{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:6R2T5L7447S5OTHVO3WY2554TH","short_pith_number":"pith:6R2T5L74","canonical_record":{"source":{"id":"1901.06431","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2019-01-18T22:12:39Z","cross_cats_sorted":[],"title_canon_sha256":"05a02c2539f605b8d0794d3e8e078944c2384b87eddbedbbb1c7c9c66bdae4fb","abstract_canon_sha256":"c2f90632e963ae118187024e191c7cc8f95fff2914a79900119d672c4227804f"},"schema_version":"1.0"},"canonical_sha256":"f4753eaffce7e5d74cf576ed8d77bc99fd5375cc8fa54e7266f76650a4552351","source":{"kind":"arxiv","id":"1901.06431","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1901.06431","created_at":"2026-05-17T23:40:17Z"},{"alias_kind":"arxiv_version","alias_value":"1901.06431v2","created_at":"2026-05-17T23:40:17Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1901.06431","created_at":"2026-05-17T23:40:17Z"},{"alias_kind":"pith_short_12","alias_value":"6R2T5L7447S5","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_16","alias_value":"6R2T5L7447S5OTHV","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_8","alias_value":"6R2T5L74","created_at":"2026-05-18T12:33:10Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:6R2T5L7447S5OTHVO3WY2554TH","target":"record","payload":{"canonical_record":{"source":{"id":"1901.06431","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2019-01-18T22:12:39Z","cross_cats_sorted":[],"title_canon_sha256":"05a02c2539f605b8d0794d3e8e078944c2384b87eddbedbbb1c7c9c66bdae4fb","abstract_canon_sha256":"c2f90632e963ae118187024e191c7cc8f95fff2914a79900119d672c4227804f"},"schema_version":"1.0"},"canonical_sha256":"f4753eaffce7e5d74cf576ed8d77bc99fd5375cc8fa54e7266f76650a4552351","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:40:17.609977Z","signature_b64":"9VKWf0zUY5QjnGvx0Cpohhsu/Lr+POhNj+LI1E1NDBdya5QK6tcmbGS0Zca2g5rsQMCabCEQI21jPFZT0WcfDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f4753eaffce7e5d74cf576ed8d77bc99fd5375cc8fa54e7266f76650a4552351","last_reissued_at":"2026-05-17T23:40:17.609267Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:40:17.609267Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1901.06431","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:40:17Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"KgvtVlAW3xzKafjeeiWRmBev+x5Q6oGEdH631I1b5SoQCy7t/8sCysany0RmDGyKubN5pcdGPnH4trx5JkWaAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T03:52:02.690147Z"},"content_sha256":"b9a2c09c299bcd5a5a49e32d728d9f64743475f616880bab844205ffdca25cfe","schema_version":"1.0","event_id":"sha256:b9a2c09c299bcd5a5a49e32d728d9f64743475f616880bab844205ffdca25cfe"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:6R2T5L7447S5OTHVO3WY2554TH","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Vagal contributions to fetal heart rate variability: an omics approach","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.QM","authors_text":"Andre Desrochers, Andrew JE Seely, Christophe L. Herry, Gilles Fecteau, Lucien Daniel Durosier, Martin G. Frasch, Mingju Cao, Patrick Burns","submitted_at":"2019-01-18T22:12:39Z","abstract_excerpt":"Fetal heart rate variability (fHRV) is an important indicator of health and disease, yet its physiological origins, neural contributions in particular, are not well understood. We aimed to develop novel experimental and data analytical approaches to identify fHRV measures reflecting the vagus nerve contributions to fHRV. In near-term ovine fetuses, a comprehensive set of 46 fHRV measures was computed from fetal pre-cordial electrocardiogram recorded during surgery and 72 hours later without (n=24) and with intra-surgical bilateral cervical vagotomy (n=15). The fetal heart rate did not change d"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1901.06431","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:40:17Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"p00WFmyArn58f+4G62fzDZa7hafiz5hI6eWmF5c7lLrWw+T7tDtPG1B5pySVWGd4lQY8MIau2OacVmU22i61Bw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-05T03:52:02.690764Z"},"content_sha256":"f3c38fe830dcd0f034ad16bb2299aaa1aefd959530fb8daa91a65ad1056b3f3c","schema_version":"1.0","event_id":"sha256:f3c38fe830dcd0f034ad16bb2299aaa1aefd959530fb8daa91a65ad1056b3f3c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/6R2T5L7447S5OTHVO3WY2554TH/bundle.json","state_url":"https://pith.science/pith/6R2T5L7447S5OTHVO3WY2554TH/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/6R2T5L7447S5OTHVO3WY2554TH/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-05T03:52:02Z","links":{"resolver":"https://pith.science/pith/6R2T5L7447S5OTHVO3WY2554TH","bundle":"https://pith.science/pith/6R2T5L7447S5OTHVO3WY2554TH/bundle.json","state":"https://pith.science/pith/6R2T5L7447S5OTHVO3WY2554TH/state.json","well_known_bundle":"https://pith.science/.well-known/pith/6R2T5L7447S5OTHVO3WY2554TH/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:6R2T5L7447S5OTHVO3WY2554TH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c2f90632e963ae118187024e191c7cc8f95fff2914a79900119d672c4227804f","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2019-01-18T22:12:39Z","title_canon_sha256":"05a02c2539f605b8d0794d3e8e078944c2384b87eddbedbbb1c7c9c66bdae4fb"},"schema_version":"1.0","source":{"id":"1901.06431","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1901.06431","created_at":"2026-05-17T23:40:17Z"},{"alias_kind":"arxiv_version","alias_value":"1901.06431v2","created_at":"2026-05-17T23:40:17Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1901.06431","created_at":"2026-05-17T23:40:17Z"},{"alias_kind":"pith_short_12","alias_value":"6R2T5L7447S5","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_16","alias_value":"6R2T5L7447S5OTHV","created_at":"2026-05-18T12:33:10Z"},{"alias_kind":"pith_short_8","alias_value":"6R2T5L74","created_at":"2026-05-18T12:33:10Z"}],"graph_snapshots":[{"event_id":"sha256:f3c38fe830dcd0f034ad16bb2299aaa1aefd959530fb8daa91a65ad1056b3f3c","target":"graph","created_at":"2026-05-17T23:40:17Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Fetal heart rate variability (fHRV) is an important indicator of health and disease, yet its physiological origins, neural contributions in particular, are not well understood. We aimed to develop novel experimental and data analytical approaches to identify fHRV measures reflecting the vagus nerve contributions to fHRV. In near-term ovine fetuses, a comprehensive set of 46 fHRV measures was computed from fetal pre-cordial electrocardiogram recorded during surgery and 72 hours later without (n=24) and with intra-surgical bilateral cervical vagotomy (n=15). The fetal heart rate did not change d","authors_text":"Andre Desrochers, Andrew JE Seely, Christophe L. Herry, Gilles Fecteau, Lucien Daniel Durosier, Martin G. Frasch, Mingju Cao, Patrick Burns","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2019-01-18T22:12:39Z","title":"Vagal contributions to fetal heart rate variability: an omics approach"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1901.06431","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b9a2c09c299bcd5a5a49e32d728d9f64743475f616880bab844205ffdca25cfe","target":"record","created_at":"2026-05-17T23:40:17Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c2f90632e963ae118187024e191c7cc8f95fff2914a79900119d672c4227804f","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.QM","submitted_at":"2019-01-18T22:12:39Z","title_canon_sha256":"05a02c2539f605b8d0794d3e8e078944c2384b87eddbedbbb1c7c9c66bdae4fb"},"schema_version":"1.0","source":{"id":"1901.06431","kind":"arxiv","version":2}},"canonical_sha256":"f4753eaffce7e5d74cf576ed8d77bc99fd5375cc8fa54e7266f76650a4552351","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f4753eaffce7e5d74cf576ed8d77bc99fd5375cc8fa54e7266f76650a4552351","first_computed_at":"2026-05-17T23:40:17.609267Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:40:17.609267Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"9VKWf0zUY5QjnGvx0Cpohhsu/Lr+POhNj+LI1E1NDBdya5QK6tcmbGS0Zca2g5rsQMCabCEQI21jPFZT0WcfDA==","signature_status":"signed_v1","signed_at":"2026-05-17T23:40:17.609977Z","signed_message":"canonical_sha256_bytes"},"source_id":"1901.06431","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b9a2c09c299bcd5a5a49e32d728d9f64743475f616880bab844205ffdca25cfe","sha256:f3c38fe830dcd0f034ad16bb2299aaa1aefd959530fb8daa91a65ad1056b3f3c"],"state_sha256":"0fe7488aa0bd1bf00a938bf5bdaa837052eb763ed431d74b308a05d2166732e5"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TAi1p2ZpJ68SfOKfl4+01lD6RkloDpnW7TUduRJL1bAvSh90AXHNv8oF4bVdtR5F4KHFD34jbnOxruC7989QCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-05T03:52:02.695069Z","bundle_sha256":"55ce89f7d077e3f44743d2a5256cd7b20b954e8c08bf7f20b0c60f806d361c96"}}