{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:6MSCNQY4UVKYPW5LOIPXCMKU46","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"4629493252258d28250ca0e73c483203b9bc62ca26b81e44bdc4c9e4275dbc9c","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2024-10-01T21:22:27Z","title_canon_sha256":"e2bd611ce40a84356bf642592272a28f12a1da2360d1045792c37b17a0d96228"},"schema_version":"1.0","source":{"id":"2410.01082","kind":"arxiv","version":5}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2410.01082","created_at":"2026-06-12T01:09:05Z"},{"alias_kind":"arxiv_version","alias_value":"2410.01082v5","created_at":"2026-06-12T01:09:05Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2410.01082","created_at":"2026-06-12T01:09:05Z"},{"alias_kind":"pith_short_12","alias_value":"6MSCNQY4UVKY","created_at":"2026-06-12T01:09:05Z"},{"alias_kind":"pith_short_16","alias_value":"6MSCNQY4UVKYPW5L","created_at":"2026-06-12T01:09:05Z"},{"alias_kind":"pith_short_8","alias_value":"6MSCNQY4","created_at":"2026-06-12T01:09:05Z"}],"graph_snapshots":[{"event_id":"sha256:60b9e9d5f2d1d6928c3b43e8e90d5e694c52449b3bdeb47ed200645d2747d66f","target":"graph","created_at":"2026-06-12T01:09:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2410.01082/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Glaucoma treatment relies on effective delivery of therapeutics to the anterior chamber; however, conventional approaches such as topical administration and intracameral injection are limited by rapid clearance and low intraocular bioavailability. In this study, a Computational Fluid Dynamics (CFD) framework was developed to comparatively evaluate drug transport, retention, and spatial distribution across three delivery strategies: intracameral injection, drug-eluting implants, and topical delivery via contact lens.","authors_text":"Cynthia Yu-Wai-Man, Daniel Sebastia-Saez, Naman Patel, Nazifa Begum, Robert Dinita, Umar Pitafi","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2024-10-01T21:22:27Z","title":"Comparative CFD modelling of drug and nanocarrier transport in the eye's anterior segment for glaucoma drug delivery via intracameral injection, drug-eluting implant and contact lens"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2410.01082","kind":"arxiv","version":5},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e364aa7940c5eb48ec73edf33d5df1f333e90fde2912ad4ae1ed8c660a8fc4fb","target":"record","created_at":"2026-06-12T01:09:05Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"4629493252258d28250ca0e73c483203b9bc62ca26b81e44bdc4c9e4275dbc9c","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2024-10-01T21:22:27Z","title_canon_sha256":"e2bd611ce40a84356bf642592272a28f12a1da2360d1045792c37b17a0d96228"},"schema_version":"1.0","source":{"id":"2410.01082","kind":"arxiv","version":5}},"canonical_sha256":"f32426c31ca55587dbab721f713154e7a93b0f3f59779888e7732fa236264a1b","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f32426c31ca55587dbab721f713154e7a93b0f3f59779888e7732fa236264a1b","first_computed_at":"2026-06-12T01:09:05.600845Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-12T01:09:05.600845Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"8h0pZnYiX90aiNqbWB8ojV/CU9XwKgTVVn0/ItewdcKnaxiScRWZyJc2QhD5VwFILWPIZbzU3V5RHJCqEt19DQ==","signature_status":"signed_v1","signed_at":"2026-06-12T01:09:05.601410Z","signed_message":"canonical_sha256_bytes"},"source_id":"2410.01082","source_kind":"arxiv","source_version":5}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e364aa7940c5eb48ec73edf33d5df1f333e90fde2912ad4ae1ed8c660a8fc4fb","sha256:60b9e9d5f2d1d6928c3b43e8e90d5e694c52449b3bdeb47ed200645d2747d66f"],"state_sha256":"cf0b33966270658d40f91249b0243bb606f7a659970e37437489333b99936dc4"}