{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:5V6HN5KUP5LL2CURZADGEJXT2U","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1103792108f898bb2eff3d21fb5484f45ec93bc5b6e121cffbe1986421858ae6","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.SC","submitted_at":"2018-01-20T00:15:08Z","title_canon_sha256":"bd6268311ffe21bae15dc2e5b86ea49904f0ef63251bb5d123ab664545c710f2"},"schema_version":"1.0","source":{"id":"1801.06606","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1801.06606","created_at":"2026-05-18T00:25:28Z"},{"alias_kind":"arxiv_version","alias_value":"1801.06606v1","created_at":"2026-05-18T00:25:28Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1801.06606","created_at":"2026-05-18T00:25:28Z"},{"alias_kind":"pith_short_12","alias_value":"5V6HN5KUP5LL","created_at":"2026-05-18T12:32:08Z"},{"alias_kind":"pith_short_16","alias_value":"5V6HN5KUP5LL2CUR","created_at":"2026-05-18T12:32:08Z"},{"alias_kind":"pith_short_8","alias_value":"5V6HN5KU","created_at":"2026-05-18T12:32:08Z"}],"graph_snapshots":[{"event_id":"sha256:21dba624d95bd232d0e649aedb98381072d711a04c2e4f53e2662cacec5fe853","target":"graph","created_at":"2026-05-18T00:25:28Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Astrocytes express a large variety of G~protein-coupled receptors (GPCRs) which mediate the transduction of extracellular signals into intracellular calcium responses. This transduction is provided by a complex network of biochemical reactions which mobilizes a wealth of possible calcium-mobilizing second messenger molecules. Inositol 1,4,5-trisphosphate is probably the best known of these molecules whose enzymes for its production and degradation are nonetheless calcium-dependent. We present a biophysical modeling approach based on the assumption of Michaelis-Menten enzyme kinetics, to effect","authors_text":"Eshel Ben-Jacob, Hugues Berry, Maurizio De Pitt\\`a","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.SC","submitted_at":"2018-01-20T00:15:08Z","title":"G protein-coupled receptor-mediated calcium signaling in astrocytes"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1801.06606","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:3c137537ba113deb8372f9bdfd31c56db9ac38ccaa7f6edab09bd1c32983fd31","target":"record","created_at":"2026-05-18T00:25:28Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1103792108f898bb2eff3d21fb5484f45ec93bc5b6e121cffbe1986421858ae6","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.SC","submitted_at":"2018-01-20T00:15:08Z","title_canon_sha256":"bd6268311ffe21bae15dc2e5b86ea49904f0ef63251bb5d123ab664545c710f2"},"schema_version":"1.0","source":{"id":"1801.06606","kind":"arxiv","version":1}},"canonical_sha256":"ed7c76f5547f56bd0a91c8066226f3d51b150e6c760fe504112cff409bf89efa","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ed7c76f5547f56bd0a91c8066226f3d51b150e6c760fe504112cff409bf89efa","first_computed_at":"2026-05-18T00:25:28.237984Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:25:28.237984Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"0eMCYLgOt4uMxkYOGT/aui7+UDVYc+YtFNRHPE63x055WQLgpf5QsbkJrLALf4NbiOa9l+/bJL49Z7pRi6jiBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:25:28.238769Z","signed_message":"canonical_sha256_bytes"},"source_id":"1801.06606","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:3c137537ba113deb8372f9bdfd31c56db9ac38ccaa7f6edab09bd1c32983fd31","sha256:21dba624d95bd232d0e649aedb98381072d711a04c2e4f53e2662cacec5fe853"],"state_sha256":"9e0d91deb44ab605ceed2e90d607993b356496436e970a961e2ef4db85e34959"}