{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2012:6XFFBGHGPZ6TCBKARD7DRRZM46","short_pith_number":"pith:6XFFBGHG","canonical_record":{"source":{"id":"1211.2049","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-11-09T05:46:33Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"dc8f847dff435bc0c0ae530f8532e97d925e9ebee9d640a2f9726bf9b4e69000","abstract_canon_sha256":"e6b10efd94474cd3eb5892d67afaa64194c66ae1189b89d2f195a035554d3228"},"schema_version":"1.0"},"canonical_sha256":"f5ca5098e67e7d31054088fe38c72ce79384e0acf647a9cbce5496adeacf1d4d","source":{"kind":"arxiv","id":"1211.2049","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1211.2049","created_at":"2026-05-18T03:41:11Z"},{"alias_kind":"arxiv_version","alias_value":"1211.2049v1","created_at":"2026-05-18T03:41:11Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1211.2049","created_at":"2026-05-18T03:41:11Z"},{"alias_kind":"pith_short_12","alias_value":"6XFFBGHGPZ6T","created_at":"2026-05-18T12:26:56Z"},{"alias_kind":"pith_short_16","alias_value":"6XFFBGHGPZ6TCBKA","created_at":"2026-05-18T12:26:56Z"},{"alias_kind":"pith_short_8","alias_value":"6XFFBGHG","created_at":"2026-05-18T12:26:56Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2012:6XFFBGHGPZ6TCBKARD7DRRZM46","target":"record","payload":{"canonical_record":{"source":{"id":"1211.2049","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-11-09T05:46:33Z","cross_cats_sorted":["q-bio.QM"],"title_canon_sha256":"dc8f847dff435bc0c0ae530f8532e97d925e9ebee9d640a2f9726bf9b4e69000","abstract_canon_sha256":"e6b10efd94474cd3eb5892d67afaa64194c66ae1189b89d2f195a035554d3228"},"schema_version":"1.0"},"canonical_sha256":"f5ca5098e67e7d31054088fe38c72ce79384e0acf647a9cbce5496adeacf1d4d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:41:11.867467Z","signature_b64":"THpiR4PHUXrQq3/8XRKxauAklV+bGnf15PWsmQjxy7SNPTAHoVclR5B8D5nRb0xcLZJZqeq3tY02ZEFMrNoEDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"f5ca5098e67e7d31054088fe38c72ce79384e0acf647a9cbce5496adeacf1d4d","last_reissued_at":"2026-05-18T03:41:11.866991Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:41:11.866991Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1211.2049","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:41:11Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"fKl8/7poOZb6slZt/kxKUFbpE0ZlI/Ls73k2JemmnhO71ZYEd2RKFQ6Qm8zqFajE98aljPtm/e57hwPgQJKbDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T20:26:47.218869Z"},"content_sha256":"ecbefe715db2e9a0c25a9813c127d68e4e9658a72a18c0adf6440de0c030a39e","schema_version":"1.0","event_id":"sha256:ecbefe715db2e9a0c25a9813c127d68e4e9658a72a18c0adf6440de0c030a39e"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2012:6XFFBGHGPZ6TCBKARD7DRRZM46","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Improved haplotyping of rare variants using next-generation sequence data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.QM"],"primary_cat":"q-bio.GN","authors_text":"Carlos Bustamante, Fouad Zakharia","submitted_at":"2012-11-09T05:46:33Z","abstract_excerpt":"Accurate identification of haplotypes in sequenced human genomes can provide invaluable information about population demography and fine-scale correlations along the genome, thus empowering both population genomic and medical association studies. Yet phasing unrelated individuals remains a challenging problem. Incorporating available data from high throughput sequencing into traditional statistical phasing approaches is a promising avenue to alleviate these issues. We present a novel statistical method that expands on an existing graphical haplotype reconstruction method (shapeIT) to incorpora"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1211.2049","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:41:11Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"80jA0D+QeIVgYJKPpB3Bjgg/lGgUmh/RKsZFKviYf6YZazIPRNPyxpvhJJBMitO8bQxkwchAbophPU6Df8kTDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T20:26:47.219218Z"},"content_sha256":"82bfb4391c02e7945f24317c47646f65119583b8369871d9f1d79b8adfd7bc43","schema_version":"1.0","event_id":"sha256:82bfb4391c02e7945f24317c47646f65119583b8369871d9f1d79b8adfd7bc43"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/6XFFBGHGPZ6TCBKARD7DRRZM46/bundle.json","state_url":"https://pith.science/pith/6XFFBGHGPZ6TCBKARD7DRRZM46/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/6XFFBGHGPZ6TCBKARD7DRRZM46/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-04T20:26:47Z","links":{"resolver":"https://pith.science/pith/6XFFBGHGPZ6TCBKARD7DRRZM46","bundle":"https://pith.science/pith/6XFFBGHGPZ6TCBKARD7DRRZM46/bundle.json","state":"https://pith.science/pith/6XFFBGHGPZ6TCBKARD7DRRZM46/state.json","well_known_bundle":"https://pith.science/.well-known/pith/6XFFBGHGPZ6TCBKARD7DRRZM46/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:6XFFBGHGPZ6TCBKARD7DRRZM46","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e6b10efd94474cd3eb5892d67afaa64194c66ae1189b89d2f195a035554d3228","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-11-09T05:46:33Z","title_canon_sha256":"dc8f847dff435bc0c0ae530f8532e97d925e9ebee9d640a2f9726bf9b4e69000"},"schema_version":"1.0","source":{"id":"1211.2049","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1211.2049","created_at":"2026-05-18T03:41:11Z"},{"alias_kind":"arxiv_version","alias_value":"1211.2049v1","created_at":"2026-05-18T03:41:11Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1211.2049","created_at":"2026-05-18T03:41:11Z"},{"alias_kind":"pith_short_12","alias_value":"6XFFBGHGPZ6T","created_at":"2026-05-18T12:26:56Z"},{"alias_kind":"pith_short_16","alias_value":"6XFFBGHGPZ6TCBKA","created_at":"2026-05-18T12:26:56Z"},{"alias_kind":"pith_short_8","alias_value":"6XFFBGHG","created_at":"2026-05-18T12:26:56Z"}],"graph_snapshots":[{"event_id":"sha256:82bfb4391c02e7945f24317c47646f65119583b8369871d9f1d79b8adfd7bc43","target":"graph","created_at":"2026-05-18T03:41:11Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Accurate identification of haplotypes in sequenced human genomes can provide invaluable information about population demography and fine-scale correlations along the genome, thus empowering both population genomic and medical association studies. Yet phasing unrelated individuals remains a challenging problem. Incorporating available data from high throughput sequencing into traditional statistical phasing approaches is a promising avenue to alleviate these issues. We present a novel statistical method that expands on an existing graphical haplotype reconstruction method (shapeIT) to incorpora","authors_text":"Carlos Bustamante, Fouad Zakharia","cross_cats":["q-bio.QM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-11-09T05:46:33Z","title":"Improved haplotyping of rare variants using next-generation sequence data"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1211.2049","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ecbefe715db2e9a0c25a9813c127d68e4e9658a72a18c0adf6440de0c030a39e","target":"record","created_at":"2026-05-18T03:41:11Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e6b10efd94474cd3eb5892d67afaa64194c66ae1189b89d2f195a035554d3228","cross_cats_sorted":["q-bio.QM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-11-09T05:46:33Z","title_canon_sha256":"dc8f847dff435bc0c0ae530f8532e97d925e9ebee9d640a2f9726bf9b4e69000"},"schema_version":"1.0","source":{"id":"1211.2049","kind":"arxiv","version":1}},"canonical_sha256":"f5ca5098e67e7d31054088fe38c72ce79384e0acf647a9cbce5496adeacf1d4d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f5ca5098e67e7d31054088fe38c72ce79384e0acf647a9cbce5496adeacf1d4d","first_computed_at":"2026-05-18T03:41:11.866991Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:41:11.866991Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"THpiR4PHUXrQq3/8XRKxauAklV+bGnf15PWsmQjxy7SNPTAHoVclR5B8D5nRb0xcLZJZqeq3tY02ZEFMrNoEDA==","signature_status":"signed_v1","signed_at":"2026-05-18T03:41:11.867467Z","signed_message":"canonical_sha256_bytes"},"source_id":"1211.2049","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ecbefe715db2e9a0c25a9813c127d68e4e9658a72a18c0adf6440de0c030a39e","sha256:82bfb4391c02e7945f24317c47646f65119583b8369871d9f1d79b8adfd7bc43"],"state_sha256":"0c864c573458a2bd9b9d8e580ec38087c036f1a93c2606674cf32c1a245b827b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"E9ciZM3I8J1sYhNoIUPoS/wU6VUl639FDaTeyK6a+4pYUjNO4QA+nS0bGTeuYR3cTf8TwvIGwGTS0bgq31KoBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-04T20:26:47.221244Z","bundle_sha256":"11669a3426eedfce52b73c308f7a946381c4109c29f64e59e2716de7882eb080"}}