{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2020:5PYRIBJJQNJMNC2DN6YVS4WDC7","short_pith_number":"pith:5PYRIBJJ","schema_version":"1.0","canonical_sha256":"ebf11405298352c68b436fb15972c317ffeeff58b4e809b413266fba629aaeb0","source":{"kind":"arxiv","id":"2012.00566","version":1},"attestation_state":"computed","paper":{"title":"Discovering novel cancer bio-markers in acquired lapatinib resistance using Bayesian methods","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"AKM Azad, Salem Alyami","submitted_at":"2020-11-30T14:58:04Z","abstract_excerpt":"Genes/Proteins do not work alone within our body, rather as a group they perform certain activities indicated as pathways. Signalling transduction pathways (STPs) are some of the important pathways that transmit biological signals from protein-to-protein controlling several cellular activities. However, many diseases such as cancer target some of these signalling pathways for their growth and malignance, but demystifying their underlying mechanisms are a very complicated tasks. In this study, we use a fully Bayesian approach to develop methodologies in discovering novel driver bio-markers in a"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2012.00566","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2020-11-30T14:58:04Z","cross_cats_sorted":[],"title_canon_sha256":"055e0e2e24e0674cdec66a8062016a45f038c0bc14d5653d8dd353faef9854ae","abstract_canon_sha256":"d8426294369041bc384a936e4ba19b89ce042802ec5640ca35a2f254fa334a2c"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:01:53.899862Z","signature_b64":"v3hSTeJb1vTqvVuqGFfAyoNRJcT2OLP4IMmRuQn3Z+RcJE8ZktxNuKpeVTyp/yfEf8qKakJdy3CgN/wxyRQsAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ebf11405298352c68b436fb15972c317ffeeff58b4e809b413266fba629aaeb0","last_reissued_at":"2026-07-05T03:01:53.899448Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:01:53.899448Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Discovering novel cancer bio-markers in acquired lapatinib resistance using Bayesian methods","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"AKM Azad, Salem Alyami","submitted_at":"2020-11-30T14:58:04Z","abstract_excerpt":"Genes/Proteins do not work alone within our body, rather as a group they perform certain activities indicated as pathways. Signalling transduction pathways (STPs) are some of the important pathways that transmit biological signals from protein-to-protein controlling several cellular activities. However, many diseases such as cancer target some of these signalling pathways for their growth and malignance, but demystifying their underlying mechanisms are a very complicated tasks. In this study, we use a fully Bayesian approach to develop methodologies in discovering novel driver bio-markers in a"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2012.00566","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2012.00566/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2012.00566","created_at":"2026-07-05T03:01:53.899504+00:00"},{"alias_kind":"arxiv_version","alias_value":"2012.00566v1","created_at":"2026-07-05T03:01:53.899504+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2012.00566","created_at":"2026-07-05T03:01:53.899504+00:00"},{"alias_kind":"pith_short_12","alias_value":"5PYRIBJJQNJM","created_at":"2026-07-05T03:01:53.899504+00:00"},{"alias_kind":"pith_short_16","alias_value":"5PYRIBJJQNJMNC2D","created_at":"2026-07-05T03:01:53.899504+00:00"},{"alias_kind":"pith_short_8","alias_value":"5PYRIBJJ","created_at":"2026-07-05T03:01:53.899504+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/5PYRIBJJQNJMNC2DN6YVS4WDC7","json":"https://pith.science/pith/5PYRIBJJQNJMNC2DN6YVS4WDC7.json","graph_json":"https://pith.science/api/pith-number/5PYRIBJJQNJMNC2DN6YVS4WDC7/graph.json","events_json":"https://pith.science/api/pith-number/5PYRIBJJQNJMNC2DN6YVS4WDC7/events.json","paper":"https://pith.science/paper/5PYRIBJJ"},"agent_actions":{"view_html":"https://pith.science/pith/5PYRIBJJQNJMNC2DN6YVS4WDC7","download_json":"https://pith.science/pith/5PYRIBJJQNJMNC2DN6YVS4WDC7.json","view_paper":"https://pith.science/paper/5PYRIBJJ","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2012.00566&json=true","fetch_graph":"https://pith.science/api/pith-number/5PYRIBJJQNJMNC2DN6YVS4WDC7/graph.json","fetch_events":"https://pith.science/api/pith-number/5PYRIBJJQNJMNC2DN6YVS4WDC7/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/5PYRIBJJQNJMNC2DN6YVS4WDC7/action/timestamp_anchor","attest_storage":"https://pith.science/pith/5PYRIBJJQNJMNC2DN6YVS4WDC7/action/storage_attestation","attest_author":"https://pith.science/pith/5PYRIBJJQNJMNC2DN6YVS4WDC7/action/author_attestation","sign_citation":"https://pith.science/pith/5PYRIBJJQNJMNC2DN6YVS4WDC7/action/citation_signature","submit_replication":"https://pith.science/pith/5PYRIBJJQNJMNC2DN6YVS4WDC7/action/replication_record"}},"created_at":"2026-07-05T03:01:53.899504+00:00","updated_at":"2026-07-05T03:01:53.899504+00:00"}