{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2013:6KKF4KHQNUNNBG43VVFFKATLHA","short_pith_number":"pith:6KKF4KHQ","schema_version":"1.0","canonical_sha256":"f2945e28f06d1ad09b9bad4a55026b381bb74f39e443f5eec8e7af971178e746","source":{"kind":"arxiv","id":"1301.7734","version":1},"attestation_state":"computed","paper":{"title":"A mutate-and-map protocol for inferring base pairs in structured RNA","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Christopher C. VanLang, Pablo Cordero, Rhiju Das, Wipapat Kladwang","submitted_at":"2013-01-31T19:58:16Z","abstract_excerpt":"Chemical mapping is a widespread technique for structural analysis of nucleic acids in which a molecule's reactivity to different probes is quantified at single-nucleotide resolution and used to constrain structural modeling. This experimental framework has been extensively revisited in the past decade with new strategies for high-throughput read-outs, chemical modification, and rapid data analysis. Recently, we have coupled the technique to high-throughput mutagenesis. Point mutations of a base-paired nucleotide can lead to exposure of not only that nucleotide but also its interaction partner"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1301.7734","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2013-01-31T19:58:16Z","cross_cats_sorted":[],"title_canon_sha256":"17568f6383686c321498b03b9dbb50113b467cf5eaa8bee137ea7c9b53dc102c","abstract_canon_sha256":"6bd0c28888195cc3662b0da1328133793ebed8a03c894eedf863952c4c3f53ae"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:34:48.788438Z","signature_b64":"xkooMlc+rE1oiheUc8PfaWwuUI8oAe2xkRCysVKmha4cVFmvVfZSywgKiwsU7PJ7vHi7x/t3IJPMnyiQu0VZAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f2945e28f06d1ad09b9bad4a55026b381bb74f39e443f5eec8e7af971178e746","last_reissued_at":"2026-05-18T03:34:48.787695Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:34:48.787695Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"A mutate-and-map protocol for inferring base pairs in structured RNA","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Christopher C. VanLang, Pablo Cordero, Rhiju Das, Wipapat Kladwang","submitted_at":"2013-01-31T19:58:16Z","abstract_excerpt":"Chemical mapping is a widespread technique for structural analysis of nucleic acids in which a molecule's reactivity to different probes is quantified at single-nucleotide resolution and used to constrain structural modeling. This experimental framework has been extensively revisited in the past decade with new strategies for high-throughput read-outs, chemical modification, and rapid data analysis. Recently, we have coupled the technique to high-throughput mutagenesis. Point mutations of a base-paired nucleotide can lead to exposure of not only that nucleotide but also its interaction partner"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1301.7734","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1301.7734","created_at":"2026-05-18T03:34:48.787810+00:00"},{"alias_kind":"arxiv_version","alias_value":"1301.7734v1","created_at":"2026-05-18T03:34:48.787810+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1301.7734","created_at":"2026-05-18T03:34:48.787810+00:00"},{"alias_kind":"pith_short_12","alias_value":"6KKF4KHQNUNN","created_at":"2026-05-18T12:27:36.564083+00:00"},{"alias_kind":"pith_short_16","alias_value":"6KKF4KHQNUNNBG43","created_at":"2026-05-18T12:27:36.564083+00:00"},{"alias_kind":"pith_short_8","alias_value":"6KKF4KHQ","created_at":"2026-05-18T12:27:36.564083+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/6KKF4KHQNUNNBG43VVFFKATLHA","json":"https://pith.science/pith/6KKF4KHQNUNNBG43VVFFKATLHA.json","graph_json":"https://pith.science/api/pith-number/6KKF4KHQNUNNBG43VVFFKATLHA/graph.json","events_json":"https://pith.science/api/pith-number/6KKF4KHQNUNNBG43VVFFKATLHA/events.json","paper":"https://pith.science/paper/6KKF4KHQ"},"agent_actions":{"view_html":"https://pith.science/pith/6KKF4KHQNUNNBG43VVFFKATLHA","download_json":"https://pith.science/pith/6KKF4KHQNUNNBG43VVFFKATLHA.json","view_paper":"https://pith.science/paper/6KKF4KHQ","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1301.7734&json=true","fetch_graph":"https://pith.science/api/pith-number/6KKF4KHQNUNNBG43VVFFKATLHA/graph.json","fetch_events":"https://pith.science/api/pith-number/6KKF4KHQNUNNBG43VVFFKATLHA/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/6KKF4KHQNUNNBG43VVFFKATLHA/action/timestamp_anchor","attest_storage":"https://pith.science/pith/6KKF4KHQNUNNBG43VVFFKATLHA/action/storage_attestation","attest_author":"https://pith.science/pith/6KKF4KHQNUNNBG43VVFFKATLHA/action/author_attestation","sign_citation":"https://pith.science/pith/6KKF4KHQNUNNBG43VVFFKATLHA/action/citation_signature","submit_replication":"https://pith.science/pith/6KKF4KHQNUNNBG43VVFFKATLHA/action/replication_record"}},"created_at":"2026-05-18T03:34:48.787810+00:00","updated_at":"2026-05-18T03:34:48.787810+00:00"}