{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2022:64TBBI532DPOLE4DPVRE4DFR73","short_pith_number":"pith:64TBBI53","canonical_record":{"source":{"id":"2204.04838","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2022-04-11T02:54:18Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"ca279ad637c8aa4fbfa40637f6a33d5b3424854f583cc61744e4a2f13dc9cfdc","abstract_canon_sha256":"e91de91dd9fa43ad0998c0df869deb3e0b617235a4fe9f1940943bcebafe94c8"},"schema_version":"1.0"},"canonical_sha256":"f72610a3bbd0dee593837d624e0cb1fee8f91d05c2460bb8bbd41c0f42e1b7ad","source":{"kind":"arxiv","id":"2204.04838","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2204.04838","created_at":"2026-07-05T04:13:02Z"},{"alias_kind":"arxiv_version","alias_value":"2204.04838v1","created_at":"2026-07-05T04:13:02Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2204.04838","created_at":"2026-07-05T04:13:02Z"},{"alias_kind":"pith_short_12","alias_value":"64TBBI532DPO","created_at":"2026-07-05T04:13:02Z"},{"alias_kind":"pith_short_16","alias_value":"64TBBI532DPOLE4D","created_at":"2026-07-05T04:13:02Z"},{"alias_kind":"pith_short_8","alias_value":"64TBBI53","created_at":"2026-07-05T04:13:02Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2022:64TBBI532DPOLE4DPVRE4DFR73","target":"record","payload":{"canonical_record":{"source":{"id":"2204.04838","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2022-04-11T02:54:18Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"ca279ad637c8aa4fbfa40637f6a33d5b3424854f583cc61744e4a2f13dc9cfdc","abstract_canon_sha256":"e91de91dd9fa43ad0998c0df869deb3e0b617235a4fe9f1940943bcebafe94c8"},"schema_version":"1.0"},"canonical_sha256":"f72610a3bbd0dee593837d624e0cb1fee8f91d05c2460bb8bbd41c0f42e1b7ad","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T04:13:02.129119Z","signature_b64":"sMDg1AWeEzNOE+Qau7PzMJ4gu9GihJCcLYUjK0bSmE1SmlGp/8sufLXTN5gneB3HaH4oi0fUPA6Y9YTT/xiKDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f72610a3bbd0dee593837d624e0cb1fee8f91d05c2460bb8bbd41c0f42e1b7ad","last_reissued_at":"2026-07-05T04:13:02.128786Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T04:13:02.128786Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2204.04838","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T04:13:02Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2BS9fOk92/1hoW9bFD+rVDJUODU/1W6MV4B0ZApp0sfJyn9xXgavFZbz0uWhNITjEmQ5ULNTht4ej2Kv5MhNCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-06T20:37:46.568291Z"},"content_sha256":"a459e4c693ecba468e54e999f3d4e973f9736dcfec95b56a8f5cb910ee23d014","schema_version":"1.0","event_id":"sha256:a459e4c693ecba468e54e999f3d4e973f9736dcfec95b56a8f5cb910ee23d014"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2022:64TBBI532DPOLE4DPVRE4DFR73","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Robust Molecular Computation by Active Mechanics","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"cond-mat.soft","authors_text":"Kabir Husain, Madan Rao, Sriram Ramaswamy","submitted_at":"2022-04-11T02:54:18Z","abstract_excerpt":"The living cell expends energetic and material resources to reliably process information from its environment. To do so, it utilises unreliable molecular circuitry that is subject to thermal and other fluctuations. Here, we argue that active, physical processes can provide error correcting mechanisms for information processing. We analyse a model in which fluctuating receptor activation induces contractile stresses that recruit further receptors, dynamically controlling resource usage and accuracy. We show that this active scheme can outperform passive, static clusters (as formed, for instance"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2204.04838","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2204.04838/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T04:13:02Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Lzv3LWB4omXZ6VSFiS/8V+LtMGvZoM6FZl8TOfx9nzMZ62TlCh+mgnBjUqk0Uyn+IMT7F/opXfftEKn1mgwRDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-06T20:37:46.568692Z"},"content_sha256":"6d8b01c46d90d9cd63571a447f9b0a9e4f4c07555ca545d6562b23105779b4c6","schema_version":"1.0","event_id":"sha256:6d8b01c46d90d9cd63571a447f9b0a9e4f4c07555ca545d6562b23105779b4c6"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/64TBBI532DPOLE4DPVRE4DFR73/bundle.json","state_url":"https://pith.science/pith/64TBBI532DPOLE4DPVRE4DFR73/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/64TBBI532DPOLE4DPVRE4DFR73/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-06T20:37:46Z","links":{"resolver":"https://pith.science/pith/64TBBI532DPOLE4DPVRE4DFR73","bundle":"https://pith.science/pith/64TBBI532DPOLE4DPVRE4DFR73/bundle.json","state":"https://pith.science/pith/64TBBI532DPOLE4DPVRE4DFR73/state.json","well_known_bundle":"https://pith.science/.well-known/pith/64TBBI532DPOLE4DPVRE4DFR73/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:64TBBI532DPOLE4DPVRE4DFR73","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e91de91dd9fa43ad0998c0df869deb3e0b617235a4fe9f1940943bcebafe94c8","cross_cats_sorted":["physics.bio-ph"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2022-04-11T02:54:18Z","title_canon_sha256":"ca279ad637c8aa4fbfa40637f6a33d5b3424854f583cc61744e4a2f13dc9cfdc"},"schema_version":"1.0","source":{"id":"2204.04838","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2204.04838","created_at":"2026-07-05T04:13:02Z"},{"alias_kind":"arxiv_version","alias_value":"2204.04838v1","created_at":"2026-07-05T04:13:02Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2204.04838","created_at":"2026-07-05T04:13:02Z"},{"alias_kind":"pith_short_12","alias_value":"64TBBI532DPO","created_at":"2026-07-05T04:13:02Z"},{"alias_kind":"pith_short_16","alias_value":"64TBBI532DPOLE4D","created_at":"2026-07-05T04:13:02Z"},{"alias_kind":"pith_short_8","alias_value":"64TBBI53","created_at":"2026-07-05T04:13:02Z"}],"graph_snapshots":[{"event_id":"sha256:6d8b01c46d90d9cd63571a447f9b0a9e4f4c07555ca545d6562b23105779b4c6","target":"graph","created_at":"2026-07-05T04:13:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2204.04838/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The living cell expends energetic and material resources to reliably process information from its environment. To do so, it utilises unreliable molecular circuitry that is subject to thermal and other fluctuations. Here, we argue that active, physical processes can provide error correcting mechanisms for information processing. We analyse a model in which fluctuating receptor activation induces contractile stresses that recruit further receptors, dynamically controlling resource usage and accuracy. We show that this active scheme can outperform passive, static clusters (as formed, for instance","authors_text":"Kabir Husain, Madan Rao, Sriram Ramaswamy","cross_cats":["physics.bio-ph"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2022-04-11T02:54:18Z","title":"Robust Molecular Computation by Active Mechanics"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2204.04838","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a459e4c693ecba468e54e999f3d4e973f9736dcfec95b56a8f5cb910ee23d014","target":"record","created_at":"2026-07-05T04:13:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e91de91dd9fa43ad0998c0df869deb3e0b617235a4fe9f1940943bcebafe94c8","cross_cats_sorted":["physics.bio-ph"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2022-04-11T02:54:18Z","title_canon_sha256":"ca279ad637c8aa4fbfa40637f6a33d5b3424854f583cc61744e4a2f13dc9cfdc"},"schema_version":"1.0","source":{"id":"2204.04838","kind":"arxiv","version":1}},"canonical_sha256":"f72610a3bbd0dee593837d624e0cb1fee8f91d05c2460bb8bbd41c0f42e1b7ad","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f72610a3bbd0dee593837d624e0cb1fee8f91d05c2460bb8bbd41c0f42e1b7ad","first_computed_at":"2026-07-05T04:13:02.128786Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T04:13:02.128786Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"sMDg1AWeEzNOE+Qau7PzMJ4gu9GihJCcLYUjK0bSmE1SmlGp/8sufLXTN5gneB3HaH4oi0fUPA6Y9YTT/xiKDw==","signature_status":"signed_v1","signed_at":"2026-07-05T04:13:02.129119Z","signed_message":"canonical_sha256_bytes"},"source_id":"2204.04838","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a459e4c693ecba468e54e999f3d4e973f9736dcfec95b56a8f5cb910ee23d014","sha256:6d8b01c46d90d9cd63571a447f9b0a9e4f4c07555ca545d6562b23105779b4c6"],"state_sha256":"42f95b6eb80fd496f5ecd19a1899171c3f0918f4ed9e2a86c895535da404f03a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Y3ojviBc0cd/Mm01vhAphYo7lV69pFcLBvcXj+ioIRe7zjGT7C7Tqi6f/p2eUPnMdPdWWjyImmSH45eg9FqDAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-06T20:37:46.570834Z","bundle_sha256":"be8438fe5889c7937bac2839739d643264dc266cd7818031881a9b71a1dbc6fc"}}