{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:66LKSV5OXT4UAFDEUHLVEGPHI6","short_pith_number":"pith:66LKSV5O","canonical_record":{"source":{"id":"1311.1861","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-11-08T01:20:51Z","cross_cats_sorted":[],"title_canon_sha256":"3ea634aeba4162c137c38950930fcbfd1fb5f75fceaa9c10ea503a30debf8794","abstract_canon_sha256":"acdcfc661f06c4a9a69ec1da1d248f341f8e1ff51bd613ec3aa647c43b0fed65"},"schema_version":"1.0"},"canonical_sha256":"f796a957aebcf9401464a1d75219e7478293483946b2e8c4ba8e148e215cad6e","source":{"kind":"arxiv","id":"1311.1861","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1311.1861","created_at":"2026-05-18T03:07:03Z"},{"alias_kind":"arxiv_version","alias_value":"1311.1861v2","created_at":"2026-05-18T03:07:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1311.1861","created_at":"2026-05-18T03:07:03Z"},{"alias_kind":"pith_short_12","alias_value":"66LKSV5OXT4U","created_at":"2026-05-18T12:27:36Z"},{"alias_kind":"pith_short_16","alias_value":"66LKSV5OXT4UAFDE","created_at":"2026-05-18T12:27:36Z"},{"alias_kind":"pith_short_8","alias_value":"66LKSV5O","created_at":"2026-05-18T12:27:36Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:66LKSV5OXT4UAFDEUHLVEGPHI6","target":"record","payload":{"canonical_record":{"source":{"id":"1311.1861","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-11-08T01:20:51Z","cross_cats_sorted":[],"title_canon_sha256":"3ea634aeba4162c137c38950930fcbfd1fb5f75fceaa9c10ea503a30debf8794","abstract_canon_sha256":"acdcfc661f06c4a9a69ec1da1d248f341f8e1ff51bd613ec3aa647c43b0fed65"},"schema_version":"1.0"},"canonical_sha256":"f796a957aebcf9401464a1d75219e7478293483946b2e8c4ba8e148e215cad6e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:07:03.442732Z","signature_b64":"JLC42qoX9lUMb7T1lIieq3amDCgiOG3P3u3GWVmbTjTC9xUB7PHbAeu3GfvQEWrkqowvLi8F6JMtX/VgwK0WDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f796a957aebcf9401464a1d75219e7478293483946b2e8c4ba8e148e215cad6e","last_reissued_at":"2026-05-18T03:07:03.442272Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:07:03.442272Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1311.1861","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:07:03Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TvAkVAsNoZsE+DDEktPzvPPFK+I1f+GQpeu4BSf+UQ6XWFxSdcS84WY0wHJw7g/LnNmD0PrqwEb6mVyN26AhAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-08T20:20:56.962784Z"},"content_sha256":"55d5a9e77b8545655a1ce10c514ace2d2d2fffe464b0c59f486dba1317ea5b30","schema_version":"1.0","event_id":"sha256:55d5a9e77b8545655a1ce10c514ace2d2d2fffe464b0c59f486dba1317ea5b30"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:66LKSV5OXT4UAFDEUHLVEGPHI6","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A stochastic microscopic model for the dynamics of antigenic variation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Fernando Alvarez-Valin, Gustavo Guerberoff","submitted_at":"2013-11-08T01:20:51Z","abstract_excerpt":"We present a novel model that describes the within-host evolutionary dynamics of parasites undergoing antigenic variation. The approach uses a multi-type branching process with two types of entities defined according to their relationship with the immune system: clans of resistant parasitic cells (i.e. groups of cells sharing the same antigen not yet recognized by the immune system) that may become sensitive, and individual sensitive cells that can acquire a new resistance thus giving rise to the emergence of a new clan. The simplicity of the model allows analytical treatment to determine the "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1311.1861","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:07:03Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kJqT695qiqo0yqRQvjz1Ol9E+Mhqna5tRemmbP3u81kcsyNks+JNBTQ3bxG6xdRGRcfeY9AU4WE1bQf2yzTgAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-08T20:20:56.963510Z"},"content_sha256":"60fa2a466d7dc95e15eb3a115296bfecfe875c9a84c1514c7e96f002106bb41d","schema_version":"1.0","event_id":"sha256:60fa2a466d7dc95e15eb3a115296bfecfe875c9a84c1514c7e96f002106bb41d"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/66LKSV5OXT4UAFDEUHLVEGPHI6/bundle.json","state_url":"https://pith.science/pith/66LKSV5OXT4UAFDEUHLVEGPHI6/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/66LKSV5OXT4UAFDEUHLVEGPHI6/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-08T20:20:56Z","links":{"resolver":"https://pith.science/pith/66LKSV5OXT4UAFDEUHLVEGPHI6","bundle":"https://pith.science/pith/66LKSV5OXT4UAFDEUHLVEGPHI6/bundle.json","state":"https://pith.science/pith/66LKSV5OXT4UAFDEUHLVEGPHI6/state.json","well_known_bundle":"https://pith.science/.well-known/pith/66LKSV5OXT4UAFDEUHLVEGPHI6/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:66LKSV5OXT4UAFDEUHLVEGPHI6","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"acdcfc661f06c4a9a69ec1da1d248f341f8e1ff51bd613ec3aa647c43b0fed65","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-11-08T01:20:51Z","title_canon_sha256":"3ea634aeba4162c137c38950930fcbfd1fb5f75fceaa9c10ea503a30debf8794"},"schema_version":"1.0","source":{"id":"1311.1861","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1311.1861","created_at":"2026-05-18T03:07:03Z"},{"alias_kind":"arxiv_version","alias_value":"1311.1861v2","created_at":"2026-05-18T03:07:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1311.1861","created_at":"2026-05-18T03:07:03Z"},{"alias_kind":"pith_short_12","alias_value":"66LKSV5OXT4U","created_at":"2026-05-18T12:27:36Z"},{"alias_kind":"pith_short_16","alias_value":"66LKSV5OXT4UAFDE","created_at":"2026-05-18T12:27:36Z"},{"alias_kind":"pith_short_8","alias_value":"66LKSV5O","created_at":"2026-05-18T12:27:36Z"}],"graph_snapshots":[{"event_id":"sha256:60fa2a466d7dc95e15eb3a115296bfecfe875c9a84c1514c7e96f002106bb41d","target":"graph","created_at":"2026-05-18T03:07:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We present a novel model that describes the within-host evolutionary dynamics of parasites undergoing antigenic variation. The approach uses a multi-type branching process with two types of entities defined according to their relationship with the immune system: clans of resistant parasitic cells (i.e. groups of cells sharing the same antigen not yet recognized by the immune system) that may become sensitive, and individual sensitive cells that can acquire a new resistance thus giving rise to the emergence of a new clan. The simplicity of the model allows analytical treatment to determine the ","authors_text":"Fernando Alvarez-Valin, Gustavo Guerberoff","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-11-08T01:20:51Z","title":"A stochastic microscopic model for the dynamics of antigenic variation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1311.1861","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:55d5a9e77b8545655a1ce10c514ace2d2d2fffe464b0c59f486dba1317ea5b30","target":"record","created_at":"2026-05-18T03:07:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"acdcfc661f06c4a9a69ec1da1d248f341f8e1ff51bd613ec3aa647c43b0fed65","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-11-08T01:20:51Z","title_canon_sha256":"3ea634aeba4162c137c38950930fcbfd1fb5f75fceaa9c10ea503a30debf8794"},"schema_version":"1.0","source":{"id":"1311.1861","kind":"arxiv","version":2}},"canonical_sha256":"f796a957aebcf9401464a1d75219e7478293483946b2e8c4ba8e148e215cad6e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f796a957aebcf9401464a1d75219e7478293483946b2e8c4ba8e148e215cad6e","first_computed_at":"2026-05-18T03:07:03.442272Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:07:03.442272Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"JLC42qoX9lUMb7T1lIieq3amDCgiOG3P3u3GWVmbTjTC9xUB7PHbAeu3GfvQEWrkqowvLi8F6JMtX/VgwK0WDQ==","signature_status":"signed_v1","signed_at":"2026-05-18T03:07:03.442732Z","signed_message":"canonical_sha256_bytes"},"source_id":"1311.1861","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:55d5a9e77b8545655a1ce10c514ace2d2d2fffe464b0c59f486dba1317ea5b30","sha256:60fa2a466d7dc95e15eb3a115296bfecfe875c9a84c1514c7e96f002106bb41d"],"state_sha256":"ddd98c03222ff8944f43daca1a515828c133f11d7d4faf2a082b073c3a565d5e"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"WemEdc86E0W9DU6v+M8sns3rw32gVmoMjWd3fGUzbCwfk1dQuDgCBa8ZICroD7HDCbHA+zEDJ//g+wb4vnGHDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-08T20:20:56.967443Z","bundle_sha256":"246c91e2bc6a9b32be663cf31bc965d0e3eb668df7dabec62866e684198fe2f9"}}