{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:6WVAUWNKLSNUIO4ZSXRI2W4B5N","short_pith_number":"pith:6WVAUWNK","canonical_record":{"source":{"id":"1908.05370","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2019-08-14T23:05:08Z","cross_cats_sorted":[],"title_canon_sha256":"f578a241af67bd9d4b9dbc836e0a734ed5f1cb082cd76951381787467bfa0d91","abstract_canon_sha256":"ab39173678c3e0cb2fee679e52caed69cf0fad78531aeb377b2ce298098a0b95"},"schema_version":"1.0"},"canonical_sha256":"f5aa0a59aa5c9b443b9995e28d5b81eb6bf7bd47d3c03db129cbaccf96082faa","source":{"kind":"arxiv","id":"1908.05370","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1908.05370","created_at":"2026-07-04T23:56:50Z"},{"alias_kind":"arxiv_version","alias_value":"1908.05370v1","created_at":"2026-07-04T23:56:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1908.05370","created_at":"2026-07-04T23:56:50Z"},{"alias_kind":"pith_short_12","alias_value":"6WVAUWNKLSNU","created_at":"2026-07-04T23:56:50Z"},{"alias_kind":"pith_short_16","alias_value":"6WVAUWNKLSNUIO4Z","created_at":"2026-07-04T23:56:50Z"},{"alias_kind":"pith_short_8","alias_value":"6WVAUWNK","created_at":"2026-07-04T23:56:50Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:6WVAUWNKLSNUIO4ZSXRI2W4B5N","target":"record","payload":{"canonical_record":{"source":{"id":"1908.05370","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2019-08-14T23:05:08Z","cross_cats_sorted":[],"title_canon_sha256":"f578a241af67bd9d4b9dbc836e0a734ed5f1cb082cd76951381787467bfa0d91","abstract_canon_sha256":"ab39173678c3e0cb2fee679e52caed69cf0fad78531aeb377b2ce298098a0b95"},"schema_version":"1.0"},"canonical_sha256":"f5aa0a59aa5c9b443b9995e28d5b81eb6bf7bd47d3c03db129cbaccf96082faa","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-04T23:56:50.897096Z","signature_b64":"KiV8bRdeeaKmgvLNjxGUot7/0B9fDbwJ0Yyo7O17s6GEWbPmeXEoH7rzFcdaayozld9uUvt9h1lG0ql9shTUAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f5aa0a59aa5c9b443b9995e28d5b81eb6bf7bd47d3c03db129cbaccf96082faa","last_reissued_at":"2026-07-04T23:56:50.896726Z","signature_status":"signed_v1","first_computed_at":"2026-07-04T23:56:50.896726Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1908.05370","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-04T23:56:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"bQ9xwlXY6hIUHnRwZQqxKiek87hxfRaiDzp8clRNLADjklpbLHPGdq3v0MD8Yx2fD1o7CBJ/6vYi2KvdNdjsBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-16T05:47:30.811868Z"},"content_sha256":"7ac55d59e29d3c65fd6ed8f5b2d88a7a45ed572f5a2ec11a1bed3092cb949f78","schema_version":"1.0","event_id":"sha256:7ac55d59e29d3c65fd6ed8f5b2d88a7a45ed572f5a2ec11a1bed3092cb949f78"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:6WVAUWNKLSNUIO4ZSXRI2W4B5N","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Laboratory biases hinder Eco-Evo-Devo integration: hints from the microworld","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Alejandra Hernandez-Teran, Ana E. Escalante, Mariana Benitez, Natsuko Rivera-Yoshida","submitted_at":"2019-08-14T23:05:08Z","abstract_excerpt":"How specific environmental contexts contribute to the robustness and variation of developmental trajectories and evolutionary transitions is a central point in Eco-Evo-Devo. However, the articulation of ecological, evolutionary and developmental processes into integrative frameworks has been elusive, partly because standard experimental designs neglect or oversimplify ecologically meaningful contexts. Microbial models are useful to expose and discuss two possible sources of bias associated with gene-centered experimental designs: the use of laboratory strains and laboratory environmental condi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1908.05370","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/1908.05370/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-04T23:56:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"6z8hSYQJ2W1xObiMNnFaD20RPicH+X5J5pAcNlZ3Fo8Hmz7ay1yb6LdEpzZV5AqfQx07ybshqnCB2s2uq4KLBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-16T05:47:30.812365Z"},"content_sha256":"efd669d8e08c269114b2a9f2f8db2b18ec518f8dbbfa324f2766c0f15d7271aa","schema_version":"1.0","event_id":"sha256:efd669d8e08c269114b2a9f2f8db2b18ec518f8dbbfa324f2766c0f15d7271aa"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/6WVAUWNKLSNUIO4ZSXRI2W4B5N/bundle.json","state_url":"https://pith.science/pith/6WVAUWNKLSNUIO4ZSXRI2W4B5N/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/6WVAUWNKLSNUIO4ZSXRI2W4B5N/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-16T05:47:30Z","links":{"resolver":"https://pith.science/pith/6WVAUWNKLSNUIO4ZSXRI2W4B5N","bundle":"https://pith.science/pith/6WVAUWNKLSNUIO4ZSXRI2W4B5N/bundle.json","state":"https://pith.science/pith/6WVAUWNKLSNUIO4ZSXRI2W4B5N/state.json","well_known_bundle":"https://pith.science/.well-known/pith/6WVAUWNKLSNUIO4ZSXRI2W4B5N/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:6WVAUWNKLSNUIO4ZSXRI2W4B5N","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ab39173678c3e0cb2fee679e52caed69cf0fad78531aeb377b2ce298098a0b95","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2019-08-14T23:05:08Z","title_canon_sha256":"f578a241af67bd9d4b9dbc836e0a734ed5f1cb082cd76951381787467bfa0d91"},"schema_version":"1.0","source":{"id":"1908.05370","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1908.05370","created_at":"2026-07-04T23:56:50Z"},{"alias_kind":"arxiv_version","alias_value":"1908.05370v1","created_at":"2026-07-04T23:56:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1908.05370","created_at":"2026-07-04T23:56:50Z"},{"alias_kind":"pith_short_12","alias_value":"6WVAUWNKLSNU","created_at":"2026-07-04T23:56:50Z"},{"alias_kind":"pith_short_16","alias_value":"6WVAUWNKLSNUIO4Z","created_at":"2026-07-04T23:56:50Z"},{"alias_kind":"pith_short_8","alias_value":"6WVAUWNK","created_at":"2026-07-04T23:56:50Z"}],"graph_snapshots":[{"event_id":"sha256:efd669d8e08c269114b2a9f2f8db2b18ec518f8dbbfa324f2766c0f15d7271aa","target":"graph","created_at":"2026-07-04T23:56:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/1908.05370/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"How specific environmental contexts contribute to the robustness and variation of developmental trajectories and evolutionary transitions is a central point in Eco-Evo-Devo. However, the articulation of ecological, evolutionary and developmental processes into integrative frameworks has been elusive, partly because standard experimental designs neglect or oversimplify ecologically meaningful contexts. Microbial models are useful to expose and discuss two possible sources of bias associated with gene-centered experimental designs: the use of laboratory strains and laboratory environmental condi","authors_text":"Alejandra Hernandez-Teran, Ana E. Escalante, Mariana Benitez, Natsuko Rivera-Yoshida","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2019-08-14T23:05:08Z","title":"Laboratory biases hinder Eco-Evo-Devo integration: hints from the microworld"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1908.05370","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:7ac55d59e29d3c65fd6ed8f5b2d88a7a45ed572f5a2ec11a1bed3092cb949f78","target":"record","created_at":"2026-07-04T23:56:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ab39173678c3e0cb2fee679e52caed69cf0fad78531aeb377b2ce298098a0b95","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2019-08-14T23:05:08Z","title_canon_sha256":"f578a241af67bd9d4b9dbc836e0a734ed5f1cb082cd76951381787467bfa0d91"},"schema_version":"1.0","source":{"id":"1908.05370","kind":"arxiv","version":1}},"canonical_sha256":"f5aa0a59aa5c9b443b9995e28d5b81eb6bf7bd47d3c03db129cbaccf96082faa","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f5aa0a59aa5c9b443b9995e28d5b81eb6bf7bd47d3c03db129cbaccf96082faa","first_computed_at":"2026-07-04T23:56:50.896726Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-04T23:56:50.896726Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"KiV8bRdeeaKmgvLNjxGUot7/0B9fDbwJ0Yyo7O17s6GEWbPmeXEoH7rzFcdaayozld9uUvt9h1lG0ql9shTUAA==","signature_status":"signed_v1","signed_at":"2026-07-04T23:56:50.897096Z","signed_message":"canonical_sha256_bytes"},"source_id":"1908.05370","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:7ac55d59e29d3c65fd6ed8f5b2d88a7a45ed572f5a2ec11a1bed3092cb949f78","sha256:efd669d8e08c269114b2a9f2f8db2b18ec518f8dbbfa324f2766c0f15d7271aa"],"state_sha256":"170300287641ace8ab337298001429b0cca1b7944407bf5092d9d650af33debf"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/Wm0H1jAyUgjsdLMTXts5NDOUNKSU0lRb877Bz54mM4aEBfsys6aUiMXh7i/pLnn9NDYAHgd3jqT+zusx042DA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-16T05:47:30.815846Z","bundle_sha256":"03ef67ee201944ac9516cfb6dbb4276e9cd3eeab595a6f8d1530539e79d02bc8"}}