{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2022:5EBVU6CJTKW2JTAABCRY34XHI3","short_pith_number":"pith:5EBVU6CJ","canonical_record":{"source":{"id":"2207.04333","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2022-07-09T20:07:49Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"51a7beb362a1806f3066800333f22dc0b111ed6fae4a7ca9753f8db91f30f770","abstract_canon_sha256":"b2831a08ab3346c9b355aa5c312b7bd6912fbff8296c605015f2ad9762b6ad70"},"schema_version":"1.0"},"canonical_sha256":"e9035a78499aada4cc0008a38df2e746ee64e077b3072f7d1058cfd1b68487e5","source":{"kind":"arxiv","id":"2207.04333","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2207.04333","created_at":"2026-07-05T04:38:57Z"},{"alias_kind":"arxiv_version","alias_value":"2207.04333v1","created_at":"2026-07-05T04:38:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2207.04333","created_at":"2026-07-05T04:38:57Z"},{"alias_kind":"pith_short_12","alias_value":"5EBVU6CJTKW2","created_at":"2026-07-05T04:38:57Z"},{"alias_kind":"pith_short_16","alias_value":"5EBVU6CJTKW2JTAA","created_at":"2026-07-05T04:38:57Z"},{"alias_kind":"pith_short_8","alias_value":"5EBVU6CJ","created_at":"2026-07-05T04:38:57Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2022:5EBVU6CJTKW2JTAABCRY34XHI3","target":"record","payload":{"canonical_record":{"source":{"id":"2207.04333","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2022-07-09T20:07:49Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"51a7beb362a1806f3066800333f22dc0b111ed6fae4a7ca9753f8db91f30f770","abstract_canon_sha256":"b2831a08ab3346c9b355aa5c312b7bd6912fbff8296c605015f2ad9762b6ad70"},"schema_version":"1.0"},"canonical_sha256":"e9035a78499aada4cc0008a38df2e746ee64e077b3072f7d1058cfd1b68487e5","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T04:38:57.933663Z","signature_b64":"vLHXFuoAmigtf8PNvGaeYMmJ7+RYVvn6gdfjRF7P6UtQlzJZ3nAfqxQfAZhBgEt+z+J0ULfU6vRXBlcCUjq/Bg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"e9035a78499aada4cc0008a38df2e746ee64e077b3072f7d1058cfd1b68487e5","last_reissued_at":"2026-07-05T04:38:57.933171Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T04:38:57.933171Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2207.04333","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T04:38:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"HbQ092Mwkld21xjehlrkajUJCbm7trUuoPXT7eds48jPR6ArtyIq5675U8jmeElg0WZlAu9ZmZOsFxTEhT90Dw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T17:07:37.922103Z"},"content_sha256":"8042f38c90f050d774495d3f7fc92d047c5bfd4fb13be59a509029a8583073b2","schema_version":"1.0","event_id":"sha256:8042f38c90f050d774495d3f7fc92d047c5bfd4fb13be59a509029a8583073b2"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2022:5EBVU6CJTKW2JTAABCRY34XHI3","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Emerging Patterns in the Continuum Representation of Protein-Lipid Fingerprints","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.LG"],"primary_cat":"q-bio.QM","authors_text":"Felice C Lightstone, Fikret Aydin, Harsh Bhatia, Helgi I Ing\\'olfsson, Konstantia Georgouli, Mark Heimann, Peer-Timo Bremer","submitted_at":"2022-07-09T20:07:49Z","abstract_excerpt":"Capturing intricate biological phenomena often requires multiscale modeling where coarse and inexpensive models are developed using limited components of expensive and high-fidelity models. Here, we consider such a multiscale framework in the context of cancer biology and address the challenge of evaluating the descriptive capabilities of a continuum model developed using 1-dimensional statistics from a molecular dynamics model. Using deep learning, we develop a highly predictive classification model that identifies complex and emergent behavior from the continuum model. With over 99.9% accura"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2207.04333","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2207.04333/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T04:38:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Lxdq0YrsGUrgW7sZc0sc9D+KhTufoSAlQZB9pSVQxFI2ZIycMwAlDbIr6lSE06P9x6vV8BUnCtowVIH/rj0GCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-06T17:07:37.922620Z"},"content_sha256":"098e47d7fc31ff4a5d97ce88996987bda47073ac97e92394b020206bec34aab8","schema_version":"1.0","event_id":"sha256:098e47d7fc31ff4a5d97ce88996987bda47073ac97e92394b020206bec34aab8"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/5EBVU6CJTKW2JTAABCRY34XHI3/bundle.json","state_url":"https://pith.science/pith/5EBVU6CJTKW2JTAABCRY34XHI3/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/5EBVU6CJTKW2JTAABCRY34XHI3/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-06T17:07:37Z","links":{"resolver":"https://pith.science/pith/5EBVU6CJTKW2JTAABCRY34XHI3","bundle":"https://pith.science/pith/5EBVU6CJTKW2JTAABCRY34XHI3/bundle.json","state":"https://pith.science/pith/5EBVU6CJTKW2JTAABCRY34XHI3/state.json","well_known_bundle":"https://pith.science/.well-known/pith/5EBVU6CJTKW2JTAABCRY34XHI3/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:5EBVU6CJTKW2JTAABCRY34XHI3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b2831a08ab3346c9b355aa5c312b7bd6912fbff8296c605015f2ad9762b6ad70","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2022-07-09T20:07:49Z","title_canon_sha256":"51a7beb362a1806f3066800333f22dc0b111ed6fae4a7ca9753f8db91f30f770"},"schema_version":"1.0","source":{"id":"2207.04333","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2207.04333","created_at":"2026-07-05T04:38:57Z"},{"alias_kind":"arxiv_version","alias_value":"2207.04333v1","created_at":"2026-07-05T04:38:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2207.04333","created_at":"2026-07-05T04:38:57Z"},{"alias_kind":"pith_short_12","alias_value":"5EBVU6CJTKW2","created_at":"2026-07-05T04:38:57Z"},{"alias_kind":"pith_short_16","alias_value":"5EBVU6CJTKW2JTAA","created_at":"2026-07-05T04:38:57Z"},{"alias_kind":"pith_short_8","alias_value":"5EBVU6CJ","created_at":"2026-07-05T04:38:57Z"}],"graph_snapshots":[{"event_id":"sha256:098e47d7fc31ff4a5d97ce88996987bda47073ac97e92394b020206bec34aab8","target":"graph","created_at":"2026-07-05T04:38:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2207.04333/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Capturing intricate biological phenomena often requires multiscale modeling where coarse and inexpensive models are developed using limited components of expensive and high-fidelity models. Here, we consider such a multiscale framework in the context of cancer biology and address the challenge of evaluating the descriptive capabilities of a continuum model developed using 1-dimensional statistics from a molecular dynamics model. Using deep learning, we develop a highly predictive classification model that identifies complex and emergent behavior from the continuum model. With over 99.9% accura","authors_text":"Felice C Lightstone, Fikret Aydin, Harsh Bhatia, Helgi I Ing\\'olfsson, Konstantia Georgouli, Mark Heimann, Peer-Timo Bremer","cross_cats":["cs.LG"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2022-07-09T20:07:49Z","title":"Emerging Patterns in the Continuum Representation of Protein-Lipid Fingerprints"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2207.04333","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8042f38c90f050d774495d3f7fc92d047c5bfd4fb13be59a509029a8583073b2","target":"record","created_at":"2026-07-05T04:38:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b2831a08ab3346c9b355aa5c312b7bd6912fbff8296c605015f2ad9762b6ad70","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2022-07-09T20:07:49Z","title_canon_sha256":"51a7beb362a1806f3066800333f22dc0b111ed6fae4a7ca9753f8db91f30f770"},"schema_version":"1.0","source":{"id":"2207.04333","kind":"arxiv","version":1}},"canonical_sha256":"e9035a78499aada4cc0008a38df2e746ee64e077b3072f7d1058cfd1b68487e5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"e9035a78499aada4cc0008a38df2e746ee64e077b3072f7d1058cfd1b68487e5","first_computed_at":"2026-07-05T04:38:57.933171Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T04:38:57.933171Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"vLHXFuoAmigtf8PNvGaeYMmJ7+RYVvn6gdfjRF7P6UtQlzJZ3nAfqxQfAZhBgEt+z+J0ULfU6vRXBlcCUjq/Bg==","signature_status":"signed_v1","signed_at":"2026-07-05T04:38:57.933663Z","signed_message":"canonical_sha256_bytes"},"source_id":"2207.04333","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8042f38c90f050d774495d3f7fc92d047c5bfd4fb13be59a509029a8583073b2","sha256:098e47d7fc31ff4a5d97ce88996987bda47073ac97e92394b020206bec34aab8"],"state_sha256":"1cff195d74a703283af1b1fecf52d601d8b69560197247ae023ec6d6bdeb903c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"6/Wo8aCx+FgAOR2TCYMueAYFx33MN3VbwFL6GV6qETRwBDOjo6lag5QcgtqDf9TewoDCIaaMZzN8HBGoYWihCg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-06T17:07:37.926821Z","bundle_sha256":"1e2ba880e648ae903f5dbea60a3733c98bf8d63acb0963f16a8d14ef3523d0b4"}}