{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:6MYL2ENYPQX2K4IQTJIV2MIZMG","short_pith_number":"pith:6MYL2ENY","canonical_record":{"source":{"id":"1812.05623","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2018-12-13T19:00:02Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"ba79f1fb3575bbf6556e017ec1766c0a402ee296c35c3720f1126fddefc2e1af","abstract_canon_sha256":"93e0cd87f0713e8acdc5a36065f2faaf67edcad3ec9c8f8617801411f99d1d94"},"schema_version":"1.0"},"canonical_sha256":"f330bd11b87c2fa571109a515d311961ba618aa1850ab7a440e70d49347d3740","source":{"kind":"arxiv","id":"1812.05623","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1812.05623","created_at":"2026-05-17T23:56:12Z"},{"alias_kind":"arxiv_version","alias_value":"1812.05623v1","created_at":"2026-05-17T23:56:12Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1812.05623","created_at":"2026-05-17T23:56:12Z"},{"alias_kind":"pith_short_12","alias_value":"6MYL2ENYPQX2","created_at":"2026-05-18T12:32:11Z"},{"alias_kind":"pith_short_16","alias_value":"6MYL2ENYPQX2K4IQ","created_at":"2026-05-18T12:32:11Z"},{"alias_kind":"pith_short_8","alias_value":"6MYL2ENY","created_at":"2026-05-18T12:32:11Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:6MYL2ENYPQX2K4IQTJIV2MIZMG","target":"record","payload":{"canonical_record":{"source":{"id":"1812.05623","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2018-12-13T19:00:02Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"ba79f1fb3575bbf6556e017ec1766c0a402ee296c35c3720f1126fddefc2e1af","abstract_canon_sha256":"93e0cd87f0713e8acdc5a36065f2faaf67edcad3ec9c8f8617801411f99d1d94"},"schema_version":"1.0"},"canonical_sha256":"f330bd11b87c2fa571109a515d311961ba618aa1850ab7a440e70d49347d3740","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:56:12.446783Z","signature_b64":"6Bm7LZ8RI61BZPAPglEw/X//oWZimalHzRdn9jRkkX90J35816d8jlBIc7j7dBHh2IPbqRcm2eSzvEX1afnGAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f330bd11b87c2fa571109a515d311961ba618aa1850ab7a440e70d49347d3740","last_reissued_at":"2026-05-17T23:56:12.446112Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:56:12.446112Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1812.05623","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:56:12Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DPyC9ONPkaiDdmuykCbMncUSxFPes7kgCf8QpDbL8mwjmkjCgyh8Q4fd26sJdZKEueQei5mUN8HviSbgMDkBBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T17:37:09.018666Z"},"content_sha256":"9c1db9869207d0562a455fc7d18df6961b5f680aab3029996aef893465229cb7","schema_version":"1.0","event_id":"sha256:9c1db9869207d0562a455fc7d18df6961b5f680aab3029996aef893465229cb7"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:6MYL2ENYPQX2K4IQTJIV2MIZMG","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Experimental evolution of diverse Escherichia coli metabolic mutants identifies genetic loci for convergent adaptation of growth rate","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.MN","authors_text":"Adilson E. Motter, Aleksandra Fergin, Aretha Fiebig, Jonathan W. Willett, Julien Herrou, Sean Crosson, Thomas P. Wytock","submitted_at":"2018-12-13T19:00:02Z","abstract_excerpt":"Cell growth is determined by substrate availability and the cell's metabolic capacity to assimilate substrates into building blocks. Metabolic genes that determine growth rate may interact synergistically or antagonistically, and can accelerate or slow growth, depending on the genetic background and environmental conditions. We evolved a diverse set of Escherichia coli single-gene deletion mutants with a spectrum of growth rates and identified mutations that generally increase growth rate. Despite the metabolic differences between parent strains, mutations that enhanced growth largely mapped t"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1812.05623","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:56:12Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"yliWnfDnaoCuE30+HYUJtP0zIrbyPS0NujN0BqKOuCsSwZFDVGKLRRoWYq5vrYfah1apkC12JVwqCPbMSAFVAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-09T17:37:09.019380Z"},"content_sha256":"e5abab7e2b9959cc31f353f458bdca87a0d20ef2f9cf031686e2d567fe23e48c","schema_version":"1.0","event_id":"sha256:e5abab7e2b9959cc31f353f458bdca87a0d20ef2f9cf031686e2d567fe23e48c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/6MYL2ENYPQX2K4IQTJIV2MIZMG/bundle.json","state_url":"https://pith.science/pith/6MYL2ENYPQX2K4IQTJIV2MIZMG/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/6MYL2ENYPQX2K4IQTJIV2MIZMG/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-09T17:37:09Z","links":{"resolver":"https://pith.science/pith/6MYL2ENYPQX2K4IQTJIV2MIZMG","bundle":"https://pith.science/pith/6MYL2ENYPQX2K4IQTJIV2MIZMG/bundle.json","state":"https://pith.science/pith/6MYL2ENYPQX2K4IQTJIV2MIZMG/state.json","well_known_bundle":"https://pith.science/.well-known/pith/6MYL2ENYPQX2K4IQTJIV2MIZMG/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:6MYL2ENYPQX2K4IQTJIV2MIZMG","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"93e0cd87f0713e8acdc5a36065f2faaf67edcad3ec9c8f8617801411f99d1d94","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2018-12-13T19:00:02Z","title_canon_sha256":"ba79f1fb3575bbf6556e017ec1766c0a402ee296c35c3720f1126fddefc2e1af"},"schema_version":"1.0","source":{"id":"1812.05623","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1812.05623","created_at":"2026-05-17T23:56:12Z"},{"alias_kind":"arxiv_version","alias_value":"1812.05623v1","created_at":"2026-05-17T23:56:12Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1812.05623","created_at":"2026-05-17T23:56:12Z"},{"alias_kind":"pith_short_12","alias_value":"6MYL2ENYPQX2","created_at":"2026-05-18T12:32:11Z"},{"alias_kind":"pith_short_16","alias_value":"6MYL2ENYPQX2K4IQ","created_at":"2026-05-18T12:32:11Z"},{"alias_kind":"pith_short_8","alias_value":"6MYL2ENY","created_at":"2026-05-18T12:32:11Z"}],"graph_snapshots":[{"event_id":"sha256:e5abab7e2b9959cc31f353f458bdca87a0d20ef2f9cf031686e2d567fe23e48c","target":"graph","created_at":"2026-05-17T23:56:12Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Cell growth is determined by substrate availability and the cell's metabolic capacity to assimilate substrates into building blocks. Metabolic genes that determine growth rate may interact synergistically or antagonistically, and can accelerate or slow growth, depending on the genetic background and environmental conditions. We evolved a diverse set of Escherichia coli single-gene deletion mutants with a spectrum of growth rates and identified mutations that generally increase growth rate. Despite the metabolic differences between parent strains, mutations that enhanced growth largely mapped t","authors_text":"Adilson E. Motter, Aleksandra Fergin, Aretha Fiebig, Jonathan W. Willett, Julien Herrou, Sean Crosson, Thomas P. Wytock","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2018-12-13T19:00:02Z","title":"Experimental evolution of diverse Escherichia coli metabolic mutants identifies genetic loci for convergent adaptation of growth rate"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1812.05623","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9c1db9869207d0562a455fc7d18df6961b5f680aab3029996aef893465229cb7","target":"record","created_at":"2026-05-17T23:56:12Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"93e0cd87f0713e8acdc5a36065f2faaf67edcad3ec9c8f8617801411f99d1d94","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2018-12-13T19:00:02Z","title_canon_sha256":"ba79f1fb3575bbf6556e017ec1766c0a402ee296c35c3720f1126fddefc2e1af"},"schema_version":"1.0","source":{"id":"1812.05623","kind":"arxiv","version":1}},"canonical_sha256":"f330bd11b87c2fa571109a515d311961ba618aa1850ab7a440e70d49347d3740","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f330bd11b87c2fa571109a515d311961ba618aa1850ab7a440e70d49347d3740","first_computed_at":"2026-05-17T23:56:12.446112Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:56:12.446112Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"6Bm7LZ8RI61BZPAPglEw/X//oWZimalHzRdn9jRkkX90J35816d8jlBIc7j7dBHh2IPbqRcm2eSzvEX1afnGAw==","signature_status":"signed_v1","signed_at":"2026-05-17T23:56:12.446783Z","signed_message":"canonical_sha256_bytes"},"source_id":"1812.05623","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9c1db9869207d0562a455fc7d18df6961b5f680aab3029996aef893465229cb7","sha256:e5abab7e2b9959cc31f353f458bdca87a0d20ef2f9cf031686e2d567fe23e48c"],"state_sha256":"31005691b142e799c0ce928b5ed1cebc4b85b8ab83bf57113cd3e4c7d3854eb4"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ps9smvasb7fEsNGdLWZ2qumFKgq4EFVA2vqRbTvpEzF4/CCtxOV0hJw3+2NriBtcRQz0EqamwStnp4xM0bXtBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-09T17:37:09.023894Z","bundle_sha256":"ba037b2937f7fb8a0505ad2b4e09e84347a72de8c50a052e2cff1ce359361edc"}}