{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:5BJSX4Y2U7BHS3PA4JORYAWLPM","short_pith_number":"pith:5BJSX4Y2","canonical_record":{"source":{"id":"2506.00673","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2025-05-31T18:53:19Z","cross_cats_sorted":[],"title_canon_sha256":"52cd2df66891b31dc086a939ad1fea051ae4d03f4fe67e58103c3b64cf796888","abstract_canon_sha256":"6a55d47b79d6a6a999fdc1f914c94842c336101e6cc00e1afb9b326125094eb7"},"schema_version":"1.0"},"canonical_sha256":"e8532bf31aa7c2796de0e25d1c02cb7b2fb8e9b142ff4417564490545894b803","source":{"kind":"arxiv","id":"2506.00673","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.00673","created_at":"2026-07-05T11:13:38Z"},{"alias_kind":"arxiv_version","alias_value":"2506.00673v1","created_at":"2026-07-05T11:13:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.00673","created_at":"2026-07-05T11:13:38Z"},{"alias_kind":"pith_short_12","alias_value":"5BJSX4Y2U7BH","created_at":"2026-07-05T11:13:38Z"},{"alias_kind":"pith_short_16","alias_value":"5BJSX4Y2U7BHS3PA","created_at":"2026-07-05T11:13:38Z"},{"alias_kind":"pith_short_8","alias_value":"5BJSX4Y2","created_at":"2026-07-05T11:13:38Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:5BJSX4Y2U7BHS3PA4JORYAWLPM","target":"record","payload":{"canonical_record":{"source":{"id":"2506.00673","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2025-05-31T18:53:19Z","cross_cats_sorted":[],"title_canon_sha256":"52cd2df66891b31dc086a939ad1fea051ae4d03f4fe67e58103c3b64cf796888","abstract_canon_sha256":"6a55d47b79d6a6a999fdc1f914c94842c336101e6cc00e1afb9b326125094eb7"},"schema_version":"1.0"},"canonical_sha256":"e8532bf31aa7c2796de0e25d1c02cb7b2fb8e9b142ff4417564490545894b803","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:13:38.613925Z","signature_b64":"qZEBLeg1wSyrY8j30sxQMSP/wvv9y7afna6IXO3pQ8XpK7eO+v9ejTogEjilTudiUo1O9rSPM6zRGOj/PdmdDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"e8532bf31aa7c2796de0e25d1c02cb7b2fb8e9b142ff4417564490545894b803","last_reissued_at":"2026-07-05T11:13:38.613409Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:13:38.613409Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2506.00673","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:13:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"B8lmUL4WA5ct8G3DwySvcTknIJdU62+2bovYRE8aau0OKM9rKb50JPtZWw9hxddS38iWzre+oWbmsfkverncBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-07T22:38:05.369840Z"},"content_sha256":"25fa22380ab1198e98a704540c56c2b685974238651af67e05e8a33966ecb28c","schema_version":"1.0","event_id":"sha256:25fa22380ab1198e98a704540c56c2b685974238651af67e05e8a33966ecb28c"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:5BJSX4Y2U7BHS3PA4JORYAWLPM","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"DuAL-Net: A Hybrid Framework for Alzheimer's Disease Prediction from Whole-Genome Sequencing via Local SNP Windows and Global Annotations","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.GN","authors_text":"Eun Hye Lee, Taeho Jo","submitted_at":"2025-05-31T18:53:19Z","abstract_excerpt":"Alzheimer's disease (AD) dementia is the most common form of dementia. With the emergence of disease-modifying therapies, predicting disease risk before symptom onset has become critical. We introduce DuAL-Net, a hybrid deep learning framework for AD dementia prediction using whole genome sequencing (WGS) data. DuAL-Net integrates two components: local probability modeling, which segments the genome into non-overlapping windows, and global annotation-based modeling, which annotates SNPs and reorganizes WGS input to capture long-range functional relationships. Both employ out-of-fold stacking w"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.00673","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2506.00673/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:13:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"l0mkHWyQOzEVHeXAM4gGBYnqOTqUTpyE9Y3gurKZUGOJIFis+ygn6PoPsXwPjMfWJsbmwYyMs5Mc5f9Ye6EqCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-07T22:38:05.370212Z"},"content_sha256":"0e66cf8dc753b09fefd7a5443f95cb08d1b5e8cb757a611f5928845fad14d9b6","schema_version":"1.0","event_id":"sha256:0e66cf8dc753b09fefd7a5443f95cb08d1b5e8cb757a611f5928845fad14d9b6"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/5BJSX4Y2U7BHS3PA4JORYAWLPM/bundle.json","state_url":"https://pith.science/pith/5BJSX4Y2U7BHS3PA4JORYAWLPM/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/5BJSX4Y2U7BHS3PA4JORYAWLPM/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-07T22:38:05Z","links":{"resolver":"https://pith.science/pith/5BJSX4Y2U7BHS3PA4JORYAWLPM","bundle":"https://pith.science/pith/5BJSX4Y2U7BHS3PA4JORYAWLPM/bundle.json","state":"https://pith.science/pith/5BJSX4Y2U7BHS3PA4JORYAWLPM/state.json","well_known_bundle":"https://pith.science/.well-known/pith/5BJSX4Y2U7BHS3PA4JORYAWLPM/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:5BJSX4Y2U7BHS3PA4JORYAWLPM","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6a55d47b79d6a6a999fdc1f914c94842c336101e6cc00e1afb9b326125094eb7","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2025-05-31T18:53:19Z","title_canon_sha256":"52cd2df66891b31dc086a939ad1fea051ae4d03f4fe67e58103c3b64cf796888"},"schema_version":"1.0","source":{"id":"2506.00673","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.00673","created_at":"2026-07-05T11:13:38Z"},{"alias_kind":"arxiv_version","alias_value":"2506.00673v1","created_at":"2026-07-05T11:13:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.00673","created_at":"2026-07-05T11:13:38Z"},{"alias_kind":"pith_short_12","alias_value":"5BJSX4Y2U7BH","created_at":"2026-07-05T11:13:38Z"},{"alias_kind":"pith_short_16","alias_value":"5BJSX4Y2U7BHS3PA","created_at":"2026-07-05T11:13:38Z"},{"alias_kind":"pith_short_8","alias_value":"5BJSX4Y2","created_at":"2026-07-05T11:13:38Z"}],"graph_snapshots":[{"event_id":"sha256:0e66cf8dc753b09fefd7a5443f95cb08d1b5e8cb757a611f5928845fad14d9b6","target":"graph","created_at":"2026-07-05T11:13:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2506.00673/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Alzheimer's disease (AD) dementia is the most common form of dementia. With the emergence of disease-modifying therapies, predicting disease risk before symptom onset has become critical. We introduce DuAL-Net, a hybrid deep learning framework for AD dementia prediction using whole genome sequencing (WGS) data. DuAL-Net integrates two components: local probability modeling, which segments the genome into non-overlapping windows, and global annotation-based modeling, which annotates SNPs and reorganizes WGS input to capture long-range functional relationships. Both employ out-of-fold stacking w","authors_text":"Eun Hye Lee, Taeho Jo","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2025-05-31T18:53:19Z","title":"DuAL-Net: A Hybrid Framework for Alzheimer's Disease Prediction from Whole-Genome Sequencing via Local SNP Windows and Global Annotations"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.00673","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:25fa22380ab1198e98a704540c56c2b685974238651af67e05e8a33966ecb28c","target":"record","created_at":"2026-07-05T11:13:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6a55d47b79d6a6a999fdc1f914c94842c336101e6cc00e1afb9b326125094eb7","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2025-05-31T18:53:19Z","title_canon_sha256":"52cd2df66891b31dc086a939ad1fea051ae4d03f4fe67e58103c3b64cf796888"},"schema_version":"1.0","source":{"id":"2506.00673","kind":"arxiv","version":1}},"canonical_sha256":"e8532bf31aa7c2796de0e25d1c02cb7b2fb8e9b142ff4417564490545894b803","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e8532bf31aa7c2796de0e25d1c02cb7b2fb8e9b142ff4417564490545894b803","first_computed_at":"2026-07-05T11:13:38.613409Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:13:38.613409Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"qZEBLeg1wSyrY8j30sxQMSP/wvv9y7afna6IXO3pQ8XpK7eO+v9ejTogEjilTudiUo1O9rSPM6zRGOj/PdmdDQ==","signature_status":"signed_v1","signed_at":"2026-07-05T11:13:38.613925Z","signed_message":"canonical_sha256_bytes"},"source_id":"2506.00673","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:25fa22380ab1198e98a704540c56c2b685974238651af67e05e8a33966ecb28c","sha256:0e66cf8dc753b09fefd7a5443f95cb08d1b5e8cb757a611f5928845fad14d9b6"],"state_sha256":"fda57fa4e677f488a2a83ec464886693c30498bc813d7fbefc806a7bba924c18"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"5Nsn9qtDGNaQATKHdvEFQr2iFjKoT9Hag/3YtGUEKxeLdSJb9BpnKjCs0raNkvtdPGwcXBkRA4Q+3ir0KGsuDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-07T22:38:05.372976Z","bundle_sha256":"f49452fb67ddcfc2bac7138ea746a9b96fcaec0b0bc779b8198cfc0514db69fc"}}