{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:5JCFYMB64HQTFHF72CZKDYU6E6","short_pith_number":"pith:5JCFYMB6","canonical_record":{"source":{"id":"2109.13739","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.QM","submitted_at":"2021-08-18T20:12:14Z","cross_cats_sorted":[],"title_canon_sha256":"c8edf21b83dd390c80aa12e20aa0bb18608253a19ccd8b316384a56cd5b59997","abstract_canon_sha256":"e305413c7d3669ddbcfaa58c1a1f40313fcff92e26d1fb05242f33759413211a"},"schema_version":"1.0"},"canonical_sha256":"ea445c303ee1e1329cbfd0b2a1e29e2783f9e390dbb51e0a056a4805a206f2da","source":{"kind":"arxiv","id":"2109.13739","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2109.13739","created_at":"2026-07-05T03:19:24Z"},{"alias_kind":"arxiv_version","alias_value":"2109.13739v2","created_at":"2026-07-05T03:19:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2109.13739","created_at":"2026-07-05T03:19:24Z"},{"alias_kind":"pith_short_12","alias_value":"5JCFYMB64HQT","created_at":"2026-07-05T03:19:24Z"},{"alias_kind":"pith_short_16","alias_value":"5JCFYMB64HQTFHF7","created_at":"2026-07-05T03:19:24Z"},{"alias_kind":"pith_short_8","alias_value":"5JCFYMB6","created_at":"2026-07-05T03:19:24Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:5JCFYMB64HQTFHF72CZKDYU6E6","target":"record","payload":{"canonical_record":{"source":{"id":"2109.13739","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.QM","submitted_at":"2021-08-18T20:12:14Z","cross_cats_sorted":[],"title_canon_sha256":"c8edf21b83dd390c80aa12e20aa0bb18608253a19ccd8b316384a56cd5b59997","abstract_canon_sha256":"e305413c7d3669ddbcfaa58c1a1f40313fcff92e26d1fb05242f33759413211a"},"schema_version":"1.0"},"canonical_sha256":"ea445c303ee1e1329cbfd0b2a1e29e2783f9e390dbb51e0a056a4805a206f2da","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:19:24.650950Z","signature_b64":"w60R0I3FUD4aLxSH/DarZ60unThZpRZR31Pf4CmA2PW81aIGIc+dmLLhlGFoj/lV6eYWfUTMZpYISsbDbn9wCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ea445c303ee1e1329cbfd0b2a1e29e2783f9e390dbb51e0a056a4805a206f2da","last_reissued_at":"2026-07-05T03:19:24.650499Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:19:24.650499Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2109.13739","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:19:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ol/jwKzSVJ6Ay0GV64h5jF3gIZ8GFDGbVvUjYSt2N9nGiNrjx24UPdd3twkBarecNLFNGKsAiph6eI+134uUBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-07T03:23:48.924805Z"},"content_sha256":"f668c11da6aa1f50e31eb9f629a3e2e9cebcef2ae0b56d499cbbe18f85cd60ae","schema_version":"1.0","event_id":"sha256:f668c11da6aa1f50e31eb9f629a3e2e9cebcef2ae0b56d499cbbe18f85cd60ae"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:5JCFYMB64HQTFHF72CZKDYU6E6","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Bayesian hypothesis testing and hierarchical modelling of ivermectin effectiveness in treating Covid-19","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Martin Neil, Norman Fenton","submitted_at":"2021-08-18T20:12:14Z","abstract_excerpt":"Ivermectin is an antiparasitic drug that some have claimed is an effective treatment for reducing Covid-19 deaths. To test this claim, two recent peer reviewed papers both conducted a meta-analysis on a similar set of randomized controlled trials data, applying the same classical statistical approach. Although the statistical results were similar, one of the papers (Bryant et al, 2021) concluded that ivermectin was effective for reducing Covid-19 deaths, while the other (Roman et al, 2021) concluded that there was insufficient quality of evidence to support the conclusion Ivermectin was effect"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2109.13739","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2109.13739/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:19:24Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"KZtP7ZNo7enmpoQsCMb1IaahspdnjQe7ZHG6aMh3sAPkQMHvLt1COuiR5rN3po6DclV5Vj18NlWLujAEbUYpDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-07T03:23:48.925176Z"},"content_sha256":"8719b71b38269611ac09a85e382d730b971106f4235602431eaf503f94fce8e4","schema_version":"1.0","event_id":"sha256:8719b71b38269611ac09a85e382d730b971106f4235602431eaf503f94fce8e4"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/5JCFYMB64HQTFHF72CZKDYU6E6/bundle.json","state_url":"https://pith.science/pith/5JCFYMB64HQTFHF72CZKDYU6E6/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/5JCFYMB64HQTFHF72CZKDYU6E6/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-07T03:23:48Z","links":{"resolver":"https://pith.science/pith/5JCFYMB64HQTFHF72CZKDYU6E6","bundle":"https://pith.science/pith/5JCFYMB64HQTFHF72CZKDYU6E6/bundle.json","state":"https://pith.science/pith/5JCFYMB64HQTFHF72CZKDYU6E6/state.json","well_known_bundle":"https://pith.science/.well-known/pith/5JCFYMB64HQTFHF72CZKDYU6E6/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:5JCFYMB64HQTFHF72CZKDYU6E6","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e305413c7d3669ddbcfaa58c1a1f40313fcff92e26d1fb05242f33759413211a","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.QM","submitted_at":"2021-08-18T20:12:14Z","title_canon_sha256":"c8edf21b83dd390c80aa12e20aa0bb18608253a19ccd8b316384a56cd5b59997"},"schema_version":"1.0","source":{"id":"2109.13739","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2109.13739","created_at":"2026-07-05T03:19:24Z"},{"alias_kind":"arxiv_version","alias_value":"2109.13739v2","created_at":"2026-07-05T03:19:24Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2109.13739","created_at":"2026-07-05T03:19:24Z"},{"alias_kind":"pith_short_12","alias_value":"5JCFYMB64HQT","created_at":"2026-07-05T03:19:24Z"},{"alias_kind":"pith_short_16","alias_value":"5JCFYMB64HQTFHF7","created_at":"2026-07-05T03:19:24Z"},{"alias_kind":"pith_short_8","alias_value":"5JCFYMB6","created_at":"2026-07-05T03:19:24Z"}],"graph_snapshots":[{"event_id":"sha256:8719b71b38269611ac09a85e382d730b971106f4235602431eaf503f94fce8e4","target":"graph","created_at":"2026-07-05T03:19:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2109.13739/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Ivermectin is an antiparasitic drug that some have claimed is an effective treatment for reducing Covid-19 deaths. To test this claim, two recent peer reviewed papers both conducted a meta-analysis on a similar set of randomized controlled trials data, applying the same classical statistical approach. Although the statistical results were similar, one of the papers (Bryant et al, 2021) concluded that ivermectin was effective for reducing Covid-19 deaths, while the other (Roman et al, 2021) concluded that there was insufficient quality of evidence to support the conclusion Ivermectin was effect","authors_text":"Martin Neil, Norman Fenton","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.QM","submitted_at":"2021-08-18T20:12:14Z","title":"Bayesian hypothesis testing and hierarchical modelling of ivermectin effectiveness in treating Covid-19"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2109.13739","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f668c11da6aa1f50e31eb9f629a3e2e9cebcef2ae0b56d499cbbe18f85cd60ae","target":"record","created_at":"2026-07-05T03:19:24Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e305413c7d3669ddbcfaa58c1a1f40313fcff92e26d1fb05242f33759413211a","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.QM","submitted_at":"2021-08-18T20:12:14Z","title_canon_sha256":"c8edf21b83dd390c80aa12e20aa0bb18608253a19ccd8b316384a56cd5b59997"},"schema_version":"1.0","source":{"id":"2109.13739","kind":"arxiv","version":2}},"canonical_sha256":"ea445c303ee1e1329cbfd0b2a1e29e2783f9e390dbb51e0a056a4805a206f2da","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ea445c303ee1e1329cbfd0b2a1e29e2783f9e390dbb51e0a056a4805a206f2da","first_computed_at":"2026-07-05T03:19:24.650499Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:19:24.650499Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"w60R0I3FUD4aLxSH/DarZ60unThZpRZR31Pf4CmA2PW81aIGIc+dmLLhlGFoj/lV6eYWfUTMZpYISsbDbn9wCw==","signature_status":"signed_v1","signed_at":"2026-07-05T03:19:24.650950Z","signed_message":"canonical_sha256_bytes"},"source_id":"2109.13739","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f668c11da6aa1f50e31eb9f629a3e2e9cebcef2ae0b56d499cbbe18f85cd60ae","sha256:8719b71b38269611ac09a85e382d730b971106f4235602431eaf503f94fce8e4"],"state_sha256":"10cc0dde6aa4de2c88d4f6b3f263273abc834a69739d88e590e5e7a2a29618ee"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Yza04OaOpMoIZ3qF2++WCT5DOf6TwXa1x6hjKY3YyRNtHMTB8LIiDAyeHaN8Z1jZh0dtU9HqieKY9fBm8ehkDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-07T03:23:48.927075Z","bundle_sha256":"6abb20e9656bceacc048458c16d537c5f638a61bb15ad5d88069bf91db1b01f9"}}