{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:5PITOZTBEHYK364F3P2AZJPSSP","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"014ff42130404d2eb035b44b24be7d5f300b7902d30ce034a2c15f5fd81a338b","cross_cats_sorted":["q-bio.GN","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2011-04-12T12:08:54Z","title_canon_sha256":"e7327712e1432e887f0dce114247a1bf18b9c2cee11ed5fd2fabc8f69cda9fd8"},"schema_version":"1.0","source":{"id":"1104.2180","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1104.2180","created_at":"2026-05-18T04:24:35Z"},{"alias_kind":"arxiv_version","alias_value":"1104.2180v1","created_at":"2026-05-18T04:24:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1104.2180","created_at":"2026-05-18T04:24:35Z"},{"alias_kind":"pith_short_12","alias_value":"5PITOZTBEHYK","created_at":"2026-05-18T12:26:20Z"},{"alias_kind":"pith_short_16","alias_value":"5PITOZTBEHYK364F","created_at":"2026-05-18T12:26:20Z"},{"alias_kind":"pith_short_8","alias_value":"5PITOZTB","created_at":"2026-05-18T12:26:20Z"}],"graph_snapshots":[{"event_id":"sha256:60541f9d3f7080262489095ac2046dd92a89a7a15c951dba579cd06a907edd27","target":"graph","created_at":"2026-05-18T04:24:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In the past decade computational biology has grown from a cottage industry with a handful of researchers to an attractive interdisciplinary field, catching the attention and imagination of many quantitatively-minded scientists. Of interest to us is the key role played by the EM algorithm during this transformation. We survey the use of the EM algorithm in a few important computational biology problems surrounding the \"central dogma\"; of molecular biology: from DNA to RNA and then to proteins. Topics of this article include sequence motif discovery, protein sequence alignment, population geneti","authors_text":"Jun S. Liu, Xiaodan Fan, Yuan Yuan","cross_cats":["q-bio.GN","q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2011-04-12T12:08:54Z","title":"The EM Algorithm and the Rise of Computational Biology"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1104.2180","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:24ceb7e30b833f7b2e726e19d7a0bfe3fa847c9e36652c5d9a25e4d26ab089dd","target":"record","created_at":"2026-05-18T04:24:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"014ff42130404d2eb035b44b24be7d5f300b7902d30ce034a2c15f5fd81a338b","cross_cats_sorted":["q-bio.GN","q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2011-04-12T12:08:54Z","title_canon_sha256":"e7327712e1432e887f0dce114247a1bf18b9c2cee11ed5fd2fabc8f69cda9fd8"},"schema_version":"1.0","source":{"id":"1104.2180","kind":"arxiv","version":1}},"canonical_sha256":"ebd137666121f0adfb85dbf40ca5f293c7da3b6c30bf31c27948417bda05d116","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ebd137666121f0adfb85dbf40ca5f293c7da3b6c30bf31c27948417bda05d116","first_computed_at":"2026-05-18T04:24:35.791168Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:24:35.791168Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"r6T/LIM3ML4XQEnCcctKZY8rSQeGB5EWtordmuJ4Y+fbBnayCOEDvSGMt1gj3YA66xor9LaoZYsHMI1W4disDw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:24:35.791591Z","signed_message":"canonical_sha256_bytes"},"source_id":"1104.2180","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:24ceb7e30b833f7b2e726e19d7a0bfe3fa847c9e36652c5d9a25e4d26ab089dd","sha256:60541f9d3f7080262489095ac2046dd92a89a7a15c951dba579cd06a907edd27"],"state_sha256":"8c5a03ad69253a77bfa45a93cc036d7e0ef99a39765819afe96901d283f58860"}