{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:5R4KADHUTUPVT2XJCZWLVBLTVL","short_pith_number":"pith:5R4KADHU","canonical_record":{"source":{"id":"1003.2791","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-03-14T15:45:54Z","cross_cats_sorted":[],"title_canon_sha256":"adfc539b5bda9b36370a6893c0fb98e618441518b5342cae70aa76fce53b3fe5","abstract_canon_sha256":"2cc10af378c2ffce2d58fca06d1076e3e9da97bae943138f92773958a722f62e"},"schema_version":"1.0"},"canonical_sha256":"ec78a00cf49d1f59eae9166cba8573aaea3b15ba631399d71baf9118fad05019","source":{"kind":"arxiv","id":"1003.2791","version":3},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1003.2791","created_at":"2026-05-18T02:24:37Z"},{"alias_kind":"arxiv_version","alias_value":"1003.2791v3","created_at":"2026-05-18T02:24:37Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1003.2791","created_at":"2026-05-18T02:24:37Z"},{"alias_kind":"pith_short_12","alias_value":"5R4KADHUTUPV","created_at":"2026-05-18T12:26:04Z"},{"alias_kind":"pith_short_16","alias_value":"5R4KADHUTUPVT2XJ","created_at":"2026-05-18T12:26:04Z"},{"alias_kind":"pith_short_8","alias_value":"5R4KADHU","created_at":"2026-05-18T12:26:04Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:5R4KADHUTUPVT2XJCZWLVBLTVL","target":"record","payload":{"canonical_record":{"source":{"id":"1003.2791","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-03-14T15:45:54Z","cross_cats_sorted":[],"title_canon_sha256":"adfc539b5bda9b36370a6893c0fb98e618441518b5342cae70aa76fce53b3fe5","abstract_canon_sha256":"2cc10af378c2ffce2d58fca06d1076e3e9da97bae943138f92773958a722f62e"},"schema_version":"1.0"},"canonical_sha256":"ec78a00cf49d1f59eae9166cba8573aaea3b15ba631399d71baf9118fad05019","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:24:37.319983Z","signature_b64":"NWmxl/NnicW1G0MztMkJ6lKw5kqRtMOCXi4hTEM4zRr7T42j2gwPJKbpc5azhaLOhRtttQDn0/ajYUE3s13dBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ec78a00cf49d1f59eae9166cba8573aaea3b15ba631399d71baf9118fad05019","last_reissued_at":"2026-05-18T02:24:37.319361Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:24:37.319361Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1003.2791","source_version":3,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:24:37Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"mfyFWi+1vhRC6J+OS/q32ADr4JzznWbR+s/vgKJP7q03Kbp63GoWwjGlfoC2+34PazRJtocubn6kem9wrSu1BQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T17:50:54.542887Z"},"content_sha256":"824cf333300cc3b81aab17453e2816582cf5370225794d61ebc2f4b8df15d9fc","schema_version":"1.0","event_id":"sha256:824cf333300cc3b81aab17453e2816582cf5370225794d61ebc2f4b8df15d9fc"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:5R4KADHUTUPVT2XJCZWLVBLTVL","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Adaptive response and enlargement of dynamic range","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Naama Brenner, Tamar Friedlander","submitted_at":"2010-03-14T15:45:54Z","abstract_excerpt":"Many membrane channels and receptors exhibit adaptive, or desensitized, response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation. Adaptive response is thought to be related to various cellular functions such as homeostasis and enlargement of dynamic range by background compensation. Here we study the quantitative relation between adaptive response and background compensation within a modeling framework. We show that any particular type of adaptive response is neither sufficient nor necessary for adaptive enlargement of dynamic range. In particul"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1003.2791","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:24:37Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"AH3uDCJ8bzZ70mDywXuYChOhuUKgp5l6B8T/sAdBBcrX7Ar1QH1v42He4E2V/S6jfqdVLncIyPWoWLCvRIE7CQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T17:50:54.543233Z"},"content_sha256":"1bbc7a2344182a1c7e38556ea9917f62354d19da23d9d9ca76dd1724e3625a78","schema_version":"1.0","event_id":"sha256:1bbc7a2344182a1c7e38556ea9917f62354d19da23d9d9ca76dd1724e3625a78"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/5R4KADHUTUPVT2XJCZWLVBLTVL/bundle.json","state_url":"https://pith.science/pith/5R4KADHUTUPVT2XJCZWLVBLTVL/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/5R4KADHUTUPVT2XJCZWLVBLTVL/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-01T17:50:54Z","links":{"resolver":"https://pith.science/pith/5R4KADHUTUPVT2XJCZWLVBLTVL","bundle":"https://pith.science/pith/5R4KADHUTUPVT2XJCZWLVBLTVL/bundle.json","state":"https://pith.science/pith/5R4KADHUTUPVT2XJCZWLVBLTVL/state.json","well_known_bundle":"https://pith.science/.well-known/pith/5R4KADHUTUPVT2XJCZWLVBLTVL/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:5R4KADHUTUPVT2XJCZWLVBLTVL","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"2cc10af378c2ffce2d58fca06d1076e3e9da97bae943138f92773958a722f62e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-03-14T15:45:54Z","title_canon_sha256":"adfc539b5bda9b36370a6893c0fb98e618441518b5342cae70aa76fce53b3fe5"},"schema_version":"1.0","source":{"id":"1003.2791","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1003.2791","created_at":"2026-05-18T02:24:37Z"},{"alias_kind":"arxiv_version","alias_value":"1003.2791v3","created_at":"2026-05-18T02:24:37Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1003.2791","created_at":"2026-05-18T02:24:37Z"},{"alias_kind":"pith_short_12","alias_value":"5R4KADHUTUPV","created_at":"2026-05-18T12:26:04Z"},{"alias_kind":"pith_short_16","alias_value":"5R4KADHUTUPVT2XJ","created_at":"2026-05-18T12:26:04Z"},{"alias_kind":"pith_short_8","alias_value":"5R4KADHU","created_at":"2026-05-18T12:26:04Z"}],"graph_snapshots":[{"event_id":"sha256:1bbc7a2344182a1c7e38556ea9917f62354d19da23d9d9ca76dd1724e3625a78","target":"graph","created_at":"2026-05-18T02:24:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Many membrane channels and receptors exhibit adaptive, or desensitized, response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation. Adaptive response is thought to be related to various cellular functions such as homeostasis and enlargement of dynamic range by background compensation. Here we study the quantitative relation between adaptive response and background compensation within a modeling framework. We show that any particular type of adaptive response is neither sufficient nor necessary for adaptive enlargement of dynamic range. In particul","authors_text":"Naama Brenner, Tamar Friedlander","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-03-14T15:45:54Z","title":"Adaptive response and enlargement of dynamic range"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1003.2791","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:824cf333300cc3b81aab17453e2816582cf5370225794d61ebc2f4b8df15d9fc","target":"record","created_at":"2026-05-18T02:24:37Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"2cc10af378c2ffce2d58fca06d1076e3e9da97bae943138f92773958a722f62e","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-03-14T15:45:54Z","title_canon_sha256":"adfc539b5bda9b36370a6893c0fb98e618441518b5342cae70aa76fce53b3fe5"},"schema_version":"1.0","source":{"id":"1003.2791","kind":"arxiv","version":3}},"canonical_sha256":"ec78a00cf49d1f59eae9166cba8573aaea3b15ba631399d71baf9118fad05019","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ec78a00cf49d1f59eae9166cba8573aaea3b15ba631399d71baf9118fad05019","first_computed_at":"2026-05-18T02:24:37.319361Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:24:37.319361Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"NWmxl/NnicW1G0MztMkJ6lKw5kqRtMOCXi4hTEM4zRr7T42j2gwPJKbpc5azhaLOhRtttQDn0/ajYUE3s13dBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T02:24:37.319983Z","signed_message":"canonical_sha256_bytes"},"source_id":"1003.2791","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:824cf333300cc3b81aab17453e2816582cf5370225794d61ebc2f4b8df15d9fc","sha256:1bbc7a2344182a1c7e38556ea9917f62354d19da23d9d9ca76dd1724e3625a78"],"state_sha256":"42f50ebff19b422683cb558516e3198a243da8b3c35a50a610306ffc37a6cc14"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WvGKYgh5bLJmpT5Ylayo3W3HB91/a7sKP0eQk0YgtXpHAaudMInOnNli2OadrNPtNpxAm0n7/UXY19rPV7zpAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-01T17:50:54.545184Z","bundle_sha256":"e9047f7c1dcdc4cd69ed3daaf0481b3aa0bc87248fd865b7dcbbce1447c7f028"}}