{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:6Z3EKCEE3EX46GTUCNLMQBUJ7F","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"42210a61c2ad6dd95a18d0054d7116c2cba5b6b9a624ea0a681ef12ddb82669c","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-11-04T01:59:30Z","title_canon_sha256":"4f33645b5f40a6d3c7799352438c4f70b7c437c7a85f01068f9915444afdb45b"},"schema_version":"1.0","source":{"id":"2411.01745","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2411.01745","created_at":"2026-07-05T09:30:35Z"},{"alias_kind":"arxiv_version","alias_value":"2411.01745v1","created_at":"2026-07-05T09:30:35Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2411.01745","created_at":"2026-07-05T09:30:35Z"},{"alias_kind":"pith_short_12","alias_value":"6Z3EKCEE3EX4","created_at":"2026-07-05T09:30:35Z"},{"alias_kind":"pith_short_16","alias_value":"6Z3EKCEE3EX46GTU","created_at":"2026-07-05T09:30:35Z"},{"alias_kind":"pith_short_8","alias_value":"6Z3EKCEE","created_at":"2026-07-05T09:30:35Z"}],"graph_snapshots":[{"event_id":"sha256:42127d6a3ea0b5ae00ab2cee9ef5f8e69bcdc6b9e0e793a4557f2e998e6722a1","target":"graph","created_at":"2026-07-05T09:30:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2411.01745/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Enzymes are biological catalysts that can accelerate chemical reactions compared to uncatalyzed reactions in aqueous environments. Their catalytic efficiency is quantified by the turnover number (kcat), a parameter in enzyme kinetics. Enhancing enzyme activity is important for optimizing slow chemical reactions, with far-reaching implications for both research and industrial applications. However, traditional wet-lab methods for measuring and optimizing enzyme activity are often resource-intensive and time-consuming. To address these limitations, we introduce kcatDiffuser, a novel regressor-gu","authors_text":"Kai Yi, Xiaozhu Yu, Yiqing Shen, Yu Guang Wang","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-11-04T01:59:30Z","title":"A Regressor-Guided Graph Diffusion Model for Predicting Enzyme Mutations to Enhance Turnover Number"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2411.01745","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c287fe19399548c871bb646be864530825f413a0e83937c644acb8916e8108d1","target":"record","created_at":"2026-07-05T09:30:35Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"42210a61c2ad6dd95a18d0054d7116c2cba5b6b9a624ea0a681ef12ddb82669c","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2024-11-04T01:59:30Z","title_canon_sha256":"4f33645b5f40a6d3c7799352438c4f70b7c437c7a85f01068f9915444afdb45b"},"schema_version":"1.0","source":{"id":"2411.01745","kind":"arxiv","version":1}},"canonical_sha256":"f676450884d92fcf1a741356c80689f962df32e5660ad3ef90ca00d8c00772d4","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"f676450884d92fcf1a741356c80689f962df32e5660ad3ef90ca00d8c00772d4","first_computed_at":"2026-07-05T09:30:35.664769Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T09:30:35.664769Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"ChPjRa2nRzjJ8sZ1Bzs1xFVA04OCDmhEFT5wNzLNTJbRMCQP9Eoj2WdZTWclgQYBRkz93Sf36sw0JlaHbzPbBQ==","signature_status":"signed_v1","signed_at":"2026-07-05T09:30:35.665237Z","signed_message":"canonical_sha256_bytes"},"source_id":"2411.01745","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c287fe19399548c871bb646be864530825f413a0e83937c644acb8916e8108d1","sha256:42127d6a3ea0b5ae00ab2cee9ef5f8e69bcdc6b9e0e793a4557f2e998e6722a1"],"state_sha256":"ada37c5aa346ba79c5711d7374bd25375b11989d4b0c40d8aab72eb63200e3db"}