{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:6XYUEVDNOPMV2GQQOE5RTRVXWK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"8e6e4cc1bae845125804cec4712b94595a9cf5b2bb3f22d8fd90885ed5d429d4","cross_cats_sorted":["cs.AI","cs.LG","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ML","submitted_at":"2023-11-05T23:37:31Z","title_canon_sha256":"eff324355303913802768c845d77d19c335b7c4987db7e90a4b73e7858cf25e7"},"schema_version":"1.0","source":{"id":"2311.02794","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2311.02794","created_at":"2026-07-05T07:33:57Z"},{"alias_kind":"arxiv_version","alias_value":"2311.02794v2","created_at":"2026-07-05T07:33:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2311.02794","created_at":"2026-07-05T07:33:57Z"},{"alias_kind":"pith_short_12","alias_value":"6XYUEVDNOPMV","created_at":"2026-07-05T07:33:57Z"},{"alias_kind":"pith_short_16","alias_value":"6XYUEVDNOPMV2GQQ","created_at":"2026-07-05T07:33:57Z"},{"alias_kind":"pith_short_8","alias_value":"6XYUEVDN","created_at":"2026-07-05T07:33:57Z"}],"graph_snapshots":[{"event_id":"sha256:5efa6eb8e2508d9425452cef1a22655c12187a010a3bd97375e7c9f0761d2008","target":"graph","created_at":"2026-07-05T07:33:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2311.02794/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Generative models of observations under interventions have been a vibrant topic of interest across machine learning and the sciences in recent years. For example, in drug discovery, there is a need to model the effects of diverse interventions on cells in order to characterize unknown biological mechanisms of action. We propose the Sparse Additive Mechanism Shift Variational Autoencoder, SAMS-VAE, to combine compositionality, disentanglement, and interpretability for perturbation models. SAMS-VAE models the latent state of a perturbed sample as the sum of a local latent variable capturing samp","authors_text":"Michael Bereket, Theofanis Karaletsos","cross_cats":["cs.AI","cs.LG","q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ML","submitted_at":"2023-11-05T23:37:31Z","title":"Modelling Cellular Perturbations with the Sparse Additive Mechanism Shift Variational Autoencoder"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2311.02794","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9475ffd20b7e0a6c9caee19f7179e215ae2627e3ffd98da2f41fc1009b48c574","target":"record","created_at":"2026-07-05T07:33:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"8e6e4cc1bae845125804cec4712b94595a9cf5b2bb3f22d8fd90885ed5d429d4","cross_cats_sorted":["cs.AI","cs.LG","q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ML","submitted_at":"2023-11-05T23:37:31Z","title_canon_sha256":"eff324355303913802768c845d77d19c335b7c4987db7e90a4b73e7858cf25e7"},"schema_version":"1.0","source":{"id":"2311.02794","kind":"arxiv","version":2}},"canonical_sha256":"f5f142546d73d95d1a10713b19c6b7b281a6eac911a64bae1647b09bc1ffe90c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f5f142546d73d95d1a10713b19c6b7b281a6eac911a64bae1647b09bc1ffe90c","first_computed_at":"2026-07-05T07:33:57.790264Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T07:33:57.790264Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"wQ5SrLT6B+nvPz4Fvww3Xpp53wP/kw0Vb6ydZB5Pinm8BomQl5JJi87uk8jE4Us/WeTnYHqrL5ysti63H+m3BA==","signature_status":"signed_v1","signed_at":"2026-07-05T07:33:57.790714Z","signed_message":"canonical_sha256_bytes"},"source_id":"2311.02794","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9475ffd20b7e0a6c9caee19f7179e215ae2627e3ffd98da2f41fc1009b48c574","sha256:5efa6eb8e2508d9425452cef1a22655c12187a010a3bd97375e7c9f0761d2008"],"state_sha256":"0fd578e0856dea89b6847c456f7981643fb6110712330a82d8ec6843909e0c78"}