{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:5UCP3TQXXMBB4FE7JOYWWBUALF","short_pith_number":"pith:5UCP3TQX","canonical_record":{"source":{"id":"1908.10511","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2019-08-28T00:58:02Z","cross_cats_sorted":[],"title_canon_sha256":"1c813c4e1123c82b18b16c6b2a4da8fb6fdca4cb2164352be0d75661143f6aa4","abstract_canon_sha256":"3dafc6ce4747241bb76d0c910e9275c8f0701135faac1843d7a758cf32699f05"},"schema_version":"1.0"},"canonical_sha256":"ed04fdce17bb021e149f4bb16b068059791e57ca8c2319a0753f58a60419a4ae","source":{"kind":"arxiv","id":"1908.10511","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1908.10511","created_at":"2026-07-05T01:04:01Z"},{"alias_kind":"arxiv_version","alias_value":"1908.10511v1","created_at":"2026-07-05T01:04:01Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1908.10511","created_at":"2026-07-05T01:04:01Z"},{"alias_kind":"pith_short_12","alias_value":"5UCP3TQXXMBB","created_at":"2026-07-05T01:04:01Z"},{"alias_kind":"pith_short_16","alias_value":"5UCP3TQXXMBB4FE7","created_at":"2026-07-05T01:04:01Z"},{"alias_kind":"pith_short_8","alias_value":"5UCP3TQX","created_at":"2026-07-05T01:04:01Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:5UCP3TQXXMBB4FE7JOYWWBUALF","target":"record","payload":{"canonical_record":{"source":{"id":"1908.10511","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2019-08-28T00:58:02Z","cross_cats_sorted":[],"title_canon_sha256":"1c813c4e1123c82b18b16c6b2a4da8fb6fdca4cb2164352be0d75661143f6aa4","abstract_canon_sha256":"3dafc6ce4747241bb76d0c910e9275c8f0701135faac1843d7a758cf32699f05"},"schema_version":"1.0"},"canonical_sha256":"ed04fdce17bb021e149f4bb16b068059791e57ca8c2319a0753f58a60419a4ae","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T01:04:01.248083Z","signature_b64":"MMx99Kp8nDpaYjcei3yXE1ZbytsW9TQ7jj4kvrWAgCsNJ0etzRFZrBiELE5KI40a+ZJhyOWkL1Tr5hlOLm+/Bw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ed04fdce17bb021e149f4bb16b068059791e57ca8c2319a0753f58a60419a4ae","last_reissued_at":"2026-07-05T01:04:01.247612Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T01:04:01.247612Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1908.10511","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T01:04:01Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WCwftu1mqa34tnxW6+B2bAfgREwi9w9niIc52MefwiOvCXWb+ImOwj2honJfwDiuzWQyrviV1YhvLijm27rsCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-24T01:10:55.849217Z"},"content_sha256":"743135c60854c7974433151d3ad6869e27cade7da9dae133365c1cb6f7d8e3f2","schema_version":"1.0","event_id":"sha256:743135c60854c7974433151d3ad6869e27cade7da9dae133365c1cb6f7d8e3f2"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:5UCP3TQXXMBB4FE7JOYWWBUALF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Effects of restrained degradation on gene expression and regulation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"Jian-Gong Ren, Jian-min Dong, Jing Sun, Yan-Ling Feng, Yi-Fan Liu","submitted_at":"2019-08-28T00:58:02Z","abstract_excerpt":"The effects of carrying capacity of environment $K$ for degradation (the $K$ effect for short) on the constitutive gene expression and a simple genetic regulation system, are investigated by employing a stochastic Langevin equation combined with the corresponding Fokker-Planck equation for the two stochastic systems subjected to internal and external noises. This $K$ effect characterizes the limited degradation ability of the environment for RNA or proteins, such as insufficient catabolic enzymes. The $K$ effect could significantly change the distribution of mRNA copy-number in constitutive ge"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1908.10511","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/1908.10511/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T01:04:01Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Hi1jpnC6NPeOO/q2hP//0kbedOl9ffYWfXT5lfoGqepljxxWmqP4c58s97B2n+21eairrt/RUKRrH/8BC0ouAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-24T01:10:55.849726Z"},"content_sha256":"25b228176137e0688ff173d3ed42b127e0c8095c9ba5a99ff5d15f18eefafe90","schema_version":"1.0","event_id":"sha256:25b228176137e0688ff173d3ed42b127e0c8095c9ba5a99ff5d15f18eefafe90"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/5UCP3TQXXMBB4FE7JOYWWBUALF/bundle.json","state_url":"https://pith.science/pith/5UCP3TQXXMBB4FE7JOYWWBUALF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/5UCP3TQXXMBB4FE7JOYWWBUALF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-24T01:10:55Z","links":{"resolver":"https://pith.science/pith/5UCP3TQXXMBB4FE7JOYWWBUALF","bundle":"https://pith.science/pith/5UCP3TQXXMBB4FE7JOYWWBUALF/bundle.json","state":"https://pith.science/pith/5UCP3TQXXMBB4FE7JOYWWBUALF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/5UCP3TQXXMBB4FE7JOYWWBUALF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:5UCP3TQXXMBB4FE7JOYWWBUALF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"3dafc6ce4747241bb76d0c910e9275c8f0701135faac1843d7a758cf32699f05","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2019-08-28T00:58:02Z","title_canon_sha256":"1c813c4e1123c82b18b16c6b2a4da8fb6fdca4cb2164352be0d75661143f6aa4"},"schema_version":"1.0","source":{"id":"1908.10511","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1908.10511","created_at":"2026-07-05T01:04:01Z"},{"alias_kind":"arxiv_version","alias_value":"1908.10511v1","created_at":"2026-07-05T01:04:01Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1908.10511","created_at":"2026-07-05T01:04:01Z"},{"alias_kind":"pith_short_12","alias_value":"5UCP3TQXXMBB","created_at":"2026-07-05T01:04:01Z"},{"alias_kind":"pith_short_16","alias_value":"5UCP3TQXXMBB4FE7","created_at":"2026-07-05T01:04:01Z"},{"alias_kind":"pith_short_8","alias_value":"5UCP3TQX","created_at":"2026-07-05T01:04:01Z"}],"graph_snapshots":[{"event_id":"sha256:25b228176137e0688ff173d3ed42b127e0c8095c9ba5a99ff5d15f18eefafe90","target":"graph","created_at":"2026-07-05T01:04:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/1908.10511/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The effects of carrying capacity of environment $K$ for degradation (the $K$ effect for short) on the constitutive gene expression and a simple genetic regulation system, are investigated by employing a stochastic Langevin equation combined with the corresponding Fokker-Planck equation for the two stochastic systems subjected to internal and external noises. This $K$ effect characterizes the limited degradation ability of the environment for RNA or proteins, such as insufficient catabolic enzymes. The $K$ effect could significantly change the distribution of mRNA copy-number in constitutive ge","authors_text":"Jian-Gong Ren, Jian-min Dong, Jing Sun, Yan-Ling Feng, Yi-Fan Liu","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2019-08-28T00:58:02Z","title":"Effects of restrained degradation on gene expression and regulation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1908.10511","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:743135c60854c7974433151d3ad6869e27cade7da9dae133365c1cb6f7d8e3f2","target":"record","created_at":"2026-07-05T01:04:01Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"3dafc6ce4747241bb76d0c910e9275c8f0701135faac1843d7a758cf32699f05","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2019-08-28T00:58:02Z","title_canon_sha256":"1c813c4e1123c82b18b16c6b2a4da8fb6fdca4cb2164352be0d75661143f6aa4"},"schema_version":"1.0","source":{"id":"1908.10511","kind":"arxiv","version":1}},"canonical_sha256":"ed04fdce17bb021e149f4bb16b068059791e57ca8c2319a0753f58a60419a4ae","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ed04fdce17bb021e149f4bb16b068059791e57ca8c2319a0753f58a60419a4ae","first_computed_at":"2026-07-05T01:04:01.247612Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T01:04:01.247612Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"MMx99Kp8nDpaYjcei3yXE1ZbytsW9TQ7jj4kvrWAgCsNJ0etzRFZrBiELE5KI40a+ZJhyOWkL1Tr5hlOLm+/Bw==","signature_status":"signed_v1","signed_at":"2026-07-05T01:04:01.248083Z","signed_message":"canonical_sha256_bytes"},"source_id":"1908.10511","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:743135c60854c7974433151d3ad6869e27cade7da9dae133365c1cb6f7d8e3f2","sha256:25b228176137e0688ff173d3ed42b127e0c8095c9ba5a99ff5d15f18eefafe90"],"state_sha256":"60697a9903121b5b83c1d51dcc549ba92e75ea7e3dcef5c5fdb65c20823cc854"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Sh0GkNbVaH+sfhFgkGetlW+29+JRXJQ5Hc0P6X9WK5ejWY9WMYAqApt6fqXgdWI3QIf9CfkIjBB48SkQGnS8Bg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-24T01:10:55.853521Z","bundle_sha256":"1217a87517720e1c46e2b6050f3fafa408aa7fa6a0a2797745a05c4fcc2d3304"}}