{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2011:5K7TEMEP2VLPGRCDILT63FFOBN","short_pith_number":"pith:5K7TEMEP","canonical_record":{"source":{"id":"1112.5604","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-12-23T15:37:01Z","cross_cats_sorted":[],"title_canon_sha256":"f5c48c1eb0e62c1682f389e4282c92ea28ec45c6c776d6b1aaa2c19d53a95b67","abstract_canon_sha256":"be3e3177b18a622d52b5d76eb62364dc5db86ed7b62bebc4580656e764bc6cd5"},"schema_version":"1.0"},"canonical_sha256":"eabf32308fd556f3444342e7ed94ae0b52d348c9b18fa5d20f6cecf312aad0d0","source":{"kind":"arxiv","id":"1112.5604","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1112.5604","created_at":"2026-05-18T03:54:49Z"},{"alias_kind":"arxiv_version","alias_value":"1112.5604v1","created_at":"2026-05-18T03:54:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1112.5604","created_at":"2026-05-18T03:54:49Z"},{"alias_kind":"pith_short_12","alias_value":"5K7TEMEP2VLP","created_at":"2026-05-18T12:26:20Z"},{"alias_kind":"pith_short_16","alias_value":"5K7TEMEP2VLPGRCD","created_at":"2026-05-18T12:26:20Z"},{"alias_kind":"pith_short_8","alias_value":"5K7TEMEP","created_at":"2026-05-18T12:26:20Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2011:5K7TEMEP2VLPGRCDILT63FFOBN","target":"record","payload":{"canonical_record":{"source":{"id":"1112.5604","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-12-23T15:37:01Z","cross_cats_sorted":[],"title_canon_sha256":"f5c48c1eb0e62c1682f389e4282c92ea28ec45c6c776d6b1aaa2c19d53a95b67","abstract_canon_sha256":"be3e3177b18a622d52b5d76eb62364dc5db86ed7b62bebc4580656e764bc6cd5"},"schema_version":"1.0"},"canonical_sha256":"eabf32308fd556f3444342e7ed94ae0b52d348c9b18fa5d20f6cecf312aad0d0","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:54:49.158795Z","signature_b64":"g7X30rdwp+lVgVeedEguY7hp31uLhJNu1XD6P+9eOYb54OaRxlyQ33XqGqp+TilCrkdHMgM6szdVu6/MvRGLBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"eabf32308fd556f3444342e7ed94ae0b52d348c9b18fa5d20f6cecf312aad0d0","last_reissued_at":"2026-05-18T03:54:49.158351Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:54:49.158351Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1112.5604","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:54:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"iQwWTeP0McCuBUeBWFwAhoduQDv4D66Jmx8X8zs7PFpvhNZRScDwRLlV6FE5L5XhwjGgxd1ohIqB1y4M3pV3BA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T18:15:01.401200Z"},"content_sha256":"037a9379da4fc48b5d31cd8d75c2baecf144173515054fa38042355f82f692c0","schema_version":"1.0","event_id":"sha256:037a9379da4fc48b5d31cd8d75c2baecf144173515054fa38042355f82f692c0"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2011:5K7TEMEP2VLPGRCDILT63FFOBN","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Integration of cellular signals in chattering environments","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Antonio J. Pons, Jordi Garcia-Ojalvo, N\\'uria Domedel-Puig, Pau Ru\\'e","submitted_at":"2011-12-23T15:37:01Z","abstract_excerpt":"Cells are constantly exposed to fluctuating environmental conditions. External signals are sensed, processed and integrated by cellular signal transduction networks, which translate input signals into specific cellular responses by means of biochemical reactions. These networks have a complex nature, and we are still far from having a complete characterization of the process through which they integrate information, specially given the noisy environment in which that information is embedded. Guided by the many instances of constructive influences of noise that have been reported in the physica"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1112.5604","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:54:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JWRbncUmrWOwj3Ru7kV0wdRSD+0idR36rk2rmyBpO0Ka7SEqH5BJp2L+0pSSVkp3ggid3GA/cvOD7wjGSrUVAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T18:15:01.401585Z"},"content_sha256":"d12f9c76862ca6f6f09d64efa0f0293242a103676141d6d7be819bb257830a3e","schema_version":"1.0","event_id":"sha256:d12f9c76862ca6f6f09d64efa0f0293242a103676141d6d7be819bb257830a3e"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/5K7TEMEP2VLPGRCDILT63FFOBN/bundle.json","state_url":"https://pith.science/pith/5K7TEMEP2VLPGRCDILT63FFOBN/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/5K7TEMEP2VLPGRCDILT63FFOBN/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-04T18:15:01Z","links":{"resolver":"https://pith.science/pith/5K7TEMEP2VLPGRCDILT63FFOBN","bundle":"https://pith.science/pith/5K7TEMEP2VLPGRCDILT63FFOBN/bundle.json","state":"https://pith.science/pith/5K7TEMEP2VLPGRCDILT63FFOBN/state.json","well_known_bundle":"https://pith.science/.well-known/pith/5K7TEMEP2VLPGRCDILT63FFOBN/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:5K7TEMEP2VLPGRCDILT63FFOBN","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"be3e3177b18a622d52b5d76eb62364dc5db86ed7b62bebc4580656e764bc6cd5","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-12-23T15:37:01Z","title_canon_sha256":"f5c48c1eb0e62c1682f389e4282c92ea28ec45c6c776d6b1aaa2c19d53a95b67"},"schema_version":"1.0","source":{"id":"1112.5604","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1112.5604","created_at":"2026-05-18T03:54:49Z"},{"alias_kind":"arxiv_version","alias_value":"1112.5604v1","created_at":"2026-05-18T03:54:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1112.5604","created_at":"2026-05-18T03:54:49Z"},{"alias_kind":"pith_short_12","alias_value":"5K7TEMEP2VLP","created_at":"2026-05-18T12:26:20Z"},{"alias_kind":"pith_short_16","alias_value":"5K7TEMEP2VLPGRCD","created_at":"2026-05-18T12:26:20Z"},{"alias_kind":"pith_short_8","alias_value":"5K7TEMEP","created_at":"2026-05-18T12:26:20Z"}],"graph_snapshots":[{"event_id":"sha256:d12f9c76862ca6f6f09d64efa0f0293242a103676141d6d7be819bb257830a3e","target":"graph","created_at":"2026-05-18T03:54:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Cells are constantly exposed to fluctuating environmental conditions. External signals are sensed, processed and integrated by cellular signal transduction networks, which translate input signals into specific cellular responses by means of biochemical reactions. These networks have a complex nature, and we are still far from having a complete characterization of the process through which they integrate information, specially given the noisy environment in which that information is embedded. Guided by the many instances of constructive influences of noise that have been reported in the physica","authors_text":"Antonio J. Pons, Jordi Garcia-Ojalvo, N\\'uria Domedel-Puig, Pau Ru\\'e","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-12-23T15:37:01Z","title":"Integration of cellular signals in chattering environments"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1112.5604","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:037a9379da4fc48b5d31cd8d75c2baecf144173515054fa38042355f82f692c0","target":"record","created_at":"2026-05-18T03:54:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"be3e3177b18a622d52b5d76eb62364dc5db86ed7b62bebc4580656e764bc6cd5","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2011-12-23T15:37:01Z","title_canon_sha256":"f5c48c1eb0e62c1682f389e4282c92ea28ec45c6c776d6b1aaa2c19d53a95b67"},"schema_version":"1.0","source":{"id":"1112.5604","kind":"arxiv","version":1}},"canonical_sha256":"eabf32308fd556f3444342e7ed94ae0b52d348c9b18fa5d20f6cecf312aad0d0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"eabf32308fd556f3444342e7ed94ae0b52d348c9b18fa5d20f6cecf312aad0d0","first_computed_at":"2026-05-18T03:54:49.158351Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:54:49.158351Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"g7X30rdwp+lVgVeedEguY7hp31uLhJNu1XD6P+9eOYb54OaRxlyQ33XqGqp+TilCrkdHMgM6szdVu6/MvRGLBw==","signature_status":"signed_v1","signed_at":"2026-05-18T03:54:49.158795Z","signed_message":"canonical_sha256_bytes"},"source_id":"1112.5604","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:037a9379da4fc48b5d31cd8d75c2baecf144173515054fa38042355f82f692c0","sha256:d12f9c76862ca6f6f09d64efa0f0293242a103676141d6d7be819bb257830a3e"],"state_sha256":"92bbc1a4c3ed9ec14e208fdc1e83257d3d1168a31b30964d401b3d9f50618261"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"MAitdS36sF1RTz9N3IKNQ3LJXa3EBfRuyG3sT4fZKWqn/dj+s6CY8pFDrQuqXas9nO9M01H32MoLDik0+/+qDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-04T18:15:01.403915Z","bundle_sha256":"63060df36938cddb5b8a333f352f99e41f2a640325e84be607ad0bff2009fb6a"}}