"primary_cat":"q-bio.GN","authors_text":"Magnus Rattray, Panagiotis Papastamoulis","submitted_at":"2017-01-11T18:51:54Z","abstract_excerpt":"Next generation sequencing allows the identification of genes consisting of differentially expressed transcripts, a term which usually refers to changes in the overall expression level. A specific type of differential expression is differential transcript usage (DTU) and targets changes in the relative within gene expression of a transcript. The contribution of this paper is to: (a) extend the use of cjBitSeq to the DTU context, a previously introduced Bayesian model which is originally designed for identifying changes in overall expression levels and (b) propose a Bayesian version of DRIMSeq,"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1701.03095","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:31:22Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Fgi69y115eQ00pC4UYoy10vGHEFIEZ0TJxJmwrGnei0jCRt3OB7WRkP5xtMRALxeC5ot8HfMPmD6x0VbMBB6Ag==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T04:05:53.771995Z"},"content_sha256":"5bd1a4a8d72103ac02f70a6cf08ad3cd8971fb8e360fda430cf323132ab06b35","schema_version":"1.0","event_id":"sha256:5bd1a4a8d72103ac02f70a6cf08ad3cd8971fb8e360fda430cf323132ab06b35"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/5BAKFQTRMYIQQFNZAATHW3LT62/bundle.json","state_url":"https://pith.science/pith/5BAKFQTRMYIQQFNZAATHW3LT62/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/5BAKFQTRMYIQQFNZAATHW3LT62/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-24T04:05:53Z","links":{"resolver":"https://pith.science/pith/5BAKFQTRMYIQQFNZAATHW3LT62","bundle":"https://pith.science/pith/5BAKFQTRMYIQQFNZAATHW3LT62/bundle.json","state":"https://pith.science/pith/5BAKFQTRMYIQQFNZAATHW3LT62/state.json","well_known_bundle":"https://pith.science/.well-known/pith/5BAKFQTRMYIQQFNZAATHW3LT62/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:5BAKFQTRMYIQQFNZAATHW3LT62","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"4968b2432b801fc3320e526e9d060247c3ef8b0db908eef0858961457638c1ac","cross_cats_sorted":["stat.AP","stat.CO"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2017-01-11T18:51:54Z","title_canon_sha256":"62c6a56d3fa80e6f633641f9021969c8223abba67ad46993925c30feb0f911a5"},"schema_version":"1.0","source":{"id":"1701.03095","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1701.03095","created_at":"2026-05-18T00:31:22Z"},{"alias_kind":"arxiv_version","alias_value":"1701.03095v2","created_at":"2026-05-18T00:31:22Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1701.03095","created_at":"2026-05-18T00:31:22Z"},{"alias_kind":"pith_short_12","alias_value":"5BAKFQTRMYIQ","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_16","alias_value":"5BAKFQTRMYIQQFNZ","created_at":"2026-05-18T12:31:00Z"},{"alias_kind":"pith_short_8","alias_value":"5BAKFQTR","created_at":"2026-05-18T12:31:00Z"}],"graph_snapshots":[{"event_id":"sha256:5bd1a4a8d72103ac02f70a6cf08ad3cd8971fb8e360fda430cf323132ab06b35","target":"graph","created_at":"2026-05-18T00:31:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Next generation sequencing allows the identification of genes consisting of differentially expressed transcripts, a term which usually refers to changes in the overall expression level. A specific type of differential expression is differential transcript usage (DTU) and targets changes in the relative within gene expression of a transcript. The contribution of this paper is to: (a) extend the use of cjBitSeq to the DTU context, a previously introduced Bayesian model which is originally designed for identifying changes in overall expression levels and (b) propose a Bayesian version of DRIMSeq,","authors_text":"Magnus Rattray, Panagiotis Papastamoulis","cross_cats":["stat.AP","stat.CO"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2017-01-11T18:51:54Z","title":"Bayesian estimation of Differential Transcript Usage from RNA-seq data"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1701.03095","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:128e9eab72437d943d9cb3178d473f5509a80dfcca9e978b1f7a0dbbac720d85","target":"record","created_at":"2026-05-18T00:31:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"4968b2432b801fc3320e526e9d060247c3ef8b0db908eef0858961457638c1ac","cross_cats_sorted":["stat.AP","stat.CO"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2017-01-11T18:51:54Z","title_canon_sha256":"62c6a56d3fa80e6f633641f9021969c8223abba67ad46993925c30feb0f911a5"},"schema_version":"1.0","source":{"id":"1701.03095","kind":"arxiv","version":2}},"canonical_sha256":"e840a2c27166110815b900267b6d73f6817b70b9aa1d0c4c7eab99ee8ae34131","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e840a2c27166110815b900267b6d73f6817b70b9aa1d0c4c7eab99ee8ae34131","first_computed_at":"2026-05-18T00:31:22.196631Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:31:22.196631Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"s+RZilwvdVgRvKljFx4s/kaJHwZKNbDVRRXddlwWV4qWmqhuFBqmGv7fPzumTWq3UhHeN6P7rI87Hjq9FRVsAg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:31:22.197308Z","signed_message":"canonical_sha256_bytes"},"source_id":"1701.03095","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:128e9eab72437d943d9cb3178d473f5509a80dfcca9e978b1f7a0dbbac720d85","sha256:5bd1a4a8d72103ac02f70a6cf08ad3cd8971fb8e360fda430cf323132ab06b35"],"state_sha256":"99ea4db4995ba00ee3540e70493abcad7eb5126dda9fa79eef1930d2184ae907"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"pIamycsz5gzXisg8Xhoelxt1LBsx0bu+T6gfSwY9KhzDDBqfyytKveBxH+eQKxf/NICgM0c9BM7sAvfKhEnVCg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-24T04:05:53.773958Z","bundle_sha256":"dca836964af3fab75adf457fb34ee7d0aaef536c77743687b015dc1b010c3f1f"}}