{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2023:6QPN5SABNADNPWNMZQDIGJLJJY","short_pith_number":"pith:6QPN5SAB","schema_version":"1.0","canonical_sha256":"f41edec8016806d7d9accc068325694e1b77113f928d2e812d6a28570aa55d65","source":{"kind":"arxiv","id":"2302.11769","version":1},"attestation_state":"computed","paper":{"title":"Mid-infrared Chemical Imaging of Intracellular Tau Fibrils using Fluorescence-guided Computational Photothermal Microscopy","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"physics.optics","authors_text":"Alex Matlock, Benjamin Wolozin, Hongbo Zhu, Jiabei Zhu, Jian Zhao, Ji-Xin Cheng, Lei Tian, Lulu Jiang, Yihong Xu","submitted_at":"2023-02-23T04:20:10Z","abstract_excerpt":"Amyloid proteins are associated with a broad spectrum of neurodegenerative diseases. However, it remains a grand challenge to extract molecular structure information from intracellular amyloid proteins in their native cellular environment. To address this challenge, we developed a computational chemical microscope integrating 3D mid-infrared photothermal imaging with fluorescence imaging, termed Fluorescence-guided Bond-Selective Intensity Diffraction Tomography (FBS-IDT). Based on a low-cost and simple optical design, FBS-IDT enables chemical-specific volumetric imaging and 3D site-specific m"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2302.11769","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.optics","submitted_at":"2023-02-23T04:20:10Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"79101172c7b8e3e552855776f569c424bdd56e0cfc68ecbe60f3ddc40b1aef64","abstract_canon_sha256":"bd2c2780fda1f87d45a8799902b71ee30f0572306204a40063f3108fb629015c"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T05:44:55.984806Z","signature_b64":"8b8FbXNRZv9F8Uv4NkiCzuMDnIePeF/A/4YwJWuzL/FWVOYBwvqnOwEVnnjlpTXHQOe4aZyY+sSJ+ZQin4/LDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f41edec8016806d7d9accc068325694e1b77113f928d2e812d6a28570aa55d65","last_reissued_at":"2026-07-05T05:44:55.984388Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T05:44:55.984388Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Mid-infrared Chemical Imaging of Intracellular Tau Fibrils using Fluorescence-guided Computational Photothermal Microscopy","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"physics.optics","authors_text":"Alex Matlock, Benjamin Wolozin, Hongbo Zhu, Jiabei Zhu, Jian Zhao, Ji-Xin Cheng, Lei Tian, Lulu Jiang, Yihong Xu","submitted_at":"2023-02-23T04:20:10Z","abstract_excerpt":"Amyloid proteins are associated with a broad spectrum of neurodegenerative diseases. However, it remains a grand challenge to extract molecular structure information from intracellular amyloid proteins in their native cellular environment. To address this challenge, we developed a computational chemical microscope integrating 3D mid-infrared photothermal imaging with fluorescence imaging, termed Fluorescence-guided Bond-Selective Intensity Diffraction Tomography (FBS-IDT). Based on a low-cost and simple optical design, FBS-IDT enables chemical-specific volumetric imaging and 3D site-specific m"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2302.11769","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2302.11769/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2302.11769","created_at":"2026-07-05T05:44:55.984443+00:00"},{"alias_kind":"arxiv_version","alias_value":"2302.11769v1","created_at":"2026-07-05T05:44:55.984443+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2302.11769","created_at":"2026-07-05T05:44:55.984443+00:00"},{"alias_kind":"pith_short_12","alias_value":"6QPN5SABNADN","created_at":"2026-07-05T05:44:55.984443+00:00"},{"alias_kind":"pith_short_16","alias_value":"6QPN5SABNADNPWNM","created_at":"2026-07-05T05:44:55.984443+00:00"},{"alias_kind":"pith_short_8","alias_value":"6QPN5SAB","created_at":"2026-07-05T05:44:55.984443+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/6QPN5SABNADNPWNMZQDIGJLJJY","json":"https://pith.science/pith/6QPN5SABNADNPWNMZQDIGJLJJY.json","graph_json":"https://pith.science/api/pith-number/6QPN5SABNADNPWNMZQDIGJLJJY/graph.json","events_json":"https://pith.science/api/pith-number/6QPN5SABNADNPWNMZQDIGJLJJY/events.json","paper":"https://pith.science/paper/6QPN5SAB"},"agent_actions":{"view_html":"https://pith.science/pith/6QPN5SABNADNPWNMZQDIGJLJJY","download_json":"https://pith.science/pith/6QPN5SABNADNPWNMZQDIGJLJJY.json","view_paper":"https://pith.science/paper/6QPN5SAB","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2302.11769&json=true","fetch_graph":"https://pith.science/api/pith-number/6QPN5SABNADNPWNMZQDIGJLJJY/graph.json","fetch_events":"https://pith.science/api/pith-number/6QPN5SABNADNPWNMZQDIGJLJJY/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/6QPN5SABNADNPWNMZQDIGJLJJY/action/timestamp_anchor","attest_storage":"https://pith.science/pith/6QPN5SABNADNPWNMZQDIGJLJJY/action/storage_attestation","attest_author":"https://pith.science/pith/6QPN5SABNADNPWNMZQDIGJLJJY/action/author_attestation","sign_citation":"https://pith.science/pith/6QPN5SABNADNPWNMZQDIGJLJJY/action/citation_signature","submit_replication":"https://pith.science/pith/6QPN5SABNADNPWNMZQDIGJLJJY/action/replication_record"}},"created_at":"2026-07-05T05:44:55.984443+00:00","updated_at":"2026-07-05T05:44:55.984443+00:00"}