{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2012:6SR4MDMWLB7SMZ4VPTZFMUAG7L","short_pith_number":"pith:6SR4MDMW","schema_version":"1.0","canonical_sha256":"f4a3c60d96587f2667957cf2565006faf5770ed2851b324f06d7042a23b16760","source":{"kind":"arxiv","id":"1210.2850","version":1},"attestation_state":"computed","paper":{"title":"A mixed model approach for joint genetic analysis of alternatively spliced transcript isoforms using RNA-Seq data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.PE","q-bio.QM"],"primary_cat":"q-bio.GN","authors_text":"Antti Honkela, Barbara Rakitsch, Christoph Lippert, Hande Topa, Karsten Borgwardt, Oliver Stegle","submitted_at":"2012-10-10T09:56:06Z","abstract_excerpt":"RNA-Seq technology allows for studying the transcriptional state of the cell at an unprecedented level of detail. Beyond quantification of whole-gene expression, it is now possible to disentangle the abundance of individual alternatively spliced transcript isoforms of a gene. A central question is to understand the regulatory processes that lead to differences in relative abundance variation due to external and genetic factors. Here, we present a mixed model approach that allows for (i) joint analysis and genetic mapping of multiple transcript isoforms and (ii) mapping of isoform-specific effe"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1210.2850","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-10-10T09:56:06Z","cross_cats_sorted":["q-bio.PE","q-bio.QM"],"title_canon_sha256":"2d1c828c572e6b99e6776808f9491556a283e6b1a0d59a64546a67e4b59b655c","abstract_canon_sha256":"e8082422c27542365714a0af78675a356f460a3a8349febedc78ea6a6ac3864d"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:43:31.374224Z","signature_b64":"SGd7Y/KcFVRQbor9CIaHMnkTx4CzI/Ajfh/et3UvCEu7MuRPNPRGLZKVtAufZNb6JLW/jS8JJGIieHQYsN14Bg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f4a3c60d96587f2667957cf2565006faf5770ed2851b324f06d7042a23b16760","last_reissued_at":"2026-05-18T03:43:31.373462Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:43:31.373462Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"A mixed model approach for joint genetic analysis of alternatively spliced transcript isoforms using RNA-Seq data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.PE","q-bio.QM"],"primary_cat":"q-bio.GN","authors_text":"Antti Honkela, Barbara Rakitsch, Christoph Lippert, Hande Topa, Karsten Borgwardt, Oliver Stegle","submitted_at":"2012-10-10T09:56:06Z","abstract_excerpt":"RNA-Seq technology allows for studying the transcriptional state of the cell at an unprecedented level of detail. Beyond quantification of whole-gene expression, it is now possible to disentangle the abundance of individual alternatively spliced transcript isoforms of a gene. A central question is to understand the regulatory processes that lead to differences in relative abundance variation due to external and genetic factors. Here, we present a mixed model approach that allows for (i) joint analysis and genetic mapping of multiple transcript isoforms and (ii) mapping of isoform-specific effe"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1210.2850","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1210.2850","created_at":"2026-05-18T03:43:31.373580+00:00"},{"alias_kind":"arxiv_version","alias_value":"1210.2850v1","created_at":"2026-05-18T03:43:31.373580+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1210.2850","created_at":"2026-05-18T03:43:31.373580+00:00"},{"alias_kind":"pith_short_12","alias_value":"6SR4MDMWLB7S","created_at":"2026-05-18T12:26:56.085431+00:00"},{"alias_kind":"pith_short_16","alias_value":"6SR4MDMWLB7SMZ4V","created_at":"2026-05-18T12:26:56.085431+00:00"},{"alias_kind":"pith_short_8","alias_value":"6SR4MDMW","created_at":"2026-05-18T12:26:56.085431+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/6SR4MDMWLB7SMZ4VPTZFMUAG7L","json":"https://pith.science/pith/6SR4MDMWLB7SMZ4VPTZFMUAG7L.json","graph_json":"https://pith.science/api/pith-number/6SR4MDMWLB7SMZ4VPTZFMUAG7L/graph.json","events_json":"https://pith.science/api/pith-number/6SR4MDMWLB7SMZ4VPTZFMUAG7L/events.json","paper":"https://pith.science/paper/6SR4MDMW"},"agent_actions":{"view_html":"https://pith.science/pith/6SR4MDMWLB7SMZ4VPTZFMUAG7L","download_json":"https://pith.science/pith/6SR4MDMWLB7SMZ4VPTZFMUAG7L.json","view_paper":"https://pith.science/paper/6SR4MDMW","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1210.2850&json=true","fetch_graph":"https://pith.science/api/pith-number/6SR4MDMWLB7SMZ4VPTZFMUAG7L/graph.json","fetch_events":"https://pith.science/api/pith-number/6SR4MDMWLB7SMZ4VPTZFMUAG7L/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/6SR4MDMWLB7SMZ4VPTZFMUAG7L/action/timestamp_anchor","attest_storage":"https://pith.science/pith/6SR4MDMWLB7SMZ4VPTZFMUAG7L/action/storage_attestation","attest_author":"https://pith.science/pith/6SR4MDMWLB7SMZ4VPTZFMUAG7L/action/author_attestation","sign_citation":"https://pith.science/pith/6SR4MDMWLB7SMZ4VPTZFMUAG7L/action/citation_signature","submit_replication":"https://pith.science/pith/6SR4MDMWLB7SMZ4VPTZFMUAG7L/action/replication_record"}},"created_at":"2026-05-18T03:43:31.373580+00:00","updated_at":"2026-05-18T03:43:31.373580+00:00"}