{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:5ZWBGBL45VDJHA7ZWQSMFF5VCA","short_pith_number":"pith:5ZWBGBL4","canonical_record":{"source":{"id":"1906.09861","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-06-24T11:35:37Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"e2c47d0c90a48a3fbf8285067b4324758da645ef19c95f78f822e37d85cace06","abstract_canon_sha256":"ca8920343d40aeab3fde1ee91ba3aaf5e2c5a6a190a5c7967618bb7ec70af30e"},"schema_version":"1.0"},"canonical_sha256":"ee6c13057ced469383f9b424c297b51039df9a2ee9d39e762e1f9a860e172a5d","source":{"kind":"arxiv","id":"1906.09861","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1906.09861","created_at":"2026-05-17T23:42:36Z"},{"alias_kind":"arxiv_version","alias_value":"1906.09861v1","created_at":"2026-05-17T23:42:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1906.09861","created_at":"2026-05-17T23:42:36Z"},{"alias_kind":"pith_short_12","alias_value":"5ZWBGBL45VDJ","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_16","alias_value":"5ZWBGBL45VDJHA7Z","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_8","alias_value":"5ZWBGBL4","created_at":"2026-05-18T12:33:10Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:5ZWBGBL45VDJHA7ZWQSMFF5VCA","target":"record","payload":{"canonical_record":{"source":{"id":"1906.09861","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-06-24T11:35:37Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"e2c47d0c90a48a3fbf8285067b4324758da645ef19c95f78f822e37d85cace06","abstract_canon_sha256":"ca8920343d40aeab3fde1ee91ba3aaf5e2c5a6a190a5c7967618bb7ec70af30e"},"schema_version":"1.0"},"canonical_sha256":"ee6c13057ced469383f9b424c297b51039df9a2ee9d39e762e1f9a860e172a5d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:42:36.432003Z","signature_b64":"Z/NqBsO12bKbmzHxcMP/AH3CyQWp7eXajzinDoEHshft7miuZ8Va9Dk8L7QXr4Qy3dN+SXmOV7mSNeG9qmb+CQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"ee6c13057ced469383f9b424c297b51039df9a2ee9d39e762e1f9a860e172a5d","last_reissued_at":"2026-05-17T23:42:36.431140Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:42:36.431140Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1906.09861","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:42:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"++XDR5YKLZc32OAUFFBMpEb25X4ohRXQ+6IK3XBEf4IOzTBtBydhFRUm2Ts9/rPg3TTv+O7nSukmY9AiaQLYAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T13:04:33.358950Z"},"content_sha256":"6c84fbafbff62b1a2710fbc9224bcb0ceea276c3ac196fd55917faacbf48d307","schema_version":"1.0","event_id":"sha256:6c84fbafbff62b1a2710fbc9224bcb0ceea276c3ac196fd55917faacbf48d307"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:5ZWBGBL45VDJHA7ZWQSMFF5VCA","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Independent channels for miRNA biosynthesis ensure efficient static and dynamic control in the regulation of the early stages of myogenesis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.MN","authors_text":"Andrea De Martino, Jonathan Fiorentino","submitted_at":"2019-06-24T11:35:37Z","abstract_excerpt":"Motivated by recent experimental work, we define and study a deterministic model of the complex miRNA-based regulatory circuit that putatively controls the early stage of myogenesis in human. We aim in particular at a quantitative understanding of (i) the roles played by the separate and independent miRNA biosynthesis channels (one involving a miRNA-decoy system regulated by an exogenous controller, the other given by transcription from a distinct genomic locus) that appear to be crucial for the differentiation program, and of (ii) how competition to bind miRNAs can efficiently control molecul"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1906.09861","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:42:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WqpO6Oyckk5jfnYKd9ksQx/H+Z9ApjkBBMMI/qBpXbEzAurYEl/AUu1Idwb/nlYzquGnUXSGlS1f97x7wgiZCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T13:04:33.359718Z"},"content_sha256":"d7d41f5592d3e6eaef6e04a20505e29c13c439b74aaee956e198aac432ad3f4a","schema_version":"1.0","event_id":"sha256:d7d41f5592d3e6eaef6e04a20505e29c13c439b74aaee956e198aac432ad3f4a"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/5ZWBGBL45VDJHA7ZWQSMFF5VCA/bundle.json","state_url":"https://pith.science/pith/5ZWBGBL45VDJHA7ZWQSMFF5VCA/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/5ZWBGBL45VDJHA7ZWQSMFF5VCA/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T13:04:33Z","links":{"resolver":"https://pith.science/pith/5ZWBGBL45VDJHA7ZWQSMFF5VCA","bundle":"https://pith.science/pith/5ZWBGBL45VDJHA7ZWQSMFF5VCA/bundle.json","state":"https://pith.science/pith/5ZWBGBL45VDJHA7ZWQSMFF5VCA/state.json","well_known_bundle":"https://pith.science/.well-known/pith/5ZWBGBL45VDJHA7ZWQSMFF5VCA/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:5ZWBGBL45VDJHA7ZWQSMFF5VCA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ca8920343d40aeab3fde1ee91ba3aaf5e2c5a6a190a5c7967618bb7ec70af30e","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-06-24T11:35:37Z","title_canon_sha256":"e2c47d0c90a48a3fbf8285067b4324758da645ef19c95f78f822e37d85cace06"},"schema_version":"1.0","source":{"id":"1906.09861","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1906.09861","created_at":"2026-05-17T23:42:36Z"},{"alias_kind":"arxiv_version","alias_value":"1906.09861v1","created_at":"2026-05-17T23:42:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1906.09861","created_at":"2026-05-17T23:42:36Z"},{"alias_kind":"pith_short_12","alias_value":"5ZWBGBL45VDJ","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_16","alias_value":"5ZWBGBL45VDJHA7Z","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_8","alias_value":"5ZWBGBL4","created_at":"2026-05-18T12:33:10Z"}],"graph_snapshots":[{"event_id":"sha256:d7d41f5592d3e6eaef6e04a20505e29c13c439b74aaee956e198aac432ad3f4a","target":"graph","created_at":"2026-05-17T23:42:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Motivated by recent experimental work, we define and study a deterministic model of the complex miRNA-based regulatory circuit that putatively controls the early stage of myogenesis in human. We aim in particular at a quantitative understanding of (i) the roles played by the separate and independent miRNA biosynthesis channels (one involving a miRNA-decoy system regulated by an exogenous controller, the other given by transcription from a distinct genomic locus) that appear to be crucial for the differentiation program, and of (ii) how competition to bind miRNAs can efficiently control molecul","authors_text":"Andrea De Martino, Jonathan Fiorentino","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-06-24T11:35:37Z","title":"Independent channels for miRNA biosynthesis ensure efficient static and dynamic control in the regulation of the early stages of myogenesis"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1906.09861","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6c84fbafbff62b1a2710fbc9224bcb0ceea276c3ac196fd55917faacbf48d307","target":"record","created_at":"2026-05-17T23:42:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ca8920343d40aeab3fde1ee91ba3aaf5e2c5a6a190a5c7967618bb7ec70af30e","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-06-24T11:35:37Z","title_canon_sha256":"e2c47d0c90a48a3fbf8285067b4324758da645ef19c95f78f822e37d85cace06"},"schema_version":"1.0","source":{"id":"1906.09861","kind":"arxiv","version":1}},"canonical_sha256":"ee6c13057ced469383f9b424c297b51039df9a2ee9d39e762e1f9a860e172a5d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"ee6c13057ced469383f9b424c297b51039df9a2ee9d39e762e1f9a860e172a5d","first_computed_at":"2026-05-17T23:42:36.431140Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:42:36.431140Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Z/NqBsO12bKbmzHxcMP/AH3CyQWp7eXajzinDoEHshft7miuZ8Va9Dk8L7QXr4Qy3dN+SXmOV7mSNeG9qmb+CQ==","signature_status":"signed_v1","signed_at":"2026-05-17T23:42:36.432003Z","signed_message":"canonical_sha256_bytes"},"source_id":"1906.09861","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6c84fbafbff62b1a2710fbc9224bcb0ceea276c3ac196fd55917faacbf48d307","sha256:d7d41f5592d3e6eaef6e04a20505e29c13c439b74aaee956e198aac432ad3f4a"],"state_sha256":"472c80c6ff1a6560c3818b55bf9d3b98c124972c02abae4f467b7195aa78e8ea"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"j1JdxG80pSu/KfVFY/KcqRemMJFrG0CK4yZeIZteXJH+HhRUfOfERo1UyBVJONDEjZlAe7Ls4+Gbslr/A9vACA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T13:04:33.364004Z","bundle_sha256":"942d5244f7fcea9b0804dab5574fd8252387e07e243bf1b8ccba5f38480e734b"}}