{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:65TEOPHKJGBRZPZRKVSEZ75L2X","short_pith_number":"pith:65TEOPHK","canonical_record":{"source":{"id":"1509.07258","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2015-09-24T07:12:16Z","cross_cats_sorted":[],"title_canon_sha256":"421c56035a11e88989257f12f0d136d36b7cd96eabee3f14c1235cb0f34f53ac","abstract_canon_sha256":"26f9ab0c7109327ee98e2fe973264446265739ef560f414707f9ac435b8b4215"},"schema_version":"1.0"},"canonical_sha256":"f766473cea49831cbf3155644cffabd5d5dc878001bd2820fa2290378b02d51d","source":{"kind":"arxiv","id":"1509.07258","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1509.07258","created_at":"2026-05-18T01:32:09Z"},{"alias_kind":"arxiv_version","alias_value":"1509.07258v1","created_at":"2026-05-18T01:32:09Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.07258","created_at":"2026-05-18T01:32:09Z"},{"alias_kind":"pith_short_12","alias_value":"65TEOPHKJGBR","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_16","alias_value":"65TEOPHKJGBRZPZR","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_8","alias_value":"65TEOPHK","created_at":"2026-05-18T12:29:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:65TEOPHKJGBRZPZRKVSEZ75L2X","target":"record","payload":{"canonical_record":{"source":{"id":"1509.07258","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2015-09-24T07:12:16Z","cross_cats_sorted":[],"title_canon_sha256":"421c56035a11e88989257f12f0d136d36b7cd96eabee3f14c1235cb0f34f53ac","abstract_canon_sha256":"26f9ab0c7109327ee98e2fe973264446265739ef560f414707f9ac435b8b4215"},"schema_version":"1.0"},"canonical_sha256":"f766473cea49831cbf3155644cffabd5d5dc878001bd2820fa2290378b02d51d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:32:09.430252Z","signature_b64":"SM5r3uY5o8dn8YF+UDvoX0R3F69pCTnGynKgzEAIUzMy1+jimolJNzzjUo32gOs68tiEO3sBJKMldVjsOEagDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f766473cea49831cbf3155644cffabd5d5dc878001bd2820fa2290378b02d51d","last_reissued_at":"2026-05-18T01:32:09.429610Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:32:09.429610Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1509.07258","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:32:09Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"5YOvJSH7ZZJ3QvQPSsSsk4gk/2ocAMAyg++z0efzjRbwuh1F7rXtfiqiuhcCPplhfmpuLMB2sG0yKGY//hCuDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T06:54:54.303472Z"},"content_sha256":"f32348a80ecfdfbe4c80ac0549c4793fb415a4dc12b98205cc3417543b4b4fb7","schema_version":"1.0","event_id":"sha256:f32348a80ecfdfbe4c80ac0549c4793fb415a4dc12b98205cc3417543b4b4fb7"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:65TEOPHKJGBRZPZRKVSEZ75L2X","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: A modeling study","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.NC","authors_text":"Anders M. Dale, Anna Devor, Aree Witoelar, Francesco Bettella, Gaute T. Einevoll, Geir Halnes, Ole A. Andreassen, Srdjan Djurovic, Tuomo M\\\"aki-Marttunen, Yunpeng Wang","submitted_at":"2015-09-24T07:12:16Z","abstract_excerpt":"Background: Recent genome-wide association studies (GWAS) have identified a large number of genetic risk factors for schizophrenia (SCZ) featuring ion channels and calcium transporters. For some of these risk factors, independent prior investigations have examined the effects of genetic alterations on the cellular electrical excitability and calcium homeostasis. In the present proof-of-concept study, we harnessed these experimental results for modeling of computational properties on layer V cortical pyramidal cell and identify possible common alterations in behavior across SCZ-related genes.\n "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.07258","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:32:09Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"RNWuJG54JC8JewxVBrozxlvq03YMp80Toum69tWLRbODhy0vqtqWWxEYjsrfs2nXZFKATLHhW8ztf5GWa6+lDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T06:54:54.303830Z"},"content_sha256":"42181f3df55d095e970050758e8f696d5495ca1b53ad11b8d67e3c4de5ef1481","schema_version":"1.0","event_id":"sha256:42181f3df55d095e970050758e8f696d5495ca1b53ad11b8d67e3c4de5ef1481"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/65TEOPHKJGBRZPZRKVSEZ75L2X/bundle.json","state_url":"https://pith.science/pith/65TEOPHKJGBRZPZRKVSEZ75L2X/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/65TEOPHKJGBRZPZRKVSEZ75L2X/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-04T06:54:54Z","links":{"resolver":"https://pith.science/pith/65TEOPHKJGBRZPZRKVSEZ75L2X","bundle":"https://pith.science/pith/65TEOPHKJGBRZPZRKVSEZ75L2X/bundle.json","state":"https://pith.science/pith/65TEOPHKJGBRZPZRKVSEZ75L2X/state.json","well_known_bundle":"https://pith.science/.well-known/pith/65TEOPHKJGBRZPZRKVSEZ75L2X/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:65TEOPHKJGBRZPZRKVSEZ75L2X","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"26f9ab0c7109327ee98e2fe973264446265739ef560f414707f9ac435b8b4215","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2015-09-24T07:12:16Z","title_canon_sha256":"421c56035a11e88989257f12f0d136d36b7cd96eabee3f14c1235cb0f34f53ac"},"schema_version":"1.0","source":{"id":"1509.07258","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1509.07258","created_at":"2026-05-18T01:32:09Z"},{"alias_kind":"arxiv_version","alias_value":"1509.07258v1","created_at":"2026-05-18T01:32:09Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.07258","created_at":"2026-05-18T01:32:09Z"},{"alias_kind":"pith_short_12","alias_value":"65TEOPHKJGBR","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_16","alias_value":"65TEOPHKJGBRZPZR","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_8","alias_value":"65TEOPHK","created_at":"2026-05-18T12:29:07Z"}],"graph_snapshots":[{"event_id":"sha256:42181f3df55d095e970050758e8f696d5495ca1b53ad11b8d67e3c4de5ef1481","target":"graph","created_at":"2026-05-18T01:32:09Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Background: Recent genome-wide association studies (GWAS) have identified a large number of genetic risk factors for schizophrenia (SCZ) featuring ion channels and calcium transporters. For some of these risk factors, independent prior investigations have examined the effects of genetic alterations on the cellular electrical excitability and calcium homeostasis. In the present proof-of-concept study, we harnessed these experimental results for modeling of computational properties on layer V cortical pyramidal cell and identify possible common alterations in behavior across SCZ-related genes.\n ","authors_text":"Anders M. Dale, Anna Devor, Aree Witoelar, Francesco Bettella, Gaute T. Einevoll, Geir Halnes, Ole A. Andreassen, Srdjan Djurovic, Tuomo M\\\"aki-Marttunen, Yunpeng Wang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2015-09-24T07:12:16Z","title":"Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: A modeling study"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.07258","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f32348a80ecfdfbe4c80ac0549c4793fb415a4dc12b98205cc3417543b4b4fb7","target":"record","created_at":"2026-05-18T01:32:09Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"26f9ab0c7109327ee98e2fe973264446265739ef560f414707f9ac435b8b4215","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.NC","submitted_at":"2015-09-24T07:12:16Z","title_canon_sha256":"421c56035a11e88989257f12f0d136d36b7cd96eabee3f14c1235cb0f34f53ac"},"schema_version":"1.0","source":{"id":"1509.07258","kind":"arxiv","version":1}},"canonical_sha256":"f766473cea49831cbf3155644cffabd5d5dc878001bd2820fa2290378b02d51d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f766473cea49831cbf3155644cffabd5d5dc878001bd2820fa2290378b02d51d","first_computed_at":"2026-05-18T01:32:09.429610Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:32:09.429610Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"SM5r3uY5o8dn8YF+UDvoX0R3F69pCTnGynKgzEAIUzMy1+jimolJNzzjUo32gOs68tiEO3sBJKMldVjsOEagDQ==","signature_status":"signed_v1","signed_at":"2026-05-18T01:32:09.430252Z","signed_message":"canonical_sha256_bytes"},"source_id":"1509.07258","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f32348a80ecfdfbe4c80ac0549c4793fb415a4dc12b98205cc3417543b4b4fb7","sha256:42181f3df55d095e970050758e8f696d5495ca1b53ad11b8d67e3c4de5ef1481"],"state_sha256":"22c16cb8cc227223a5e22049d80e526f6940230ffe96f8c260eb3de0f9bcc044"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"5+pd3RiOv00XsxIncBPlHJeP1Dw2V7JWLFpjPXx4Edc01g2SDhOyysh58zjyFj/oVf90tBTHuRpLO9nz8xA1DQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-04T06:54:54.306239Z","bundle_sha256":"d036c4b84d2543ab75a1f62f5347dd479ae4b4051cd296e4fbb94b4d131b6cd5"}}