{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2024:6MNLI5WOLINW37POS4NUN46OHN","short_pith_number":"pith:6MNLI5WO","schema_version":"1.0","canonical_sha256":"f31ab476ce5a1b6dfdee971b46f3ce3b4a875f6fff8d9cb619447be82588c917","source":{"kind":"arxiv","id":"2412.14651","version":1},"attestation_state":"computed","paper":{"title":"Dual Photonics Probing of Nano- to Submicron-Scale Structural Alterations in Human Brain Tissues or Cells and Chromatin or DNA with the Progression of Alzheimers Disease","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["physics.bio-ph","physics.optics"],"primary_cat":"physics.med-ph","authors_text":"Dhruvil Solanki, Fatemah Alharthi, Himanshi Singh, Ishmael Apachigawo, Mohammad Moshahid Khan, Prabhakar Pradhan, Sazzad Khan","submitted_at":"2024-12-19T09:02:22Z","abstract_excerpt":"Understanding alterations in structural disorders in tissue or cells or building blocks, such as DNA or chromatin in the human brain, at the nano to submicron level provides us with efficient biomarkers for Alzheimers detection. Here, we report a dual photonics technique to detect nano- to submicron-scale alterations in brain tissues or cells and DNA or chromatin due to the early to late progression of Alzheimers disease in humans. Using a recently developed mesoscopic light transport technique, fine-focused nano-sensitive partial wave spectroscopy (PWS), we measure the degree of structural di"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2412.14651","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.med-ph","submitted_at":"2024-12-19T09:02:22Z","cross_cats_sorted":["physics.bio-ph","physics.optics"],"title_canon_sha256":"d6284e21e5fc42dc4e5215a0358f0169e2ecad2cab42634f2db641b849fcd3b5","abstract_canon_sha256":"317504508bb229b6a6de0ebf63c4a89e0bf530b92729f08d152c475548f01f26"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T09:51:50.779683Z","signature_b64":"QuMspEvWsUGiZPltruz6uQqsHLrol0xZsASn6cTZTVfWsJwRoAohZmtJ/4LuYsbf8pKqYKC49Z2qokYppGAXAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f31ab476ce5a1b6dfdee971b46f3ce3b4a875f6fff8d9cb619447be82588c917","last_reissued_at":"2026-07-05T09:51:50.779205Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T09:51:50.779205Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Dual Photonics Probing of Nano- to Submicron-Scale Structural Alterations in Human Brain Tissues or Cells and Chromatin or DNA with the Progression of Alzheimers Disease","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["physics.bio-ph","physics.optics"],"primary_cat":"physics.med-ph","authors_text":"Dhruvil Solanki, Fatemah Alharthi, Himanshi Singh, Ishmael Apachigawo, Mohammad Moshahid Khan, Prabhakar Pradhan, Sazzad Khan","submitted_at":"2024-12-19T09:02:22Z","abstract_excerpt":"Understanding alterations in structural disorders in tissue or cells or building blocks, such as DNA or chromatin in the human brain, at the nano to submicron level provides us with efficient biomarkers for Alzheimers detection. Here, we report a dual photonics technique to detect nano- to submicron-scale alterations in brain tissues or cells and DNA or chromatin due to the early to late progression of Alzheimers disease in humans. Using a recently developed mesoscopic light transport technique, fine-focused nano-sensitive partial wave spectroscopy (PWS), we measure the degree of structural di"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2412.14651","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2412.14651/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2412.14651","created_at":"2026-07-05T09:51:50.779263+00:00"},{"alias_kind":"arxiv_version","alias_value":"2412.14651v1","created_at":"2026-07-05T09:51:50.779263+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2412.14651","created_at":"2026-07-05T09:51:50.779263+00:00"},{"alias_kind":"pith_short_12","alias_value":"6MNLI5WOLINW","created_at":"2026-07-05T09:51:50.779263+00:00"},{"alias_kind":"pith_short_16","alias_value":"6MNLI5WOLINW37PO","created_at":"2026-07-05T09:51:50.779263+00:00"},{"alias_kind":"pith_short_8","alias_value":"6MNLI5WO","created_at":"2026-07-05T09:51:50.779263+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/6MNLI5WOLINW37POS4NUN46OHN","json":"https://pith.science/pith/6MNLI5WOLINW37POS4NUN46OHN.json","graph_json":"https://pith.science/api/pith-number/6MNLI5WOLINW37POS4NUN46OHN/graph.json","events_json":"https://pith.science/api/pith-number/6MNLI5WOLINW37POS4NUN46OHN/events.json","paper":"https://pith.science/paper/6MNLI5WO"},"agent_actions":{"view_html":"https://pith.science/pith/6MNLI5WOLINW37POS4NUN46OHN","download_json":"https://pith.science/pith/6MNLI5WOLINW37POS4NUN46OHN.json","view_paper":"https://pith.science/paper/6MNLI5WO","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2412.14651&json=true","fetch_graph":"https://pith.science/api/pith-number/6MNLI5WOLINW37POS4NUN46OHN/graph.json","fetch_events":"https://pith.science/api/pith-number/6MNLI5WOLINW37POS4NUN46OHN/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/6MNLI5WOLINW37POS4NUN46OHN/action/timestamp_anchor","attest_storage":"https://pith.science/pith/6MNLI5WOLINW37POS4NUN46OHN/action/storage_attestation","attest_author":"https://pith.science/pith/6MNLI5WOLINW37POS4NUN46OHN/action/author_attestation","sign_citation":"https://pith.science/pith/6MNLI5WOLINW37POS4NUN46OHN/action/citation_signature","submit_replication":"https://pith.science/pith/6MNLI5WOLINW37POS4NUN46OHN/action/replication_record"}},"created_at":"2026-07-05T09:51:50.779263+00:00","updated_at":"2026-07-05T09:51:50.779263+00:00"}