{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:6VKXRS7NWPJBBYMRRRA227N37E","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6f8d1e07d382f4e7a12de81c278f311d5382c5a57fcc93aa0ee2fab3b55d4ead","cross_cats_sorted":["stat.AP"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"stat.ME","submitted_at":"2024-12-04T11:47:12Z","title_canon_sha256":"f28d0043baeb82ec97c0662ca47d92b6543c73d23e3d023f3369c7e8ae55e3bd"},"schema_version":"1.0","source":{"id":"2412.03246","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2412.03246","created_at":"2026-06-08T01:03:42Z"},{"alias_kind":"arxiv_version","alias_value":"2412.03246v2","created_at":"2026-06-08T01:03:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2412.03246","created_at":"2026-06-08T01:03:42Z"},{"alias_kind":"pith_short_12","alias_value":"6VKXRS7NWPJB","created_at":"2026-06-08T01:03:42Z"},{"alias_kind":"pith_short_16","alias_value":"6VKXRS7NWPJBBYMR","created_at":"2026-06-08T01:03:42Z"},{"alias_kind":"pith_short_8","alias_value":"6VKXRS7N","created_at":"2026-06-08T01:03:42Z"}],"graph_snapshots":[{"event_id":"sha256:a65c2dd499464151486a53dab47c235198ddb00a739131e9f9e4b2ee8110951a","target":"graph","created_at":"2026-06-08T01:03:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2412.03246/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"In clinical trials with recurrent events, such as repeated hospitalizations terminating with death, it is important to consider the patient events overall history for a thorough assessment of treatment effects. The occurrence of fewer events due to early deaths can lead to misinterpretation, emphasizing the importance of a while-alive strategy as suggested in Schmidli et al. (2023). In this study, we focus on the patient weighted while-alive estimand, represented as the expected number of events divided by the time alive within a target window, and develop efficient estimation for this estiman","authors_text":"Alessandra Ragni, Thomas Scheike, Torben Martinussen","cross_cats":["stat.AP"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"stat.ME","submitted_at":"2024-12-04T11:47:12Z","title":"Nonparametric estimation of the Patient Weighted While-Alive Estimand"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2412.03246","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:36a8f5fa66f24d90842fb6fbccdc2adf2379dd60d3e3c1f51ab607f3bef0e630","target":"record","created_at":"2026-06-08T01:03:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6f8d1e07d382f4e7a12de81c278f311d5382c5a57fcc93aa0ee2fab3b55d4ead","cross_cats_sorted":["stat.AP"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"stat.ME","submitted_at":"2024-12-04T11:47:12Z","title_canon_sha256":"f28d0043baeb82ec97c0662ca47d92b6543c73d23e3d023f3369c7e8ae55e3bd"},"schema_version":"1.0","source":{"id":"2412.03246","kind":"arxiv","version":2}},"canonical_sha256":"f55578cbedb3d210e1918c41ad7dbbf929eceb2a8fecfb03f29a78336792f12d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f55578cbedb3d210e1918c41ad7dbbf929eceb2a8fecfb03f29a78336792f12d","first_computed_at":"2026-06-08T01:03:42.499888Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-08T01:03:42.499888Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"QxdTmIMMmHqsUBFWYpbOov4JvNbDDH1XN1uSJcGfrCotFbzxS1lQmRRkDuZmKDRMhg1iDPGXSMhP8BPRAJ1gDg==","signature_status":"signed_v1","signed_at":"2026-06-08T01:03:42.500954Z","signed_message":"canonical_sha256_bytes"},"source_id":"2412.03246","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:36a8f5fa66f24d90842fb6fbccdc2adf2379dd60d3e3c1f51ab607f3bef0e630","sha256:a65c2dd499464151486a53dab47c235198ddb00a739131e9f9e4b2ee8110951a"],"state_sha256":"f7681413c8f2566d4b00a60b59019d7758deeb7d8e7a2b6e8c0bd733d8696e93"}