{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:66G53QSB755625BXM32VEUN4KQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"331282b8fd56d998ca66196f76724b87563633218d45323213c3239d30ccdc43","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-11-19T19:05:32Z","title_canon_sha256":"55c4201bfadd5b3ed61b76faa3e6b6df0a4bb7b09e696d3019ba1f59b2fa59af"},"schema_version":"1.0","source":{"id":"1411.5360","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1411.5360","created_at":"2026-05-18T00:54:03Z"},{"alias_kind":"arxiv_version","alias_value":"1411.5360v1","created_at":"2026-05-18T00:54:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1411.5360","created_at":"2026-05-18T00:54:03Z"},{"alias_kind":"pith_short_12","alias_value":"66G53QSB7556","created_at":"2026-05-18T12:28:16Z"},{"alias_kind":"pith_short_16","alias_value":"66G53QSB755625BX","created_at":"2026-05-18T12:28:16Z"},{"alias_kind":"pith_short_8","alias_value":"66G53QSB","created_at":"2026-05-18T12:28:16Z"}],"graph_snapshots":[{"event_id":"sha256:c54eb98b1e4191466f98ad7b1b1dc5c2b9b5acec0057207370b8c53e1166791d","target":"graph","created_at":"2026-05-18T00:54:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Dynamics and functions of G-protein coupled receptors (GPCRs) are accurately regulated by the type of ligands that bind to the orthosteric or allosteric binding sites. To glean the structural and dynamical origin of ligand-dependent modulation of GPCR activity, we performed total $\\sim$ 5 $\\mu$sec molecular dynamics simulations of A$_{2A}$ adenosine receptor (A$_{2A}$AR) in its apo, antagonist-bound, and agonist-bound forms in an explicit water and membrane environment, and examined the corresponding dynamics and correlation between the 10 key structural motifs that serve as the allosteric hot","authors_text":"Changbong Hyeon, Sun Choi, Yoonji Lee","cross_cats":["q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-11-19T19:05:32Z","title":"Communication over the network of binary switches regulates the activation of A$_{2A}$ adenosine receptor"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1411.5360","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f290a51efdcba69992710e46a6bb3c4f21729b1d4bd795799ac8c71149a06144","target":"record","created_at":"2026-05-18T00:54:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"331282b8fd56d998ca66196f76724b87563633218d45323213c3239d30ccdc43","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-11-19T19:05:32Z","title_canon_sha256":"55c4201bfadd5b3ed61b76faa3e6b6df0a4bb7b09e696d3019ba1f59b2fa59af"},"schema_version":"1.0","source":{"id":"1411.5360","kind":"arxiv","version":1}},"canonical_sha256":"f78dddc241ff7bed743766f55251bc5418aa620d5dba2b7c6561bde3c3eef37c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f78dddc241ff7bed743766f55251bc5418aa620d5dba2b7c6561bde3c3eef37c","first_computed_at":"2026-05-18T00:54:03.953213Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:54:03.953213Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"0e1iEE3khIYW1qsQWJ0dMDPtykTsx2OX+Jj+1ReGxrKWyIibaa3Uy8DGKq2UqiYCT692SkxbAns2cKXhmX+WAA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:54:03.953803Z","signed_message":"canonical_sha256_bytes"},"source_id":"1411.5360","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f290a51efdcba69992710e46a6bb3c4f21729b1d4bd795799ac8c71149a06144","sha256:c54eb98b1e4191466f98ad7b1b1dc5c2b9b5acec0057207370b8c53e1166791d"],"state_sha256":"b90d3373042624204b901d10572cc73c84d9edc10eba111e25194302e18b81f4"}