{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:5KHNJQ23ECJBX4G2IA363OBEXX","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"bcf954a25a4dbab4df7a1de5b7860af1337b679b368b73617a740b30c4873e2f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.mtrl-sci","submitted_at":"2011-03-24T09:50:24Z","title_canon_sha256":"c9b1f8a9f1bd745d093de9c91d92fa62d263ea4fdc784ecd61fe9bcfa943243c"},"schema_version":"1.0","source":{"id":"1103.4711","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1103.4711","created_at":"2026-05-18T04:26:01Z"},{"alias_kind":"arxiv_version","alias_value":"1103.4711v1","created_at":"2026-05-18T04:26:01Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1103.4711","created_at":"2026-05-18T04:26:01Z"},{"alias_kind":"pith_short_12","alias_value":"5KHNJQ23ECJB","created_at":"2026-05-18T12:26:20Z"},{"alias_kind":"pith_short_16","alias_value":"5KHNJQ23ECJBX4G2","created_at":"2026-05-18T12:26:20Z"},{"alias_kind":"pith_short_8","alias_value":"5KHNJQ23","created_at":"2026-05-18T12:26:20Z"}],"graph_snapshots":[{"event_id":"sha256:c8ec780dfeec59496dab5bdfda0ce412370b9d43539413b88f0d28f2d0121b68","target":"graph","created_at":"2026-05-18T04:26:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Nanocomposite membranes based on thermosensitive, poly(N-isopropylacrylamide)-based nanogels and magnetite nanoparticles have been designed to achieve \"on-demand\" drug delivery upon the application of an oscillating magnetic field. On-off release of sodium fluorescein over multiple magnetic cycles has been successfully demonstrated using prototype membrane-based devices. The total drug dose delivered was directly proportional to the duration of the \"on\" pulse. The membranes were non-cytotoxic, biocompatible, and retained their switchable flux properties after 45 days of subcutaneous implantati","authors_text":"Daniel S. Kohane, Debora Lin, Gerardo F. Goya, Jesus Santamaria, Robert Langer, Robert Padera, Samantha Lau, Silvia Irusta, Todd Hoare","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.mtrl-sci","submitted_at":"2011-03-24T09:50:24Z","title":"A Magnetically-Triggered Composite Membrane for On-Demand Drug Delivery"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1103.4711","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:39132f6b7cc1e1cbca65a69739d039794ba6d9a21d643628e6129ffeeed4215a","target":"record","created_at":"2026-05-18T04:26:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"bcf954a25a4dbab4df7a1de5b7860af1337b679b368b73617a740b30c4873e2f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.mtrl-sci","submitted_at":"2011-03-24T09:50:24Z","title_canon_sha256":"c9b1f8a9f1bd745d093de9c91d92fa62d263ea4fdc784ecd61fe9bcfa943243c"},"schema_version":"1.0","source":{"id":"1103.4711","kind":"arxiv","version":1}},"canonical_sha256":"ea8ed4c35b20921bf0da4037edb824bdd76e2931c141c8ad34326dabd1b35d7f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ea8ed4c35b20921bf0da4037edb824bdd76e2931c141c8ad34326dabd1b35d7f","first_computed_at":"2026-05-18T04:26:01.025249Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:26:01.025249Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"KXC+cPNaVs7Fy1h21WZi1guSwWy4s4QL/vthNxJ3EAYB6Ww5vVws9UiK6YambqFocCe23w+zjIbwyKF6wJGUBg==","signature_status":"signed_v1","signed_at":"2026-05-18T04:26:01.025701Z","signed_message":"canonical_sha256_bytes"},"source_id":"1103.4711","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:39132f6b7cc1e1cbca65a69739d039794ba6d9a21d643628e6129ffeeed4215a","sha256:c8ec780dfeec59496dab5bdfda0ce412370b9d43539413b88f0d28f2d0121b68"],"state_sha256":"e319943e80c435ef46176c44f6148637159c92f749662651f5e5c3e6f43e13ae"}