{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:6VEVBIQTNQTBW5TLAS2RMV66YH","short_pith_number":"pith:6VEVBIQT","canonical_record":{"source":{"id":"1511.00171","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-10-31T20:51:11Z","cross_cats_sorted":["q-bio.MN","q-bio.SC"],"title_canon_sha256":"3e08999a7c774486f879aa1a7771a2249c9ad2881379a2b57a611c5639729f8d","abstract_canon_sha256":"56239062dff85ae6dcda8b034a8ddf21fb16b981c8a018683785c4abfce11061"},"schema_version":"1.0"},"canonical_sha256":"f54950a2136c261b766b04b51657dec1d5158cfd8b678f58e4a172ba07225bc2","source":{"kind":"arxiv","id":"1511.00171","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1511.00171","created_at":"2026-05-18T01:22:19Z"},{"alias_kind":"arxiv_version","alias_value":"1511.00171v1","created_at":"2026-05-18T01:22:19Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1511.00171","created_at":"2026-05-18T01:22:19Z"},{"alias_kind":"pith_short_12","alias_value":"6VEVBIQTNQTB","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_16","alias_value":"6VEVBIQTNQTBW5TL","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_8","alias_value":"6VEVBIQT","created_at":"2026-05-18T12:29:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:6VEVBIQTNQTBW5TLAS2RMV66YH","target":"record","payload":{"canonical_record":{"source":{"id":"1511.00171","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-10-31T20:51:11Z","cross_cats_sorted":["q-bio.MN","q-bio.SC"],"title_canon_sha256":"3e08999a7c774486f879aa1a7771a2249c9ad2881379a2b57a611c5639729f8d","abstract_canon_sha256":"56239062dff85ae6dcda8b034a8ddf21fb16b981c8a018683785c4abfce11061"},"schema_version":"1.0"},"canonical_sha256":"f54950a2136c261b766b04b51657dec1d5158cfd8b678f58e4a172ba07225bc2","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:22:19.751760Z","signature_b64":"lSuzm0F04GmWVIsCI3cCpQpbxoLzfwmpY78kaZUp7y5H2ZQLsT/XzTUc6jEhaSJV4G9jSuCksmhH9bxgnclDAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f54950a2136c261b766b04b51657dec1d5158cfd8b678f58e4a172ba07225bc2","last_reissued_at":"2026-05-18T01:22:19.750955Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:22:19.750955Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1511.00171","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:22:19Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"0ngwTR4BC9L//fnX7KJmhGeRUvSaGlxOnUdgY7QG0iYKd2RJU6vTI/A2NnXyVm5wqYgEE3QyTHO7ymoDLK8RAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T16:12:19.200244Z"},"content_sha256":"e2fb21e8ceb2599928981f0320c8cad4a4431b482d554fb49b04348816f4f782","schema_version":"1.0","event_id":"sha256:e2fb21e8ceb2599928981f0320c8cad4a4431b482d554fb49b04348816f4f782"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:6VEVBIQTNQTBW5TLAS2RMV66YH","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Know the single-receptor sensing limit? Think again","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN","q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"Gerardo Aquino, Ned S. Wingreen, Robert G. Endres","submitted_at":"2015-10-31T20:51:11Z","abstract_excerpt":"How cells reliably infer information about their environment is a fundamentally important question. While sensing and signaling generally start with cell-surface receptors, the degree of accuracy with which a cell can measure external ligand concentration with even the simplest device - a single receptor - is surprisingly hard to pin down. Recent studies provide conflicting results for the fundamental physical limits. Comparison is made difficult as different studies either suggest different readout mechanisms of the ligand-receptor occupancy, or differ on how ligand diffusion is implemented. "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1511.00171","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:22:19Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"uVhVtm+TbKJLTxTBzo35l7TKX2CSG9OYBMG0p8og9ojElxtMkTD3XoHWRn7/VQN8kZQlop0eKJ4gzOOkHkfiCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T16:12:19.200603Z"},"content_sha256":"e01dc2e72039ab8c73c37c4438cd1ebc3ea1c6666bc36febe79d0afd8175947b","schema_version":"1.0","event_id":"sha256:e01dc2e72039ab8c73c37c4438cd1ebc3ea1c6666bc36febe79d0afd8175947b"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/6VEVBIQTNQTBW5TLAS2RMV66YH/bundle.json","state_url":"https://pith.science/pith/6VEVBIQTNQTBW5TLAS2RMV66YH/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/6VEVBIQTNQTBW5TLAS2RMV66YH/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-03T16:12:19Z","links":{"resolver":"https://pith.science/pith/6VEVBIQTNQTBW5TLAS2RMV66YH","bundle":"https://pith.science/pith/6VEVBIQTNQTBW5TLAS2RMV66YH/bundle.json","state":"https://pith.science/pith/6VEVBIQTNQTBW5TLAS2RMV66YH/state.json","well_known_bundle":"https://pith.science/.well-known/pith/6VEVBIQTNQTBW5TLAS2RMV66YH/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:6VEVBIQTNQTBW5TLAS2RMV66YH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"56239062dff85ae6dcda8b034a8ddf21fb16b981c8a018683785c4abfce11061","cross_cats_sorted":["q-bio.MN","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-10-31T20:51:11Z","title_canon_sha256":"3e08999a7c774486f879aa1a7771a2249c9ad2881379a2b57a611c5639729f8d"},"schema_version":"1.0","source":{"id":"1511.00171","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1511.00171","created_at":"2026-05-18T01:22:19Z"},{"alias_kind":"arxiv_version","alias_value":"1511.00171v1","created_at":"2026-05-18T01:22:19Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1511.00171","created_at":"2026-05-18T01:22:19Z"},{"alias_kind":"pith_short_12","alias_value":"6VEVBIQTNQTB","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_16","alias_value":"6VEVBIQTNQTBW5TL","created_at":"2026-05-18T12:29:07Z"},{"alias_kind":"pith_short_8","alias_value":"6VEVBIQT","created_at":"2026-05-18T12:29:07Z"}],"graph_snapshots":[{"event_id":"sha256:e01dc2e72039ab8c73c37c4438cd1ebc3ea1c6666bc36febe79d0afd8175947b","target":"graph","created_at":"2026-05-18T01:22:19Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"How cells reliably infer information about their environment is a fundamentally important question. While sensing and signaling generally start with cell-surface receptors, the degree of accuracy with which a cell can measure external ligand concentration with even the simplest device - a single receptor - is surprisingly hard to pin down. Recent studies provide conflicting results for the fundamental physical limits. Comparison is made difficult as different studies either suggest different readout mechanisms of the ligand-receptor occupancy, or differ on how ligand diffusion is implemented. ","authors_text":"Gerardo Aquino, Ned S. Wingreen, Robert G. Endres","cross_cats":["q-bio.MN","q-bio.SC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-10-31T20:51:11Z","title":"Know the single-receptor sensing limit? Think again"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1511.00171","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e2fb21e8ceb2599928981f0320c8cad4a4431b482d554fb49b04348816f4f782","target":"record","created_at":"2026-05-18T01:22:19Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"56239062dff85ae6dcda8b034a8ddf21fb16b981c8a018683785c4abfce11061","cross_cats_sorted":["q-bio.MN","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-10-31T20:51:11Z","title_canon_sha256":"3e08999a7c774486f879aa1a7771a2249c9ad2881379a2b57a611c5639729f8d"},"schema_version":"1.0","source":{"id":"1511.00171","kind":"arxiv","version":1}},"canonical_sha256":"f54950a2136c261b766b04b51657dec1d5158cfd8b678f58e4a172ba07225bc2","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f54950a2136c261b766b04b51657dec1d5158cfd8b678f58e4a172ba07225bc2","first_computed_at":"2026-05-18T01:22:19.750955Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:22:19.750955Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"lSuzm0F04GmWVIsCI3cCpQpbxoLzfwmpY78kaZUp7y5H2ZQLsT/XzTUc6jEhaSJV4G9jSuCksmhH9bxgnclDAw==","signature_status":"signed_v1","signed_at":"2026-05-18T01:22:19.751760Z","signed_message":"canonical_sha256_bytes"},"source_id":"1511.00171","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e2fb21e8ceb2599928981f0320c8cad4a4431b482d554fb49b04348816f4f782","sha256:e01dc2e72039ab8c73c37c4438cd1ebc3ea1c6666bc36febe79d0afd8175947b"],"state_sha256":"80dbe743d94d23c2c2c3ced1f08d6b8f50287268a4c7d8fc0a0847351592599a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"KF+GjCLR8/iw+QQ1XJCPxrEGdhcTC+a7Twbxz/+7D0pf6MW1yeNKWoTFc4UqIY2kvl7tsUjlXBOR76cBJOlUDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-03T16:12:19.202487Z","bundle_sha256":"a69f686556daac2ec9456e6957dc8cc1e557d66911ceffd21e533cae62e0a39f"}}