{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:5QIHRXXH5D4TJNGOHR44BYAB7H","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0b074fd1b8c0c046776c1395be971c71b03584dc8ccf49a23d385c2d9df63cbc","cross_cats_sorted":["cs.CE","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/3.0/","primary_cat":"cs.MA","submitted_at":"2014-12-17T16:14:55Z","title_canon_sha256":"58308b7d5d9cabe4c70965973288bbd8c6b7f1ad89fb8a7698da46dbe041a425"},"schema_version":"1.0","source":{"id":"1412.5459","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1412.5459","created_at":"2026-05-18T02:31:02Z"},{"alias_kind":"arxiv_version","alias_value":"1412.5459v1","created_at":"2026-05-18T02:31:02Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1412.5459","created_at":"2026-05-18T02:31:02Z"},{"alias_kind":"pith_short_12","alias_value":"5QIHRXXH5D4T","created_at":"2026-05-18T12:28:14Z"},{"alias_kind":"pith_short_16","alias_value":"5QIHRXXH5D4TJNGO","created_at":"2026-05-18T12:28:14Z"},{"alias_kind":"pith_short_8","alias_value":"5QIHRXXH","created_at":"2026-05-18T12:28:14Z"}],"graph_snapshots":[{"event_id":"sha256:f78115d777be0b4cd6e94de6d9b20b0615157ce537c5ac9495fe07acfa02f4d9","target":"graph","created_at":"2026-05-18T02:31:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The concentration gradient of the Bicoid morphogen, which is established during the early stages of a Drosophila melanogaster embryonic development, determines the differential spatial patterns of gene expression and subsequent cell fate determination. This is mainly achieved by diffusion elicited by the different concentrations of the Bicoid protein in the embryo. Such chemical dynamic progress can be simulated by stochastic models, particularly the Gillespie alogrithm. However, as with various modelling approaches in biology, each technique involves drawing assumptions and reducing the model","authors_text":"Mariam Kiran, Wei Liu","cross_cats":["cs.CE","q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by/3.0/","primary_cat":"cs.MA","submitted_at":"2014-12-17T16:14:55Z","title":"Converting a Systems Dynamic Model to an Agent-based model for studying the Bicoid morphogen gradient in Drosophila embryo"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1412.5459","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6dad9522383a03a8c6fca8f286b043e595d943c91db509ecd5ea157fcb330e4b","target":"record","created_at":"2026-05-18T02:31:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0b074fd1b8c0c046776c1395be971c71b03584dc8ccf49a23d385c2d9df63cbc","cross_cats_sorted":["cs.CE","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/3.0/","primary_cat":"cs.MA","submitted_at":"2014-12-17T16:14:55Z","title_canon_sha256":"58308b7d5d9cabe4c70965973288bbd8c6b7f1ad89fb8a7698da46dbe041a425"},"schema_version":"1.0","source":{"id":"1412.5459","kind":"arxiv","version":1}},"canonical_sha256":"ec1078dee7e8f934b4ce3c79c0e001f9e35d805baafae240cdcae1c081bf7fde","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ec1078dee7e8f934b4ce3c79c0e001f9e35d805baafae240cdcae1c081bf7fde","first_computed_at":"2026-05-18T02:31:02.931028Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:31:02.931028Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"e6naVoJ7Ku38twQulkkpnCckqcdfc/62lbKHf7F96KF64s4bfM1Bh0CwvQ5MyOD7pA1lmErklgSovAQfuniPDg==","signature_status":"signed_v1","signed_at":"2026-05-18T02:31:02.931408Z","signed_message":"canonical_sha256_bytes"},"source_id":"1412.5459","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6dad9522383a03a8c6fca8f286b043e595d943c91db509ecd5ea157fcb330e4b","sha256:f78115d777be0b4cd6e94de6d9b20b0615157ce537c5ac9495fe07acfa02f4d9"],"state_sha256":"1fd1133b0b117e95d61a58363185fb7bcffc713c7571baca0f420bb20b8dab27"}