{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2012:6H7AA6IK3CZT5MKX3PIGQLFQGQ","short_pith_number":"pith:6H7AA6IK","canonical_record":{"source":{"id":"1202.6274","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-02-28T16:30:52Z","cross_cats_sorted":[],"title_canon_sha256":"71805488662f5acd74230aa258973f70659a46f902f69de4ebd96f8cb8e46db2","abstract_canon_sha256":"06befe526f6955cadbbafdf46e22ee8f34ee42d5239bcef3f81d311748ea20dc"},"schema_version":"1.0"},"canonical_sha256":"f1fe00790ad8b33eb157dbd0682cb0342b4b9986cb08f46fc3a2777ecae199ef","source":{"kind":"arxiv","id":"1202.6274","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1202.6274","created_at":"2026-05-18T04:01:13Z"},{"alias_kind":"arxiv_version","alias_value":"1202.6274v1","created_at":"2026-05-18T04:01:13Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1202.6274","created_at":"2026-05-18T04:01:13Z"},{"alias_kind":"pith_short_12","alias_value":"6H7AA6IK3CZT","created_at":"2026-05-18T12:26:56Z"},{"alias_kind":"pith_short_16","alias_value":"6H7AA6IK3CZT5MKX","created_at":"2026-05-18T12:26:56Z"},{"alias_kind":"pith_short_8","alias_value":"6H7AA6IK","created_at":"2026-05-18T12:26:56Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2012:6H7AA6IK3CZT5MKX3PIGQLFQGQ","target":"record","payload":{"canonical_record":{"source":{"id":"1202.6274","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-02-28T16:30:52Z","cross_cats_sorted":[],"title_canon_sha256":"71805488662f5acd74230aa258973f70659a46f902f69de4ebd96f8cb8e46db2","abstract_canon_sha256":"06befe526f6955cadbbafdf46e22ee8f34ee42d5239bcef3f81d311748ea20dc"},"schema_version":"1.0"},"canonical_sha256":"f1fe00790ad8b33eb157dbd0682cb0342b4b9986cb08f46fc3a2777ecae199ef","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:01:13.821031Z","signature_b64":"SxKFGAul1foQOzUa5mgEl5qi4qKzlTnSYr1mtMoocKS/2+b+wTL/vOiBR06gpdVpoUZNXR+Ixgf/cj9c3tLxAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f1fe00790ad8b33eb157dbd0682cb0342b4b9986cb08f46fc3a2777ecae199ef","last_reissued_at":"2026-05-18T04:01:13.820425Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:01:13.820425Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1202.6274","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:01:13Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"PuilHBFQgLlDjI4oPcLfH6djXOdHO+T/YAngGK43mX1qadYGZdOKjpXIvZnqMRvv0BCbeh00PpsHZfPzgOvOAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T08:55:22.524213Z"},"content_sha256":"b3420f96410e9d23cf64f39411d94fa35651c99274cc86a1585e801c1dccdadb","schema_version":"1.0","event_id":"sha256:b3420f96410e9d23cf64f39411d94fa35651c99274cc86a1585e801c1dccdadb"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2012:6H7AA6IK3CZT5MKX3PIGQLFQGQ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A new mechanism of development and differentiation through slow binding/unbinding of regulatory proteins to the genes","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Haidong Feng, Jin Wang","submitted_at":"2012-02-28T16:30:52Z","abstract_excerpt":"Understanding the differentiation, a biological process from a multipotent stem or progenitor state to a mature cell is critically important. We develop a theoretical framework to quantify the underlying potential landscape and biological paths for cell development and differentiation. We propose a new mechanism of differentiation and development through binding/unbinding of regulatory proteins to the gene promoters. We found indeed the differentiated states can emerge from the slow promoter binding/unbinding processes. Furthermore, under slow promoter binding/unbinding, we found multiple meta"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1202.6274","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:01:13Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"de+tNfFHgPaOSgE8PpaYP7wE6oXJo2hUylOjAAszMjaRMPseofcDh4d7UIn4S7nR5R9fbt8oLFuhbbd36FwQCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T08:55:22.524593Z"},"content_sha256":"8987fa597b15376921f8c93b8c8e1cdce9c9b1d813bbc742c827e4d9209464a2","schema_version":"1.0","event_id":"sha256:8987fa597b15376921f8c93b8c8e1cdce9c9b1d813bbc742c827e4d9209464a2"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/6H7AA6IK3CZT5MKX3PIGQLFQGQ/bundle.json","state_url":"https://pith.science/pith/6H7AA6IK3CZT5MKX3PIGQLFQGQ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/6H7AA6IK3CZT5MKX3PIGQLFQGQ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-03T08:55:22Z","links":{"resolver":"https://pith.science/pith/6H7AA6IK3CZT5MKX3PIGQLFQGQ","bundle":"https://pith.science/pith/6H7AA6IK3CZT5MKX3PIGQLFQGQ/bundle.json","state":"https://pith.science/pith/6H7AA6IK3CZT5MKX3PIGQLFQGQ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/6H7AA6IK3CZT5MKX3PIGQLFQGQ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:6H7AA6IK3CZT5MKX3PIGQLFQGQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"06befe526f6955cadbbafdf46e22ee8f34ee42d5239bcef3f81d311748ea20dc","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-02-28T16:30:52Z","title_canon_sha256":"71805488662f5acd74230aa258973f70659a46f902f69de4ebd96f8cb8e46db2"},"schema_version":"1.0","source":{"id":"1202.6274","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1202.6274","created_at":"2026-05-18T04:01:13Z"},{"alias_kind":"arxiv_version","alias_value":"1202.6274v1","created_at":"2026-05-18T04:01:13Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1202.6274","created_at":"2026-05-18T04:01:13Z"},{"alias_kind":"pith_short_12","alias_value":"6H7AA6IK3CZT","created_at":"2026-05-18T12:26:56Z"},{"alias_kind":"pith_short_16","alias_value":"6H7AA6IK3CZT5MKX","created_at":"2026-05-18T12:26:56Z"},{"alias_kind":"pith_short_8","alias_value":"6H7AA6IK","created_at":"2026-05-18T12:26:56Z"}],"graph_snapshots":[{"event_id":"sha256:8987fa597b15376921f8c93b8c8e1cdce9c9b1d813bbc742c827e4d9209464a2","target":"graph","created_at":"2026-05-18T04:01:13Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Understanding the differentiation, a biological process from a multipotent stem or progenitor state to a mature cell is critically important. We develop a theoretical framework to quantify the underlying potential landscape and biological paths for cell development and differentiation. We propose a new mechanism of differentiation and development through binding/unbinding of regulatory proteins to the gene promoters. We found indeed the differentiated states can emerge from the slow promoter binding/unbinding processes. Furthermore, under slow promoter binding/unbinding, we found multiple meta","authors_text":"Haidong Feng, Jin Wang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-02-28T16:30:52Z","title":"A new mechanism of development and differentiation through slow binding/unbinding of regulatory proteins to the genes"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1202.6274","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b3420f96410e9d23cf64f39411d94fa35651c99274cc86a1585e801c1dccdadb","target":"record","created_at":"2026-05-18T04:01:13Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"06befe526f6955cadbbafdf46e22ee8f34ee42d5239bcef3f81d311748ea20dc","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-02-28T16:30:52Z","title_canon_sha256":"71805488662f5acd74230aa258973f70659a46f902f69de4ebd96f8cb8e46db2"},"schema_version":"1.0","source":{"id":"1202.6274","kind":"arxiv","version":1}},"canonical_sha256":"f1fe00790ad8b33eb157dbd0682cb0342b4b9986cb08f46fc3a2777ecae199ef","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f1fe00790ad8b33eb157dbd0682cb0342b4b9986cb08f46fc3a2777ecae199ef","first_computed_at":"2026-05-18T04:01:13.820425Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:01:13.820425Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"SxKFGAul1foQOzUa5mgEl5qi4qKzlTnSYr1mtMoocKS/2+b+wTL/vOiBR06gpdVpoUZNXR+Ixgf/cj9c3tLxAw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:01:13.821031Z","signed_message":"canonical_sha256_bytes"},"source_id":"1202.6274","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b3420f96410e9d23cf64f39411d94fa35651c99274cc86a1585e801c1dccdadb","sha256:8987fa597b15376921f8c93b8c8e1cdce9c9b1d813bbc742c827e4d9209464a2"],"state_sha256":"f41628b8f2a72c9d1599a70e7c80b72f02e2677d520dfd01a1dbbfed25471dcc"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ImtkAnJJDvIIRn3t2p5SwMUf2yd1Xv+7BaqF0NWRHoqf8nXsl70j5o8xM1ncUkfHZJMjDkVtggr3ibBpfgkKCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-03T08:55:22.526535Z","bundle_sha256":"a3b835fe4ddcaa1d2ec10f46c1f8b3d843069161f85112de9529cba5c6c017cc"}}