{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:64TG66ZGHRBNBDMSHFAKA3GCX3","short_pith_number":"pith:64TG66ZG","canonical_record":{"source":{"id":"2101.01164","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2021-01-04T18:54:18Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"df123c6d563d0bd9ddb50f50c222fe0cee3c9a020c506ab08a98e0bfc8d5c56c","abstract_canon_sha256":"d70b5815a865c4518d139971d2965d7bbac9993eda1675223f58834d554f6369"},"schema_version":"1.0"},"canonical_sha256":"f7266f7b263c42d08d923940a06cc2becd64902fe2ed0baab8e6c2433d15c31c","source":{"kind":"arxiv","id":"2101.01164","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2101.01164","created_at":"2026-07-05T03:52:55Z"},{"alias_kind":"arxiv_version","alias_value":"2101.01164v1","created_at":"2026-07-05T03:52:55Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2101.01164","created_at":"2026-07-05T03:52:55Z"},{"alias_kind":"pith_short_12","alias_value":"64TG66ZGHRBN","created_at":"2026-07-05T03:52:55Z"},{"alias_kind":"pith_short_16","alias_value":"64TG66ZGHRBNBDMS","created_at":"2026-07-05T03:52:55Z"},{"alias_kind":"pith_short_8","alias_value":"64TG66ZG","created_at":"2026-07-05T03:52:55Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:64TG66ZGHRBNBDMSHFAKA3GCX3","target":"record","payload":{"canonical_record":{"source":{"id":"2101.01164","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2021-01-04T18:54:18Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"df123c6d563d0bd9ddb50f50c222fe0cee3c9a020c506ab08a98e0bfc8d5c56c","abstract_canon_sha256":"d70b5815a865c4518d139971d2965d7bbac9993eda1675223f58834d554f6369"},"schema_version":"1.0"},"canonical_sha256":"f7266f7b263c42d08d923940a06cc2becd64902fe2ed0baab8e6c2433d15c31c","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T03:52:55.318088Z","signature_b64":"2lC3RWJnTGGEf7LKeFKAW9GPvXlxd7+1b6Ygb/JwMNDgzG32T9Yl/UEV8Q2R7wnnm9kKUr+5irMQXpi0gnj0AQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f7266f7b263c42d08d923940a06cc2becd64902fe2ed0baab8e6c2433d15c31c","last_reissued_at":"2026-07-05T03:52:55.317737Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T03:52:55.317737Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2101.01164","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:52:55Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"IX3MUY+luCU+D3xvXga1WkbvViq8hMjrPKgCTxgxK7tXeUsk1aXCVBDDBZaadBocZ6R0cI2fyQecQli/+zCwDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T03:31:09.045629Z"},"content_sha256":"9041c9b52e98226f2e82127bdad8aa709449fa4f616b2d46f7baee2320b0f4c0","schema_version":"1.0","event_id":"sha256:9041c9b52e98226f2e82127bdad8aa709449fa4f616b2d46f7baee2320b0f4c0"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:64TG66ZGHRBNBDMSHFAKA3GCX3","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Stoichiometry controls the dynamics of liquid condensates of associative proteins","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"cond-mat.soft","authors_text":"Ned S. Wingreen, Pierre Ronceray, Xichong Liu, Yaojun Zhang","submitted_at":"2021-01-04T18:54:18Z","abstract_excerpt":"Multivalent associative proteins with strong complementary interactions play a crucial role in phase separation of intracellular liquid condensates. We study the internal dynamics of such \"bond-network\" condensates comprised of two complementary proteins via scaling analysis and molecular dynamics. We find that when stoichiometry is balanced, relaxation slows down dramatically due to a scarcity of alternative partners following a bond break. This microscopic slow-down strongly affects the bulk diffusivity, viscosity and mixing, which provides a means to experimentally test our predictions."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2101.01164","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2101.01164/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T03:52:55Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"cF+21+puln3h/BtpdJlJzbmPVeJK6Ud1QLKofTAifh0QPO9I7xfijR7ql9KxBPA/gBBocARKROhFC/Uhte2jBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T03:31:09.046151Z"},"content_sha256":"c6822063573e0990ed7a17805bf7cd28eccdf8a7fce2eaefcce08c261923fde5","schema_version":"1.0","event_id":"sha256:c6822063573e0990ed7a17805bf7cd28eccdf8a7fce2eaefcce08c261923fde5"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/64TG66ZGHRBNBDMSHFAKA3GCX3/bundle.json","state_url":"https://pith.science/pith/64TG66ZGHRBNBDMSHFAKA3GCX3/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/64TG66ZGHRBNBDMSHFAKA3GCX3/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-19T03:31:09Z","links":{"resolver":"https://pith.science/pith/64TG66ZGHRBNBDMSHFAKA3GCX3","bundle":"https://pith.science/pith/64TG66ZGHRBNBDMSHFAKA3GCX3/bundle.json","state":"https://pith.science/pith/64TG66ZGHRBNBDMSHFAKA3GCX3/state.json","well_known_bundle":"https://pith.science/.well-known/pith/64TG66ZGHRBNBDMSHFAKA3GCX3/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:64TG66ZGHRBNBDMSHFAKA3GCX3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d70b5815a865c4518d139971d2965d7bbac9993eda1675223f58834d554f6369","cross_cats_sorted":["physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2021-01-04T18:54:18Z","title_canon_sha256":"df123c6d563d0bd9ddb50f50c222fe0cee3c9a020c506ab08a98e0bfc8d5c56c"},"schema_version":"1.0","source":{"id":"2101.01164","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2101.01164","created_at":"2026-07-05T03:52:55Z"},{"alias_kind":"arxiv_version","alias_value":"2101.01164v1","created_at":"2026-07-05T03:52:55Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2101.01164","created_at":"2026-07-05T03:52:55Z"},{"alias_kind":"pith_short_12","alias_value":"64TG66ZGHRBN","created_at":"2026-07-05T03:52:55Z"},{"alias_kind":"pith_short_16","alias_value":"64TG66ZGHRBNBDMS","created_at":"2026-07-05T03:52:55Z"},{"alias_kind":"pith_short_8","alias_value":"64TG66ZG","created_at":"2026-07-05T03:52:55Z"}],"graph_snapshots":[{"event_id":"sha256:c6822063573e0990ed7a17805bf7cd28eccdf8a7fce2eaefcce08c261923fde5","target":"graph","created_at":"2026-07-05T03:52:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2101.01164/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Multivalent associative proteins with strong complementary interactions play a crucial role in phase separation of intracellular liquid condensates. We study the internal dynamics of such \"bond-network\" condensates comprised of two complementary proteins via scaling analysis and molecular dynamics. We find that when stoichiometry is balanced, relaxation slows down dramatically due to a scarcity of alternative partners following a bond break. This microscopic slow-down strongly affects the bulk diffusivity, viscosity and mixing, which provides a means to experimentally test our predictions.","authors_text":"Ned S. Wingreen, Pierre Ronceray, Xichong Liu, Yaojun Zhang","cross_cats":["physics.bio-ph"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2021-01-04T18:54:18Z","title":"Stoichiometry controls the dynamics of liquid condensates of associative proteins"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2101.01164","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9041c9b52e98226f2e82127bdad8aa709449fa4f616b2d46f7baee2320b0f4c0","target":"record","created_at":"2026-07-05T03:52:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d70b5815a865c4518d139971d2965d7bbac9993eda1675223f58834d554f6369","cross_cats_sorted":["physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cond-mat.soft","submitted_at":"2021-01-04T18:54:18Z","title_canon_sha256":"df123c6d563d0bd9ddb50f50c222fe0cee3c9a020c506ab08a98e0bfc8d5c56c"},"schema_version":"1.0","source":{"id":"2101.01164","kind":"arxiv","version":1}},"canonical_sha256":"f7266f7b263c42d08d923940a06cc2becd64902fe2ed0baab8e6c2433d15c31c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f7266f7b263c42d08d923940a06cc2becd64902fe2ed0baab8e6c2433d15c31c","first_computed_at":"2026-07-05T03:52:55.317737Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:52:55.317737Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"2lC3RWJnTGGEf7LKeFKAW9GPvXlxd7+1b6Ygb/JwMNDgzG32T9Yl/UEV8Q2R7wnnm9kKUr+5irMQXpi0gnj0AQ==","signature_status":"signed_v1","signed_at":"2026-07-05T03:52:55.318088Z","signed_message":"canonical_sha256_bytes"},"source_id":"2101.01164","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9041c9b52e98226f2e82127bdad8aa709449fa4f616b2d46f7baee2320b0f4c0","sha256:c6822063573e0990ed7a17805bf7cd28eccdf8a7fce2eaefcce08c261923fde5"],"state_sha256":"4cc501815a6244579d43b94500f1d70ae69f596b35c86907d5ba457bf92a81b1"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"aFeguSuLhc7WcYijljStYin4ndU9orGflak4XE9/VzJhsLU5w7SEfPLFGZ6itlMkYyTbZKT4rI7eugujd78DBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-19T03:31:09.051666Z","bundle_sha256":"50f5efd45844c4b108fc84fb4bca2a69f8b5c5d4c8d3e0f100cd693c769e878a"}}